Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4U0Z

Eukaryotic Fic Domain containing protein with bound APCPP

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue APC A 501

Chain	Residue
A	VAL316
A	ARG374
A	TYR399
A	TYR400
A	LEU403
A	GLU404
A	ASN407
A	MG502
A	HOH669
A	HIS319
A	VAL360
A	HIS363
A	ASP367
A	GLY368
A	ASN369
A	GLY370
A	ARG371

site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 502

Chain	Residue
A	GLU234
A	APC501
A	HOH696

site_id	AC3
Number of Residues	16
Details	binding site for residue APC B 501

Chain	Residue
B	VAL316
B	HIS319
B	VAL360
B	HIS363
B	ASP367
B	GLY368
B	ASN369
B	GLY370
B	ARG371
B	ARG374
B	TYR399
B	TYR400
B	LEU403
B	GLU404
B	ASN407
B	MG502

site_id	AC4
Number of Residues	4
Details	binding site for residue MG B 502

Chain	Residue
B	ASP367
B	APC501
B	HOH700
B	HOH701

site_id	AC5
Number of Residues	17
Details	binding site for residue APC C 501

Chain	Residue
C	VAL316
C	HIS319
C	VAL360
C	HIS363
C	ASP367
C	GLY368
C	ASN369
C	GLY370
C	ARG371
C	ARG374
C	TYR399
C	TYR400
C	LEU403
C	ASN407
C	MG502
C	HOH695
C	HOH713

site_id	AC6
Number of Residues	5
Details	binding site for residue MG C 502

Chain	Residue
C	ASP367
C	ARG371
C	APC501
C	HOH713
C	HOH714

site_id	AC7
Number of Residues	15
Details	binding site for residue APC D 501

Chain	Residue
D	VAL316
D	HIS319
D	VAL360
D	HIS363
D	ASP367
D	GLY368
D	ASN369
D	GLY370
D	ARG371
D	ARG374
D	TYR399
D	TYR400
D	ASN407
D	MG502
D	HOH665

site_id	AC8
Number of Residues	4
Details	binding site for residue MG D 502

Chain	Residue
D	ASP367
D	APC501
D	HOH685
D	HOH686

site_id	AC9
Number of Residues	15
Details	binding site for residue APC E 501

Chain	Residue
E	VAL316
E	HIS319
E	VAL360
E	HIS363
E	ASP367
E	GLY368
E	ASN369
E	GLY370
E	ARG371
E	ARG374
E	TYR399
E	TYR400
E	LEU403
E	ASN407
E	MG502

site_id	AD1
Number of Residues	4
Details	binding site for residue MG E 502

Chain	Residue
E	HOH676
E	ASP367
E	APC501
E	HOH667

site_id	AD2
Number of Residues	19
Details	binding site for residue APC F 501

Chain	Residue
F	VAL316
F	HIS319
F	VAL360
F	HIS363
F	ASP367
F	GLY368
F	ASN369
F	GLY370
F	ARG371
F	ARG374
F	TYR399
F	TYR400
F	LEU403
F	GLU404
F	ASN407
F	MG502
F	HOH619
F	HOH632
F	HOH696

site_id	AD3
Number of Residues	2
Details	binding site for residue MG F 502

Chain	Residue
F	APC501
F	HOH696

site_id	AD4
Number of Residues	17
Details	binding site for residue APC G 501

Chain	Residue
G	VAL316
G	HIS319
G	VAL360
G	HIS363
G	ASP367
G	GLY368
G	ASN369
G	GLY370
G	ARG371
G	ARG374
G	TYR399
G	TYR400
G	LEU403
G	GLU404
G	ASN407
G	MG502
G	HOH612

site_id	AD5
Number of Residues	4
Details	binding site for residue MG G 502

Chain	Residue
G	ASP367
G	APC501
G	HOH727
G	HOH728

site_id	AD6
Number of Residues	16
Details	binding site for residue APC H 501

Chain	Residue
H	VAL316
H	HIS319
H	VAL360
H	HIS363
H	ASP367
H	GLY368
H	ASN369
H	GLY370
H	ARG371
H	ARG374
H	TYR399
H	TYR400
H	LEU403
H	ASN407
H	MG502
H	HOH698

site_id	AD7
Number of Residues	4
Details	binding site for residue MG H 502

Chain	Residue
H	GLU234
H	APC501
H	HOH698
H	HOH699

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	231
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	264
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1080
Details	Domain: {"description":"Fido","evidences":[{"source":"PROSITE-ProRule","id":"PRU00791","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Motif: {"description":"Inhibitory (S/T)XXXE(G/N) motif","evidences":[{"source":"PubMed","id":"22266942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PubMed","id":"22266942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0U","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U07","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Site: {"description":"Important for autoinhibition of adenylyltransferase activity","evidences":[{"source":"PubMed","id":"22266942","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"O-AMP-threonine; by autocatalysis","evidences":[{"source":"PubMed","id":"25601083","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25601083","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)