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4U1W

Full length GluA2-kainate-(R,R)-2b complex crystal form A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000149molecular_functionSNARE binding
A0001540molecular_functionamyloid-beta binding
A0001919biological_processregulation of receptor recycling
A0004970molecular_functionglutamate-gated receptor activity
A0004971molecular_functionAMPA glutamate receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005234molecular_functionextracellularly glutamate-gated ion channel activity
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007268biological_processchemical synaptic transmission
A0008021cellular_componentsynaptic vesicle
A0008092molecular_functioncytoskeletal protein binding
A0008328cellular_componentionotropic glutamate receptor complex
A0009986cellular_componentcell surface
A0010226biological_processresponse to lithium ion
A0014069cellular_componentpostsynaptic density
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015277molecular_functionkainate selective glutamate receptor activity
A0016020cellular_componentmembrane
A0019865molecular_functionimmunoglobulin binding
A0019901molecular_functionprotein kinase binding
A0021987biological_processcerebral cortex development
A0022890molecular_functioninorganic cation transmembrane transporter activity
A0030165molecular_functionPDZ domain binding
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0030672cellular_componentsynaptic vesicle membrane
A0031623biological_processreceptor internalization
A0032279cellular_componentasymmetric synapse
A0032281cellular_componentAMPA glutamate receptor complex
A0032590cellular_componentdendrite membrane
A0032839cellular_componentdendrite cytoplasm
A0032991cellular_componentprotein-containing complex
A0034220biological_processmonoatomic ion transmembrane transport
A0035235biological_processionotropic glutamate receptor signaling pathway
A0035249biological_processsynaptic transmission, glutamatergic
A0035254molecular_functionglutamate receptor binding
A0035255molecular_functionionotropic glutamate receptor binding
A0036477cellular_componentsomatodendritic compartment
A0038023molecular_functionsignaling receptor activity
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043195cellular_componentterminal bouton
A0043197cellular_componentdendritic spine
A0043198cellular_componentdendritic shaft
A0043204cellular_componentperikaryon
A0043226cellular_componentorganelle
A0044326cellular_componentdendritic spine neck
A0044327cellular_componentdendritic spine head
A0044877molecular_functionprotein-containing complex binding
A0045184biological_processestablishment of protein localization
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0048787cellular_componentpresynaptic active zone membrane
A0050804biological_processmodulation of chemical synaptic transmission
A0050806biological_processpositive regulation of synaptic transmission
A0051262biological_processprotein tetramerization
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0060078biological_processregulation of postsynaptic membrane potential
A0060079biological_processexcitatory postsynaptic potential
A0060992biological_processresponse to fungicide
A0097060cellular_componentsynaptic membrane
A0097110molecular_functionscaffold protein binding
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098793cellular_componentpresynapse
A0098839cellular_componentpostsynaptic density membrane
A0098978cellular_componentglutamatergic synapse
A0099505biological_processregulation of presynaptic membrane potential
A0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A0099544cellular_componentperisynaptic space
A0106033cellular_componentspine synapse
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A1905430biological_processcellular response to glycine
A1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
B0000149molecular_functionSNARE binding
B0001540molecular_functionamyloid-beta binding
B0001919biological_processregulation of receptor recycling
B0004970molecular_functionglutamate-gated receptor activity
B0004971molecular_functionAMPA glutamate receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005234molecular_functionextracellularly glutamate-gated ion channel activity
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0007268biological_processchemical synaptic transmission
B0008021cellular_componentsynaptic vesicle
B0008092molecular_functioncytoskeletal protein binding
B0008328cellular_componentionotropic glutamate receptor complex
B0009986cellular_componentcell surface
B0010226biological_processresponse to lithium ion
B0014069cellular_componentpostsynaptic density
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0015277molecular_functionkainate selective glutamate receptor activity
B0016020cellular_componentmembrane
B0019865molecular_functionimmunoglobulin binding
B0019901molecular_functionprotein kinase binding
B0021987biological_processcerebral cortex development
B0022890molecular_functioninorganic cation transmembrane transporter activity
B0030165molecular_functionPDZ domain binding
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030426cellular_componentgrowth cone
B0030672cellular_componentsynaptic vesicle membrane
B0031623biological_processreceptor internalization
B0032279cellular_componentasymmetric synapse
B0032281cellular_componentAMPA glutamate receptor complex
B0032590cellular_componentdendrite membrane
B0032839cellular_componentdendrite cytoplasm
B0032991cellular_componentprotein-containing complex
B0034220biological_processmonoatomic ion transmembrane transport
B0035235biological_processionotropic glutamate receptor signaling pathway
B0035249biological_processsynaptic transmission, glutamatergic
B0035254molecular_functionglutamate receptor binding
B0035255molecular_functionionotropic glutamate receptor binding
B0036477cellular_componentsomatodendritic compartment
B0038023molecular_functionsignaling receptor activity
B0042734cellular_componentpresynaptic membrane
B0042802molecular_functionidentical protein binding
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043195cellular_componentterminal bouton
B0043197cellular_componentdendritic spine
B0043198cellular_componentdendritic shaft
B0043204cellular_componentperikaryon
B0043226cellular_componentorganelle
B0044326cellular_componentdendritic spine neck
B0044327cellular_componentdendritic spine head
B0044877molecular_functionprotein-containing complex binding
B0045184biological_processestablishment of protein localization
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0048787cellular_componentpresynaptic active zone membrane
B0050804biological_processmodulation of chemical synaptic transmission
B0050806biological_processpositive regulation of synaptic transmission
B0051262biological_processprotein tetramerization
B0051966biological_processregulation of synaptic transmission, glutamatergic
B0060078biological_processregulation of postsynaptic membrane potential
B0060079biological_processexcitatory postsynaptic potential
B0060992biological_processresponse to fungicide
B0097060cellular_componentsynaptic membrane
B0097110molecular_functionscaffold protein binding
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098793cellular_componentpresynapse
B0098839cellular_componentpostsynaptic density membrane
B0098978cellular_componentglutamatergic synapse
B0099505biological_processregulation of presynaptic membrane potential
B0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B0099544cellular_componentperisynaptic space
B0106033cellular_componentspine synapse
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B1905430biological_processcellular response to glycine
B1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
C0000149molecular_functionSNARE binding
C0001540molecular_functionamyloid-beta binding
C0001919biological_processregulation of receptor recycling
C0004970molecular_functionglutamate-gated receptor activity
C0004971molecular_functionAMPA glutamate receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005234molecular_functionextracellularly glutamate-gated ion channel activity
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007268biological_processchemical synaptic transmission
C0008021cellular_componentsynaptic vesicle
C0008092molecular_functioncytoskeletal protein binding
C0008328cellular_componentionotropic glutamate receptor complex
C0009986cellular_componentcell surface
C0010226biological_processresponse to lithium ion
C0014069cellular_componentpostsynaptic density
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0015277molecular_functionkainate selective glutamate receptor activity
C0016020cellular_componentmembrane
C0019865molecular_functionimmunoglobulin binding
C0019901molecular_functionprotein kinase binding
C0021987biological_processcerebral cortex development
C0022890molecular_functioninorganic cation transmembrane transporter activity
C0030165molecular_functionPDZ domain binding
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030426cellular_componentgrowth cone
C0030672cellular_componentsynaptic vesicle membrane
C0031623biological_processreceptor internalization
C0032279cellular_componentasymmetric synapse
C0032281cellular_componentAMPA glutamate receptor complex
C0032590cellular_componentdendrite membrane
C0032839cellular_componentdendrite cytoplasm
C0032991cellular_componentprotein-containing complex
C0034220biological_processmonoatomic ion transmembrane transport
C0035235biological_processionotropic glutamate receptor signaling pathway
C0035249biological_processsynaptic transmission, glutamatergic
C0035254molecular_functionglutamate receptor binding
C0035255molecular_functionionotropic glutamate receptor binding
C0036477cellular_componentsomatodendritic compartment
C0038023molecular_functionsignaling receptor activity
C0042734cellular_componentpresynaptic membrane
C0042802molecular_functionidentical protein binding
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043195cellular_componentterminal bouton
C0043197cellular_componentdendritic spine
C0043198cellular_componentdendritic shaft
C0043204cellular_componentperikaryon
C0043226cellular_componentorganelle
C0044326cellular_componentdendritic spine neck
C0044327cellular_componentdendritic spine head
C0044877molecular_functionprotein-containing complex binding
C0045184biological_processestablishment of protein localization
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0048787cellular_componentpresynaptic active zone membrane
C0050804biological_processmodulation of chemical synaptic transmission
C0050806biological_processpositive regulation of synaptic transmission
C0051262biological_processprotein tetramerization
C0051966biological_processregulation of synaptic transmission, glutamatergic
C0060078biological_processregulation of postsynaptic membrane potential
C0060079biological_processexcitatory postsynaptic potential
C0060992biological_processresponse to fungicide
C0097060cellular_componentsynaptic membrane
C0097110molecular_functionscaffold protein binding
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098793cellular_componentpresynapse
C0098839cellular_componentpostsynaptic density membrane
C0098978cellular_componentglutamatergic synapse
C0099505biological_processregulation of presynaptic membrane potential
C0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C0099544cellular_componentperisynaptic space
C0106033cellular_componentspine synapse
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C1905430biological_processcellular response to glycine
C1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
D0000149molecular_functionSNARE binding
D0001540molecular_functionamyloid-beta binding
D0001919biological_processregulation of receptor recycling
D0004970molecular_functionglutamate-gated receptor activity
D0004971molecular_functionAMPA glutamate receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005234molecular_functionextracellularly glutamate-gated ion channel activity
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0007268biological_processchemical synaptic transmission
D0008021cellular_componentsynaptic vesicle
D0008092molecular_functioncytoskeletal protein binding
D0008328cellular_componentionotropic glutamate receptor complex
D0009986cellular_componentcell surface
D0010226biological_processresponse to lithium ion
D0014069cellular_componentpostsynaptic density
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0015277molecular_functionkainate selective glutamate receptor activity
D0016020cellular_componentmembrane
D0019865molecular_functionimmunoglobulin binding
D0019901molecular_functionprotein kinase binding
D0021987biological_processcerebral cortex development
D0022890molecular_functioninorganic cation transmembrane transporter activity
D0030165molecular_functionPDZ domain binding
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030426cellular_componentgrowth cone
D0030672cellular_componentsynaptic vesicle membrane
D0031623biological_processreceptor internalization
D0032279cellular_componentasymmetric synapse
D0032281cellular_componentAMPA glutamate receptor complex
D0032590cellular_componentdendrite membrane
D0032839cellular_componentdendrite cytoplasm
D0032991cellular_componentprotein-containing complex
D0034220biological_processmonoatomic ion transmembrane transport
D0035235biological_processionotropic glutamate receptor signaling pathway
D0035249biological_processsynaptic transmission, glutamatergic
D0035254molecular_functionglutamate receptor binding
D0035255molecular_functionionotropic glutamate receptor binding
D0036477cellular_componentsomatodendritic compartment
D0038023molecular_functionsignaling receptor activity
D0042734cellular_componentpresynaptic membrane
D0042802molecular_functionidentical protein binding
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043195cellular_componentterminal bouton
D0043197cellular_componentdendritic spine
D0043198cellular_componentdendritic shaft
D0043204cellular_componentperikaryon
D0043226cellular_componentorganelle
D0044326cellular_componentdendritic spine neck
D0044327cellular_componentdendritic spine head
D0044877molecular_functionprotein-containing complex binding
D0045184biological_processestablishment of protein localization
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0048787cellular_componentpresynaptic active zone membrane
D0050804biological_processmodulation of chemical synaptic transmission
D0050806biological_processpositive regulation of synaptic transmission
D0051262biological_processprotein tetramerization
D0051966biological_processregulation of synaptic transmission, glutamatergic
D0060078biological_processregulation of postsynaptic membrane potential
D0060079biological_processexcitatory postsynaptic potential
D0060992biological_processresponse to fungicide
D0097060cellular_componentsynaptic membrane
D0097110molecular_functionscaffold protein binding
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098793cellular_componentpresynapse
D0098839cellular_componentpostsynaptic density membrane
D0098978cellular_componentglutamatergic synapse
D0099505biological_processregulation of presynaptic membrane potential
D0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D0099544cellular_componentperisynaptic space
D0106033cellular_componentspine synapse
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D1905430biological_processcellular response to glycine
D1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues160
DetailsTRANSMEM: Helical
ChainResidueDetails
AMET527-SER547
AILE600-LEU620
BMET527-SER547
BILE600-LEU620
CMET527-SER547
CILE600-LEU620
DMET527-SER547
DILE600-LEU620

site_idSWS_FT_FI2
Number of Residues124
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
APRO548-PHE574
AARG594-ARG599
BPRO548-PHE574
BARG594-ARG599
CPRO548-PHE574
CARG594-ARG599
DPRO548-PHE574
DARG594-ARG599

site_idSWS_FT_FI3
Number of Residues60
DetailsINTRAMEM: Helical; Pore-forming
ChainResidueDetails
AASN575-ASP590
BASN575-ASP590
CASN575-ASP590
DASN575-ASP590

site_idSWS_FT_FI4
Number of Residues8
DetailsINTRAMEM:
ChainResidueDetails
AILE591-PRO593
BILE591-PRO593
CILE591-PRO593
DILE591-PRO593

site_idSWS_FT_FI5
Number of Residues696
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
AALA621-VAL795
BALA621-VAL795
CALA621-VAL795
DALA621-VAL795

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Name=M4
ChainResidueDetails
APHE796-TYR816
BPHE796-TYR816
CPHE796-TYR816
DPHE796-TYR816

site_idSWS_FT_FI7
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:16483599
ChainResidueDetails
AASP454
DASP454
DILE489
DASN709
AILE489
AASN709
BASP454
BILE489
BASN709
CASP454
CILE489
CASN709

site_idSWS_FT_FI8
Number of Residues4
DetailsBINDING:
ChainResidueDetails
ATHR482
BTHR482
CTHR482
DTHR482

site_idSWS_FT_FI9
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:25103405
ChainResidueDetails
AVAL484
DVAL484
DPHE658
DPHE659
APHE658
APHE659
BVAL484
BPHE658
BPHE659
CVAL484
CPHE658
CPHE659

site_idSWS_FT_FI10
Number of Residues12
DetailsSITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
ChainResidueDetails
ATHR457
DTHR457
DILE664
DGLN756
AILE664
AGLN756
BTHR457
BILE664
BGLN756
CTHR457
CILE664
CGLN756

site_idSWS_FT_FI11
Number of Residues4
DetailsSITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
ChainResidueDetails
AGLU637
BGLU637
CGLU637
DGLU637

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
ChainResidueDetails
AVAL666
BVAL666
CVAL666
DVAL666

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
ChainResidueDetails
ATYR700
BTYR700
CTYR700
DTYR700

site_idSWS_FT_FI14
Number of Residues8
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
APRO593
AARG819
BPRO593
BARG819
CPRO593
CARG819
DPRO593
DARG819

site_idSWS_FT_FI15
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873
ChainResidueDetails
AGLU239
BGLU239
CGLU239
DGLU239

site_idSWS_FT_FI16
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405
ChainResidueDetails
AASN353
BASN353
CASN353
DASN353

site_idSWS_FT_FI17
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AGLY389
AVAL396
BGLY389
BVAL396
CGLY389
CVAL396
DGLY389
DVAL396

218853

PDB entries from 2024-04-24

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