Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4U2K

X-ray structure uridine phosphorylase from Vibrio cholerae in complex with anticancer compound at 2.13 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0044206	biological_process	UMP salvage
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005737	cellular_component	cytoplasm
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0044206	biological_process	UMP salvage
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005737	cellular_component	cytoplasm
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0044206	biological_process	UMP salvage
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005737	cellular_component	cytoplasm
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0044206	biological_process	UMP salvage
D	0046872	molecular_function	metal ion binding
E	0003824	molecular_function	catalytic activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005737	cellular_component	cytoplasm
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0009166	biological_process	nucleotide catabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0044206	biological_process	UMP salvage
E	0046872	molecular_function	metal ion binding
F	0003824	molecular_function	catalytic activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005737	cellular_component	cytoplasm
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0009166	biological_process	nucleotide catabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0044206	biological_process	UMP salvage
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 301

Chain	Residue
A	PHE161
A	GLN165
A	HOH403
A	HOH407

site_id	AC2
Number of Residues	2
Details	binding site for residue EDO A 302

Chain	Residue
A	ARG178
A	HOH504

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO B 301

Chain	Residue
C	HOH424
A	PHE171
A	THR172
B	SER208

site_id	AC4
Number of Residues	12
Details	binding site for residue 4WR B 302

Chain	Residue
A	HIS7
B	THR94
B	GLY95
B	PHE161
B	GLN165
B	ARG167
B	PHE194
B	GLU195
B	MET196
B	ILE220
B	HOH401
B	HOH411

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO C 301

Chain	Residue
C	ILE68
C	PHE161
C	MET196
D	HIS7

site_id	AC6
Number of Residues	2
Details	binding site for residue EDO C 302

Chain	Residue
C	ARG167
C	ARG222

site_id	AC7
Number of Residues	7
Details	binding site for residue GOL D 301

Chain	Residue
C	ARG47
D	GLY25
D	ASP26
D	GLY67
D	ARG90
D	GLU197
D	M5F303

site_id	AC8
Number of Residues	8
Details	binding site for residue PEG D 302

Chain	Residue
D	PRO131
D	ASP132
D	GLY209
D	LEU210
D	LYS211
D	ALA212
D	HOH415
D	HOH422

site_id	AC9
Number of Residues	17
Details	binding site for residue M5F D 303

Chain	Residue
C	HIS7
D	THR93
D	THR94
D	GLY95
D	PHE161
D	GLN165
D	ARG167
D	PHE194
D	GLU195
D	MET196
D	ILE219
D	ILE220
D	GOL301
D	4WR304
D	HOH405
D	HOH409
D	HOH457

site_id	AD1
Number of Residues	14
Details	binding site for residue 4WR D 304

Chain	Residue
C	HIS7
D	THR93
D	THR94
D	GLY95
D	GLN165
D	ARG167
D	PHE194
D	GLU195
D	MET196
D	ILE219
D	M5F303
D	HOH405
D	HOH409
D	HOH457

site_id	AD2
Number of Residues	2
Details	binding site for residue GOL E 301

Chain	Residue
A	ASN39
E	HOH415

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO E 302

Chain	Residue
E	PRO24
E	GLY25
E	ASP26
E	ARG29
E	VAL91
E	GLY92
F	ARG47

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO E 303

Chain	Residue
E	ARG90
E	VAL91
E	GLY92
E	GLU195
E	VAL215
E	ALA216

site_id	AD5
Number of Residues	3
Details	binding site for residue TRS F 301

Chain	Residue
F	PHE6
F	ARG47
F	HOH463

site_id	AD6
Number of Residues	13
Details	binding site for residue M5F F 302

Chain	Residue
F	ILE219
F	ILE220
F	HOH414
F	HOH415
F	HOH433
F	HOH441
E	HIS7
F	THR93
F	PHE161
F	GLN165
F	ARG167
F	GLU195
F	MET196

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL

Chain	Residue	Details
A	SER65-LEU80

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)