4TXZ

Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with nonhydrolyzable GTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0009117	biological_process	nucleotide metabolic process
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0009405	biological_process	obsolete pathogenesis
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0046872	molecular_function	metal ion binding
A	0050922	biological_process	negative regulation of chemotaxis
A	0051607	biological_process	defense response to virus
A	0052621	molecular_function	diguanylate cyclase activity
A	0140701	molecular_function	3',3'-cyclic GMP-AMP synthase activity
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0009117	biological_process	nucleotide metabolic process
B	0009190	biological_process	cyclic nucleotide biosynthetic process
B	0009405	biological_process	obsolete pathogenesis
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0046872	molecular_function	metal ion binding
B	0050922	biological_process	negative regulation of chemotaxis
B	0051607	biological_process	defense response to virus
B	0052621	molecular_function	diguanylate cyclase activity
B	0140701	molecular_function	3',3'-cyclic GMP-AMP synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 501

Chain	Residue
A	ASP132
A	ASP134
A	ASP194
A	G2P503

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 502

Chain	Residue
A	SER115
A	ASP132
A	ASP134
A	G2P503

---

site_id	AC3
Number of Residues	14
Details	binding site for residue G2P A 503

Chain	Residue
A	GLY114
A	SER115
A	TYR118
A	ASP132
A	ASP134
A	PRO262
A	LYS288
A	SER302
A	ASP346
A	ASP349
A	LEU353
A	MG501
A	MG502
A	GLN113

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MG B 501

Chain	Residue
B	ASP132
B	ASP134
B	ASP194

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MG B 502

Chain	Residue
B	SER115
B	ASP132
B	ASP134
B	G2P503

---

site_id	AC6
Number of Residues	13
Details	binding site for residue G2P B 503

Chain	Residue
B	GLN113
B	GLY114
B	SER115
B	TYR118
B	ASP132
B	ASP134
B	PRO262
B	LYS288
B	SER302
B	ASP349
B	LEU353
B	MG502
B	HOH601

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TXY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TXZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TY0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25131990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25201413","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XJ5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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