4U1B

HsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CO A 401

Chain	Residue
A	ASP240
A	HIS303
A	GLU336
A	GLU367
A	CO402
A	Q08404

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site_id	AC2
Number of Residues	5
Details	binding site for residue CO A 402

Chain	Residue
A	CO401
A	Q08404
A	ASP229
A	ASP240
A	GLU367

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site_id	AC3
Number of Residues	9
Details	binding site for residue GOL A 403

Chain	Residue
A	THR172
A	THR204
A	SER205
A	VAL206
A	VAL209
A	ILE214
A	ASP216
A	HOH554
A	HOH575

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site_id	AC4
Number of Residues	13
Details	binding site for residue Q08 A 404

Chain	Residue
A	PHE198
A	HIS212
A	ASP229
A	THR231
A	ASP240
A	HIS303
A	HIS310
A	GLU336
A	GLU367
A	CO401
A	CO402
A	HOH668
A	HOH669

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Functional Information from PROSITE/UniProt

site_id	PS00680
Number of Residues	19
Details	MAP_1 Methionine aminopeptidase subfamily 1 signature. YcGHGIHklfHtapnVp.HY

Chain	Residue	Details
A	TYR300-TYR318

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03174","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16724298","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16823043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17114291","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03174","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16274222","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16724298","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16823043","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17114291","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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