4U1R
ATP-bound structure of human platelet phosphofructokinase in an R-state, crystal form II
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003872 | molecular_function | 6-phosphofructokinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005945 | cellular_component | 6-phosphofructokinase complex |
A | 0006002 | biological_process | fructose 6-phosphate metabolic process |
A | 0006096 | biological_process | glycolytic process |
A | 0016020 | cellular_component | membrane |
A | 0016208 | molecular_function | AMP binding |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0044877 | molecular_function | protein-containing complex binding |
A | 0045296 | molecular_function | cadherin binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0048029 | molecular_function | monosaccharide binding |
A | 0061621 | biological_process | canonical glycolysis |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070095 | molecular_function | fructose-6-phosphate binding |
A | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
B | 0003872 | molecular_function | 6-phosphofructokinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005945 | cellular_component | 6-phosphofructokinase complex |
B | 0006002 | biological_process | fructose 6-phosphate metabolic process |
B | 0006096 | biological_process | glycolytic process |
B | 0016020 | cellular_component | membrane |
B | 0016208 | molecular_function | AMP binding |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0044877 | molecular_function | protein-containing complex binding |
B | 0045296 | molecular_function | cadherin binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0048029 | molecular_function | monosaccharide binding |
B | 0061621 | biological_process | canonical glycolysis |
B | 0070062 | cellular_component | extracellular exosome |
B | 0070095 | molecular_function | fructose-6-phosphate binding |
B | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
C | 0003872 | molecular_function | 6-phosphofructokinase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005945 | cellular_component | 6-phosphofructokinase complex |
C | 0006002 | biological_process | fructose 6-phosphate metabolic process |
C | 0006096 | biological_process | glycolytic process |
C | 0016020 | cellular_component | membrane |
C | 0016208 | molecular_function | AMP binding |
C | 0016301 | molecular_function | kinase activity |
C | 0016310 | biological_process | phosphorylation |
C | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
C | 0042802 | molecular_function | identical protein binding |
C | 0044877 | molecular_function | protein-containing complex binding |
C | 0045296 | molecular_function | cadherin binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0048029 | molecular_function | monosaccharide binding |
C | 0061621 | biological_process | canonical glycolysis |
C | 0070062 | cellular_component | extracellular exosome |
C | 0070095 | molecular_function | fructose-6-phosphate binding |
C | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
D | 0003872 | molecular_function | 6-phosphofructokinase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0005945 | cellular_component | 6-phosphofructokinase complex |
D | 0006002 | biological_process | fructose 6-phosphate metabolic process |
D | 0006096 | biological_process | glycolytic process |
D | 0016020 | cellular_component | membrane |
D | 0016208 | molecular_function | AMP binding |
D | 0016301 | molecular_function | kinase activity |
D | 0016310 | biological_process | phosphorylation |
D | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
D | 0042802 | molecular_function | identical protein binding |
D | 0044877 | molecular_function | protein-containing complex binding |
D | 0045296 | molecular_function | cadherin binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0048029 | molecular_function | monosaccharide binding |
D | 0061621 | biological_process | canonical glycolysis |
D | 0070062 | cellular_component | extracellular exosome |
D | 0070095 | molecular_function | fructose-6-phosphate binding |
D | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | binding site for residue ATP A 801 |
Chain | Residue |
A | SER32 |
A | ASP128 |
A | GLY129 |
A | SER130 |
A | GLY133 |
A | GLY33 |
A | GLY34 |
A | TYR64 |
A | ARG97 |
A | CYS98 |
A | PHE101 |
A | ARG102 |
A | GLY127 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue PO4 A 802 |
Chain | Residue |
A | GLY233 |
A | LYS264 |
A | ARG430 |
A | ARG434 |
A | GLY467 |
A | GLY468 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue PO4 A 803 |
Chain | Residue |
A | ARG576 |
A | ARG665 |
B | ALA420 |
B | ARG481 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue PO4 A 804 |
Chain | Residue |
A | ARG44 |
A | ARG48 |
A | SER83 |
A | SER84 |
A | GLY599 |
A | ARG632 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue PO4 A 805 |
Chain | Residue |
A | ARG481 |
A | HIS671 |
B | ARG576 |
B | ARG665 |
site_id | AC6 |
Number of Residues | 13 |
Details | binding site for residue ATP B 801 |
Chain | Residue |
B | GLY33 |
B | GLY34 |
B | TYR64 |
B | ARG97 |
B | CYS98 |
B | PHE101 |
B | ARG102 |
B | GLY127 |
B | ASP128 |
B | GLY129 |
B | SER130 |
B | GLY133 |
B | ASP177 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue PO4 B 802 |
Chain | Residue |
B | GLY233 |
B | LYS264 |
B | ARG430 |
B | ARG434 |
B | GLY467 |
B | GLY468 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue PO4 B 803 |
Chain | Residue |
B | ARG44 |
B | ARG48 |
B | SER83 |
B | SER84 |
B | LYS567 |
B | GLY599 |
B | ARG632 |
site_id | AC9 |
Number of Residues | 12 |
Details | binding site for residue ATP C 801 |
Chain | Residue |
C | SER32 |
C | GLY34 |
C | TYR64 |
C | ARG97 |
C | CYS98 |
C | PHE101 |
C | ARG102 |
C | GLY127 |
C | ASP128 |
C | GLY129 |
C | SER130 |
C | GLY133 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue PO4 C 802 |
Chain | Residue |
C | GLY233 |
C | LYS264 |
C | ARG430 |
C | ARG434 |
C | GLY467 |
C | GLY468 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue PO4 C 803 |
Chain | Residue |
C | ARG665 |
D | ALA420 |
D | ARG481 |
D | HIS671 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue PO4 C 804 |
Chain | Residue |
C | ARG44 |
C | ARG48 |
C | SER83 |
C | SER84 |
C | GLY599 |
C | ARG632 |
site_id | AD4 |
Number of Residues | 4 |
Details | binding site for residue PO4 C 805 |
Chain | Residue |
C | ARG481 |
C | HIS671 |
D | ARG576 |
D | ARG665 |
site_id | AD5 |
Number of Residues | 12 |
Details | binding site for residue ATP D 801 |
Chain | Residue |
D | GLY129 |
D | SER130 |
D | ASP175 |
D | ASP177 |
D | GLY33 |
D | TYR64 |
D | ARG97 |
D | CYS98 |
D | PHE101 |
D | ARG102 |
D | GLY127 |
D | ASP128 |
site_id | AD6 |
Number of Residues | 6 |
Details | binding site for residue PO4 D 802 |
Chain | Residue |
D | GLY233 |
D | LYS264 |
D | ARG430 |
D | ARG434 |
D | GLY467 |
D | GLY468 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue PO4 D 803 |
Chain | Residue |
D | ARG44 |
D | ARG48 |
D | SER83 |
D | SER84 |
D | LYS567 |
D | GLY599 |
D | ARG632 |
Functional Information from PROSITE/UniProt
site_id | PS00433 |
Number of Residues | 19 |
Details | PHOSPHOFRUCTOKINASE Phosphofructokinase signature. RvtilGHvQRGGtpsafDR |
Chain | Residue | Details |
A | ARG301-ARG319 | |
A | ARG665-ARG683 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03184 |
Chain | Residue | Details |
A | ASP175 | |
B | ASP175 | |
C | ASP175 | |
D | ASP175 |
site_id | SWS_FT_FI2 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03184 |
Chain | Residue | Details |
A | GLY34 | |
B | ARG97 | |
B | GLY127 | |
B | ASP128 | |
B | ARG210 | |
B | ARG301 | |
B | ARG576 | |
B | ARG665 | |
C | GLY34 | |
C | ARG97 | |
C | GLY127 | |
A | ARG97 | |
C | ASP128 | |
C | ARG210 | |
C | ARG301 | |
C | ARG576 | |
C | ARG665 | |
D | GLY34 | |
D | ARG97 | |
D | GLY127 | |
D | ASP128 | |
D | ARG210 | |
A | GLY127 | |
D | ARG301 | |
D | ARG576 | |
D | ARG665 | |
A | ASP128 | |
A | ARG210 | |
A | ARG301 | |
A | ARG576 | |
A | ARG665 | |
B | GLY34 |
site_id | SWS_FT_FI3 |
Number of Residues | 40 |
Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03184 |
Chain | Residue | Details |
A | SER173 | |
A | ARG744 | |
B | SER173 | |
B | MET217 | |
B | GLU273 | |
B | HIS307 | |
B | ARG481 | |
B | THR538 | |
B | MET583 | |
B | GLU639 | |
B | HIS671 | |
A | MET217 | |
B | ARG744 | |
C | SER173 | |
C | MET217 | |
C | GLU273 | |
C | HIS307 | |
C | ARG481 | |
C | THR538 | |
C | MET583 | |
C | GLU639 | |
C | HIS671 | |
A | GLU273 | |
C | ARG744 | |
D | SER173 | |
D | MET217 | |
D | GLU273 | |
D | HIS307 | |
D | ARG481 | |
D | THR538 | |
D | MET583 | |
D | GLU639 | |
D | HIS671 | |
A | HIS307 | |
D | ARG744 | |
A | ARG481 | |
A | THR538 | |
A | MET583 | |
A | GLU639 | |
A | HIS671 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P47860 |
Chain | Residue | Details |
A | SER142 | |
B | SER142 | |
C | SER142 | |
D | SER142 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:33607258, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER386 | |
B | SER386 | |
C | SER386 | |
D | SER386 |
site_id | SWS_FT_FI6 |
Number of Residues | 12 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS395 | |
D | LYS395 | |
D | LYS486 | |
D | LYS688 | |
A | LYS486 | |
A | LYS688 | |
B | LYS395 | |
B | LYS486 | |
B | LYS688 | |
C | LYS395 | |
C | LYS486 | |
C | LYS688 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
Chain | Residue | Details |
A | TYR651 | |
B | TYR651 | |
C | TYR651 | |
D | TYR651 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250 |
Chain | Residue | Details |
A | SER540 | |
B | SER540 | |
C | SER540 | |
D | SER540 |