4TXH

Crystal structure of uridine phosphorylase from Schistosoma mansoni in APO form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006218	biological_process	uridine catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0044206	biological_process	UMP salvage
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006218	biological_process	uridine catabolic process
B	0009116	biological_process	nucleoside metabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0044206	biological_process	UMP salvage
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006218	biological_process	uridine catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0042802	molecular_function	identical protein binding
C	0044206	biological_process	UMP salvage
D	0003824	molecular_function	catalytic activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006218	biological_process	uridine catabolic process
D	0009116	biological_process	nucleoside metabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0042802	molecular_function	identical protein binding
D	0044206	biological_process	UMP salvage

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 A 301

Chain	Residue
A	CYS45
A	GLY46
A	ARG50
A	ARG121
A	GLY123
A	THR124
A	HOH417
B	ARG77

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site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 B 301

Chain	Residue
B	CYS45
B	GLY46
B	ARG50
B	ARG121
B	GLY123
B	THR124
B	HOH418
A	ARG77

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q16831

Chain	Residue	Details
A	GLY46
D	GLY46
D	ARG77
D	ARG121
A	ARG77
A	ARG121
B	GLY46
B	ARG77
B	ARG121
C	GLY46
C	ARG77
C	ARG121

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:26898674, ECO:0007744|PDB:4TXJ, ECO:0007744|PDB:4TXL, ECO:0007744|PDB:4TXM, ECO:0007744|PDB:4TXN

Chain	Residue	Details
A	SER125
B	SER125
C	SER125
D	SER125

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:26898674, ECO:0007744|PDB:4TXJ, ECO:0007744|PDB:4TXL, ECO:0007744|PDB:4TXN

Chain	Residue	Details
A	GLN201
B	GLN201
C	GLN201
D	GLN201

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