4U1O

GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue KAI A 301

Chain	Residue
A	TYR61
A	HOH552
A	HOH553
A	HOH554
A	PRO89
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	GLU193

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site_id	AC2
Number of Residues	15
Details	binding site for residue FWF A 302

Chain	Residue
A	ILE92
A	ILE92
A	LYS104
A	LYS104
A	PRO105
A	PRO105
A	SER217
A	SER217
A	LYS218
A	LYS218
A	GLY219
A	GLY219
A	LEU239
A	LEU239
A	SER242

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3

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