Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4U67

Crystal structure of the large ribosomal subunit (50S) of Deinococcus radiodurans containing a three residue insertion in L22

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000049	molecular_function	tRNA binding
1	0003723	molecular_function	RNA binding
1	0003735	molecular_function	structural constituent of ribosome
1	0005737	cellular_component	cytoplasm
1	0005840	cellular_component	ribosome
1	0006412	biological_process	translation
1	0019843	molecular_function	rRNA binding
1	0022625	cellular_component	cytosolic large ribosomal subunit
1	1990904	cellular_component	ribonucleoprotein complex
2	0003723	molecular_function	RNA binding
2	0003735	molecular_function	structural constituent of ribosome
2	0005840	cellular_component	ribosome
2	0006412	biological_process	translation
2	0019843	molecular_function	rRNA binding
2	1990904	cellular_component	ribonucleoprotein complex
3	0003723	molecular_function	RNA binding
3	0003735	molecular_function	structural constituent of ribosome
3	0005840	cellular_component	ribosome
3	0006412	biological_process	translation
3	0019843	molecular_function	rRNA binding
3	0022625	cellular_component	cytosolic large ribosomal subunit
3	1990904	cellular_component	ribonucleoprotein complex
A	0002181	biological_process	cytoplasmic translation
A	0003723	molecular_function	RNA binding
A	0003735	molecular_function	structural constituent of ribosome
A	0005840	cellular_component	ribosome
A	0006412	biological_process	translation
A	0015934	cellular_component	large ribosomal subunit
A	0016740	molecular_function	transferase activity
A	0019843	molecular_function	rRNA binding
A	1990904	cellular_component	ribonucleoprotein complex
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005840	cellular_component	ribosome
B	0006412	biological_process	translation
B	0019843	molecular_function	rRNA binding
B	0022625	cellular_component	cytosolic large ribosomal subunit
B	1990904	cellular_component	ribonucleoprotein complex
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0005840	cellular_component	ribosome
C	0006412	biological_process	translation
C	0019843	molecular_function	rRNA binding
C	1990904	cellular_component	ribonucleoprotein complex
D	0000049	molecular_function	tRNA binding
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0019843	molecular_function	rRNA binding
D	0022625	cellular_component	cytosolic large ribosomal subunit
D	1990904	cellular_component	ribonucleoprotein complex
E	0002181	biological_process	cytoplasmic translation
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0019843	molecular_function	rRNA binding
E	0022625	cellular_component	cytosolic large ribosomal subunit
E	1990904	cellular_component	ribonucleoprotein complex
G	0003723	molecular_function	RNA binding
G	0003729	molecular_function	mRNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005840	cellular_component	ribosome
G	0006412	biological_process	translation
G	0017148	biological_process	negative regulation of translation
G	0019843	molecular_function	rRNA binding
G	0022625	cellular_component	cytosolic large ribosomal subunit
G	1990904	cellular_component	ribonucleoprotein complex
H	0003723	molecular_function	RNA binding
H	0003735	molecular_function	structural constituent of ribosome
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
H	0015934	cellular_component	large ribosomal subunit
H	0019843	molecular_function	rRNA binding
H	0022625	cellular_component	cytosolic large ribosomal subunit
H	0070180	molecular_function	large ribosomal subunit rRNA binding
H	1990904	cellular_component	ribonucleoprotein complex
I	0003723	molecular_function	RNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005840	cellular_component	ribosome
I	0006412	biological_process	translation
I	0015934	cellular_component	large ribosomal subunit
I	0019843	molecular_function	rRNA binding
I	0022625	cellular_component	cytosolic large ribosomal subunit
I	1990904	cellular_component	ribonucleoprotein complex
J	0000049	molecular_function	tRNA binding
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0005840	cellular_component	ribosome
J	0006412	biological_process	translation
J	0019843	molecular_function	rRNA binding
J	0022625	cellular_component	cytosolic large ribosomal subunit
J	1990904	cellular_component	ribonucleoprotein complex
K	0003723	molecular_function	RNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0019843	molecular_function	rRNA binding
K	0022625	cellular_component	cytosolic large ribosomal subunit
K	1990904	cellular_component	ribonucleoprotein complex
L	0003723	molecular_function	RNA binding
L	0003735	molecular_function	structural constituent of ribosome
L	0005737	cellular_component	cytoplasm
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0008097	molecular_function	5S rRNA binding
L	0019843	molecular_function	rRNA binding
L	0022625	cellular_component	cytosolic large ribosomal subunit
L	1990904	cellular_component	ribonucleoprotein complex
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0019843	molecular_function	rRNA binding
M	0022625	cellular_component	cytosolic large ribosomal subunit
M	1990904	cellular_component	ribonucleoprotein complex
N	0000027	biological_process	ribosomal large subunit assembly
N	0003723	molecular_function	RNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0019843	molecular_function	rRNA binding
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	1990904	cellular_component	ribonucleoprotein complex
O	0003723	molecular_function	RNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005737	cellular_component	cytoplasm
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0019843	molecular_function	rRNA binding
O	1990904	cellular_component	ribonucleoprotein complex
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	0015934	cellular_component	large ribosomal subunit
Q	0003723	molecular_function	RNA binding
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0019843	molecular_function	rRNA binding
Q	0022625	cellular_component	cytosolic large ribosomal subunit
Q	1990904	cellular_component	ribonucleoprotein complex
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0019843	molecular_function	rRNA binding
R	0022625	cellular_component	cytosolic large ribosomal subunit
R	1990904	cellular_component	ribonucleoprotein complex
S	0000049	molecular_function	tRNA binding
S	0003723	molecular_function	RNA binding
S	0003735	molecular_function	structural constituent of ribosome
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	0008097	molecular_function	5S rRNA binding
S	0019843	molecular_function	rRNA binding
S	0022625	cellular_component	cytosolic large ribosomal subunit
S	1990904	cellular_component	ribonucleoprotein complex
T	0000049	molecular_function	tRNA binding
T	0003723	molecular_function	RNA binding
T	0003735	molecular_function	structural constituent of ribosome
T	0005840	cellular_component	ribosome
T	0006412	biological_process	translation
T	0019843	molecular_function	rRNA binding
T	0022625	cellular_component	cytosolic large ribosomal subunit
T	1990904	cellular_component	ribonucleoprotein complex
U	0003735	molecular_function	structural constituent of ribosome
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
U	1990904	cellular_component	ribonucleoprotein complex
V	0003723	molecular_function	RNA binding
V	0003735	molecular_function	structural constituent of ribosome
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	0019843	molecular_function	rRNA binding
V	0022625	cellular_component	cytosolic large ribosomal subunit
V	1990904	cellular_component	ribonucleoprotein complex
W	0003723	molecular_function	RNA binding
W	0003735	molecular_function	structural constituent of ribosome
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
W	0015934	cellular_component	large ribosomal subunit
W	0019843	molecular_function	rRNA binding
W	0022625	cellular_component	cytosolic large ribosomal subunit
W	1990904	cellular_component	ribonucleoprotein complex
Z	0003723	molecular_function	RNA binding
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005840	cellular_component	ribosome
Z	0006412	biological_process	translation
Z	0008270	molecular_function	zinc ion binding
Z	0015934	cellular_component	large ribosomal subunit
Z	0019843	molecular_function	rRNA binding
Z	0046872	molecular_function	metal ion binding
Z	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue MG K 201

Chain	Residue
K	GLY4

site_id	AC2
Number of Residues	3
Details	binding site for residue MG X 2901

Chain	Residue
X	U800
X	A802
X	C803

site_id	AC3
Number of Residues	3
Details	binding site for residue MG X 2902

Chain	Residue
X	G2039
X	A2040
X	A2041

site_id	AC4
Number of Residues	1
Details	binding site for residue MG X 2903

Chain	Residue
X	A2684

site_id	AC5
Number of Residues	2
Details	binding site for residue MG X 2904

Chain	Residue
X	A1682
X	A1681

site_id	AC6
Number of Residues	2
Details	binding site for residue MG X 2905

Chain	Residue
X	G2661
X	A2701

site_id	AC7
Number of Residues	1
Details	binding site for residue MG X 2908

Chain	Residue
X	C1340

site_id	AC8
Number of Residues	3
Details	binding site for residue MG X 2909

Chain	Residue
X	U575
X	A576
X	U823

site_id	AC9
Number of Residues	2
Details	binding site for residue MG X 2910

Chain	Residue
X	C1765
X	A1777

site_id	AD1
Number of Residues	2
Details	binding site for residue MG X 2911

Chain	Residue
X	A2566
X	G2567

site_id	AD2
Number of Residues	4
Details	binding site for residue MG X 2912

Chain	Residue
X	U1280
X	A1281
X	C1989
X	A2031

site_id	AD3
Number of Residues	1
Details	binding site for residue MG X 2913

Chain	Residue
X	A1980

site_id	AD4
Number of Residues	3
Details	binding site for residue MG X 2914

Chain	Residue
X	C1310
X	A2690
X	A2692

site_id	AD5
Number of Residues	2
Details	binding site for residue MG X 2915

Chain	Residue
X	A1278
X	U2594

site_id	AD6
Number of Residues	1
Details	binding site for residue MG X 2917

Chain	Residue
X	A984

site_id	AD7
Number of Residues	1
Details	binding site for residue MG X 2918

Chain	Residue
X	C2008

site_id	AD8
Number of Residues	2
Details	binding site for residue MG X 2919

Chain	Residue
X	C169
X	U2222

site_id	AD9
Number of Residues	2
Details	binding site for residue MG X 2920

Chain	Residue
X	G2044
X	G2481

site_id	AE1
Number of Residues	1
Details	binding site for residue MG X 2921

Chain	Residue
X	A815

site_id	AE2
Number of Residues	2
Details	binding site for residue MG X 2922

Chain	Residue
X	A764
X	A1630

site_id	AE3
Number of Residues	3
Details	binding site for residue MG X 2923

Chain	Residue
X	A1771
X	C1773
X	A1774

site_id	AE4
Number of Residues	1
Details	binding site for residue MG X 2924

Chain	Residue
X	C226

site_id	AE5
Number of Residues	2
Details	binding site for residue MG X 2925

Chain	Residue
X	C1687
X	U1688

site_id	AE6
Number of Residues	2
Details	binding site for residue MG X 2926

Chain	Residue
X	G754
X	A1776

site_id	AE7
Number of Residues	4
Details	binding site for residue MG X 2927

Chain	Residue
X	G676
X	G951
X	G1205
X	G1206

site_id	AE8
Number of Residues	2
Details	binding site for residue MG X 2928

Chain	Residue
X	U585
X	A2482

site_id	AE9
Number of Residues	5
Details	binding site for residue MG X 2929

Chain	Residue
X	A743
X	C744
X	A774
X	U775
X	G776

site_id	AF1
Number of Residues	3
Details	binding site for residue MG X 2930

Chain	Residue
X	G2036
X	G2555
X	A2556

site_id	AF2
Number of Residues	3
Details	binding site for residue MG X 2931

Chain	Residue
X	A2690
X	A2692
X	G2694

site_id	AF3
Number of Residues	1
Details	binding site for residue MG X 2932

Chain	Residue
X	C1348

site_id	AF4
Number of Residues	3
Details	binding site for residue MG X 2933

Chain	Residue
X	C959
X	U973
X	U974

site_id	AF5
Number of Residues	2
Details	binding site for residue MG X 2934

Chain	Residue
X	A797
X	G2567

site_id	AF6
Number of Residues	3
Details	binding site for residue MG X 2935

Chain	Residue
X	A2409
X	U2410
X	A2411

site_id	AF7
Number of Residues	4
Details	binding site for residue MG X 2936

Chain	Residue
X	C2486
X	C2552
X	G2553
X	C2554

site_id	AF8
Number of Residues	2
Details	binding site for residue MG X 2937

Chain	Residue
X	A14
X	G15

site_id	AF9
Number of Residues	3
Details	binding site for residue MG X 2938

Chain	Residue
X	C1311
X	G1312
X	U1656

site_id	AG1
Number of Residues	4
Details	binding site for residue MG X 2939

Chain	Residue
X	A1686
X	C1687
X	U1688
X	G2529

site_id	AG2
Number of Residues	2
Details	binding site for residue MG X 2940

Chain	Residue
X	U2057
X	G2218

site_id	AG3
Number of Residues	1
Details	binding site for residue MG X 2941

Chain	Residue
X	G2361

site_id	AG4
Number of Residues	3
Details	binding site for residue MG X 2942

Chain	Residue
P	ARG114
X	U760
X	G761

site_id	AG5
Number of Residues	3
Details	binding site for residue MG X 2943

Chain	Residue
X	U753
X	A1774
X	A1775

site_id	AG6
Number of Residues	1
Details	binding site for residue MG X 2944

Chain	Residue
X	G844

site_id	AG7
Number of Residues	4
Details	binding site for residue MG X 2945

Chain	Residue
X	C175
X	G171
X	A172
X	A174

site_id	AG8
Number of Residues	1
Details	binding site for residue MG X 2946

Chain	Residue
X	U1656

site_id	AG9
Number of Residues	2
Details	binding site for residue MG X 2947

Chain	Residue
X	U823
X	G1266

site_id	AH1
Number of Residues	3
Details	binding site for residue MG X 2948

Chain	Residue
X	C520
X	U521
X	G522

site_id	AH2
Number of Residues	3
Details	binding site for residue MG X 2949

Chain	Residue
X	C750
X	U1637
X	G1638

Functional Information from PROSITE/UniProt

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVVrtshaikra.DGstirFdrNaaVI

Chain	Residue	Details
H	ALA72-ILE98

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAIVRLAegqsieaL

Chain	Residue	Details
Q	LYS76-LEU91

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PhqRGSAmNPvD

Chain	Residue	Details
A	PRO219-ASP230

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FaegekiDatGtSkGKGtqGvmkR

Chain	Residue	Details
B	PHE96-ARG119

site_id	PS00475
Number of Residues	31
Details	RIBOSOMAL_L15 Ribosomal protein L15 signature. KLLAsGeIsra..VtVhvdaASaaAikaVeaaG

Chain	Residue	Details
I	LYS107-GLY137

site_id	PS00579
Number of Residues	15
Details	RIBOSOMAL_L29 Ribosomal protein L29 signature. QPHRVRqLRREVAQL

Chain	Residue	Details
V	GLN39-LEU53

site_id	PS00582
Number of Residues	20
Details	RIBOSOMAL_L33 Ribosomal protein L33 signature. YtTtKNrrntQakLElkKYD

Chain	Residue	Details
1	TYR22-ASP41

site_id	PS00586
Number of Residues	12
Details	RIBOSOMAL_L16_1 Ribosomal protein L16 signature 1. RRgGKIYIRIFP

Chain	Residue	Details
J	ARG60-PRO71

site_id	PS00701
Number of Residues	12
Details	RIBOSOMAL_L16_2 Ribosomal protein L16 signature 2. RMGkGKGaveyW

Chain	Residue	Details
J	ARG83-TRP94

site_id	PS00783
Number of Residues	23
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. VFGMLPkgrq.GRamhtrLkVYaG

Chain	Residue	Details
G	VAL131-GLY153

site_id	PS00784
Number of Residues	20
Details	RIBOSOMAL_L34 Ribosomal protein L34 signature. KRTYQpnnrkRakth.GFraR

Chain	Residue	Details
2	LYS2-ARG21

site_id	PS00831
Number of Residues	15
Details	RIBOSOMAL_L27 Ribosomal protein L27 signature. GnILvRQRGtkfkaG

Chain	Residue	Details
T	GLY34-GLY48

site_id	PS00936
Number of Residues	27
Details	RIBOSOMAL_L35 Ribosomal protein L35 signature. KTHkMAkRRIkitgtgkvmafksgk.RH

Chain	Residue	Details
3	LYS5-HIS31

site_id	PS00937
Number of Residues	17
Details	RIBOSOMAL_L20 Ribosomal protein L20 signature. KrdfRrLWIQRINagaR

Chain	Residue	Details
N	LYS54-ARG70

site_id	PS01015
Number of Residues	16
Details	RIBOSOMAL_L19 Ribosomal protein L19 signature. IvErGKVR.RAKLYYLR

Chain	Residue	Details
M	ILE93-ARG108

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. GDtViVLsGkhKGqt.GkV

Chain	Residue	Details
R	GLY19-VAL36

site_id	PS01167
Number of Residues	23
Details	RIBOSOMAL_L17 Ribosomal protein L17 signature. IqTTltKaKelrpfvEqLITtAK

Chain	Residue	Details
K	ILE34-LYS56

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	23
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	103
Details	Region: {"description":"N-terminal domain"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)