4TY9

An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001172	biological_process	RNA-templated transcription
A	0003689	molecular_function	DNA clamp loader activity
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0004386	molecular_function	helicase activity
A	0006338	biological_process	chromatin remodeling
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication
A	0061775	molecular_function	cohesin loader activity
A	0140584	molecular_function	chromatin extrusion motor activity
A	0140588	biological_process	chromatin looping
A	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
A	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
B	0000166	molecular_function	nucleotide binding
B	0001172	biological_process	RNA-templated transcription
B	0003689	molecular_function	DNA clamp loader activity
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0004386	molecular_function	helicase activity
B	0006338	biological_process	chromatin remodeling
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0039694	biological_process	viral RNA genome replication
B	0061775	molecular_function	cohesin loader activity
B	0140584	molecular_function	chromatin extrusion motor activity
B	0140588	biological_process	chromatin looping
B	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
B	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
C	0000166	molecular_function	nucleotide binding
C	0001172	biological_process	RNA-templated transcription
C	0003689	molecular_function	DNA clamp loader activity
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-dependent RNA polymerase activity
C	0004386	molecular_function	helicase activity
C	0006338	biological_process	chromatin remodeling
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0034062	molecular_function	5'-3' RNA polymerase activity
C	0039694	biological_process	viral RNA genome replication
C	0061775	molecular_function	cohesin loader activity
C	0140584	molecular_function	chromatin extrusion motor activity
C	0140588	biological_process	chromatin looping
C	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
C	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
D	0000166	molecular_function	nucleotide binding
D	0001172	biological_process	RNA-templated transcription
D	0003689	molecular_function	DNA clamp loader activity
D	0003723	molecular_function	RNA binding
D	0003968	molecular_function	RNA-dependent RNA polymerase activity
D	0004386	molecular_function	helicase activity
D	0006338	biological_process	chromatin remodeling
D	0006508	biological_process	proteolysis
D	0008236	molecular_function	serine-type peptidase activity
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0039694	biological_process	viral RNA genome replication
D	0061775	molecular_function	cohesin loader activity
D	0140584	molecular_function	chromatin extrusion motor activity
D	0140588	biological_process	chromatin looping
D	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
D	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue 3B0 A 601

Chain	Residue
A	GLU361
A	ASN369
A	SER371
A	SER478
A	GLU481
A	ARG484

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