4U3F

Cytochrome bc1 complex from chicken with designed inhibitor bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005743	cellular_component	mitochondrial inner membrane
A	0016020	cellular_component	membrane
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
B	0005743	cellular_component	mitochondrial inner membrane
B	0045275	cellular_component	respiratory chain complex III
B	0046872	molecular_function	metal ion binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0006979	biological_process	response to oxidative stress
C	0008121	molecular_function	quinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0045275	cellular_component	respiratory chain complex III
C	0046872	molecular_function	metal ion binding
C	1902600	biological_process	proton transmembrane transport
D	0005743	cellular_component	mitochondrial inner membrane
D	0009055	molecular_function	electron transfer activity
D	0016020	cellular_component	membrane
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
E	0008121	molecular_function	quinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005743	cellular_component	mitochondrial inner membrane
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0016020	cellular_component	membrane
F	0045275	cellular_component	respiratory chain complex III
G	0005743	cellular_component	mitochondrial inner membrane
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0016020	cellular_component	membrane
G	0045275	cellular_component	respiratory chain complex III
H	0005743	cellular_component	mitochondrial inner membrane
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0016020	cellular_component	membrane
H	0098803	cellular_component	respiratory chain complex
I	0008121	molecular_function	quinol-cytochrome-c reductase activity
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0009060	biological_process	aerobic respiration
J	0016020	cellular_component	membrane
J	0045275	cellular_component	respiratory chain complex III
N	0005743	cellular_component	mitochondrial inner membrane
N	0016020	cellular_component	membrane
N	0032991	cellular_component	protein-containing complex
N	0046872	molecular_function	metal ion binding
O	0005743	cellular_component	mitochondrial inner membrane
O	0045275	cellular_component	respiratory chain complex III
O	0046872	molecular_function	metal ion binding
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
P	0006979	biological_process	response to oxidative stress
P	0008121	molecular_function	quinol-cytochrome-c reductase activity
P	0009055	molecular_function	electron transfer activity
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0020037	molecular_function	heme binding
P	0022904	biological_process	respiratory electron transport chain
P	0045275	cellular_component	respiratory chain complex III
P	0046872	molecular_function	metal ion binding
P	1902600	biological_process	proton transmembrane transport
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0009055	molecular_function	electron transfer activity
Q	0016020	cellular_component	membrane
Q	0020037	molecular_function	heme binding
Q	0046872	molecular_function	metal ion binding
R	0008121	molecular_function	quinol-cytochrome-c reductase activity
R	0016020	cellular_component	membrane
R	0051537	molecular_function	2 iron, 2 sulfur cluster binding
S	0005743	cellular_component	mitochondrial inner membrane
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0016020	cellular_component	membrane
S	0045275	cellular_component	respiratory chain complex III
T	0005743	cellular_component	mitochondrial inner membrane
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0016020	cellular_component	membrane
T	0045275	cellular_component	respiratory chain complex III
U	0005743	cellular_component	mitochondrial inner membrane
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0016020	cellular_component	membrane
U	0098803	cellular_component	respiratory chain complex
V	0008121	molecular_function	quinol-cytochrome-c reductase activity
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
W	0009060	biological_process	aerobic respiration
W	0016020	cellular_component	membrane
W	0045275	cellular_component	respiratory chain complex III

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	322
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"20025846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21575592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22690928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9565029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3L70","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00968","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20025846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21575592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22690928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9565029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BCC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BCC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BCC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L70","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L75","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TGU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20025846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21575592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22690928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9565029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BCC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BCC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BCC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L70","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L75","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TGU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20025846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21575592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22690928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9565029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BCC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BCC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L70","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L71","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L75","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TGU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21575592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22690928","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9565029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BCC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CWB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L72","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	54
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"UniProtKB","id":"P13272","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	66
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"9565029","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	266
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"UniProtKB","id":"P13272","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	170
Details	Domain: {"description":"Rieske","evidences":[{"source":"PROSITE-ProRule","id":"PRU00628","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9565029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3H1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9565029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3H1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H1I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---