4U2K
X-ray structure uridine phosphorylase from Vibrio cholerae in complex with anticancer compound at 2.13 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0044206 | biological_process | UMP salvage |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0044206 | biological_process | UMP salvage |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0009166 | biological_process | nucleotide catabolic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0044206 | biological_process | UMP salvage |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0009166 | biological_process | nucleotide catabolic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0044206 | biological_process | UMP salvage |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009164 | biological_process | nucleoside catabolic process |
| E | 0009166 | biological_process | nucleotide catabolic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0044206 | biological_process | UMP salvage |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009164 | biological_process | nucleoside catabolic process |
| F | 0009166 | biological_process | nucleotide catabolic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0044206 | biological_process | UMP salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 301 |
| Chain | Residue |
| A | PHE161 |
| A | GLN165 |
| A | HOH403 |
| A | HOH407 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | ARG178 |
| A | HOH504 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 301 |
| Chain | Residue |
| C | HOH424 |
| A | PHE171 |
| A | THR172 |
| B | SER208 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue 4WR B 302 |
| Chain | Residue |
| A | HIS7 |
| B | THR94 |
| B | GLY95 |
| B | PHE161 |
| B | GLN165 |
| B | ARG167 |
| B | PHE194 |
| B | GLU195 |
| B | MET196 |
| B | ILE220 |
| B | HOH401 |
| B | HOH411 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 301 |
| Chain | Residue |
| C | ILE68 |
| C | PHE161 |
| C | MET196 |
| D | HIS7 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 302 |
| Chain | Residue |
| C | ARG167 |
| C | ARG222 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 301 |
| Chain | Residue |
| C | ARG47 |
| D | GLY25 |
| D | ASP26 |
| D | GLY67 |
| D | ARG90 |
| D | GLU197 |
| D | M5F303 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue PEG D 302 |
| Chain | Residue |
| D | PRO131 |
| D | ASP132 |
| D | GLY209 |
| D | LEU210 |
| D | LYS211 |
| D | ALA212 |
| D | HOH415 |
| D | HOH422 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | binding site for residue M5F D 303 |
| Chain | Residue |
| C | HIS7 |
| D | THR93 |
| D | THR94 |
| D | GLY95 |
| D | PHE161 |
| D | GLN165 |
| D | ARG167 |
| D | PHE194 |
| D | GLU195 |
| D | MET196 |
| D | ILE219 |
| D | ILE220 |
| D | GOL301 |
| D | 4WR304 |
| D | HOH405 |
| D | HOH409 |
| D | HOH457 |
| site_id | AD1 |
| Number of Residues | 14 |
| Details | binding site for residue 4WR D 304 |
| Chain | Residue |
| C | HIS7 |
| D | THR93 |
| D | THR94 |
| D | GLY95 |
| D | GLN165 |
| D | ARG167 |
| D | PHE194 |
| D | GLU195 |
| D | MET196 |
| D | ILE219 |
| D | M5F303 |
| D | HOH405 |
| D | HOH409 |
| D | HOH457 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue GOL E 301 |
| Chain | Residue |
| A | ASN39 |
| E | HOH415 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO E 302 |
| Chain | Residue |
| E | PRO24 |
| E | GLY25 |
| E | ASP26 |
| E | ARG29 |
| E | VAL91 |
| E | GLY92 |
| F | ARG47 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO E 303 |
| Chain | Residue |
| E | ARG90 |
| E | VAL91 |
| E | GLY92 |
| E | GLU195 |
| E | VAL215 |
| E | ALA216 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue TRS F 301 |
| Chain | Residue |
| F | PHE6 |
| F | ARG47 |
| F | HOH463 |
| site_id | AD6 |
| Number of Residues | 13 |
| Details | binding site for residue M5F F 302 |
| Chain | Residue |
| F | ILE219 |
| F | ILE220 |
| F | HOH414 |
| F | HOH415 |
| F | HOH433 |
| F | HOH441 |
| E | HIS7 |
| F | THR93 |
| F | PHE161 |
| F | GLN165 |
| F | ARG167 |
| F | GLU195 |
| F | MET196 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER65-LEU80 |
