Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4TQO

The crystal structure of methanol dehydrogenase from Methylococcus capsulatus (Bath)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0046872	molecular_function	metal ion binding
B	0005509	molecular_function	calcium ion binding
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
B	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0046872	molecular_function	metal ion binding
C	0005509	molecular_function	calcium ion binding
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0046872	molecular_function	metal ion binding
D	0005509	molecular_function	calcium ion binding
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
D	0030288	cellular_component	outer membrane-bounded periplasmic space
D	0046872	molecular_function	metal ion binding
E	0005509	molecular_function	calcium ion binding
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
E	0030288	cellular_component	outer membrane-bounded periplasmic space
E	0046872	molecular_function	metal ion binding
F	0005509	molecular_function	calcium ion binding
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
F	0030288	cellular_component	outer membrane-bounded periplasmic space
F	0046872	molecular_function	metal ion binding
G	0005509	molecular_function	calcium ion binding
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
G	0030288	cellular_component	outer membrane-bounded periplasmic space
G	0046872	molecular_function	metal ion binding
H	0005509	molecular_function	calcium ion binding
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
H	0030288	cellular_component	outer membrane-bounded periplasmic space
H	0046872	molecular_function	metal ion binding
I	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
I	0015945	biological_process	methanol metabolic process
I	0015946	biological_process	methanol oxidation
I	0016491	molecular_function	oxidoreductase activity
I	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
J	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
J	0015945	biological_process	methanol metabolic process
J	0015946	biological_process	methanol oxidation
J	0016491	molecular_function	oxidoreductase activity
J	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
K	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
K	0015945	biological_process	methanol metabolic process
K	0015946	biological_process	methanol oxidation
K	0016491	molecular_function	oxidoreductase activity
K	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
L	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
L	0015945	biological_process	methanol metabolic process
L	0015946	biological_process	methanol oxidation
L	0016491	molecular_function	oxidoreductase activity
L	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
M	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
M	0015945	biological_process	methanol metabolic process
M	0015946	biological_process	methanol oxidation
M	0016491	molecular_function	oxidoreductase activity
M	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
N	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
N	0015945	biological_process	methanol metabolic process
N	0015946	biological_process	methanol oxidation
N	0016491	molecular_function	oxidoreductase activity
N	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
O	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
O	0015945	biological_process	methanol metabolic process
O	0015946	biological_process	methanol oxidation
O	0016491	molecular_function	oxidoreductase activity
O	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity
P	0004022	molecular_function	alcohol dehydrogenase (NAD+) activity
P	0015945	biological_process	methanol metabolic process
P	0015946	biological_process	methanol oxidation
P	0016491	molecular_function	oxidoreductase activity
P	0052933	molecular_function	alcohol dehydrogenase (cytochrome c(L)) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA B 701

Chain	Residue
B	GLU205
B	ASN289
B	ASP331
B	PQQ702

site_id	AC2
Number of Residues	20
Details	binding site for residue PQQ B 702

Chain	Residue
B	GLY203
B	ALA204
B	GLU205
B	THR269
B	TRP271
B	ASN289
B	ASP331
B	ARG358
B	ASN421
B	TRP497
B	GLY560
B	TRP561
B	CA701
B	HOH981
B	HOH1034
B	GLU83
B	VAL135
B	ARG137
B	THR187
B	ALA202

site_id	AC3
Number of Residues	4
Details	binding site for residue CA A 701

Chain	Residue
A	GLU205
A	ASN289
A	ASP331
A	PQQ702

site_id	AC4
Number of Residues	19
Details	binding site for residue PQQ A 702

Chain	Residue
A	GLU83
A	CYS132
A	ARG137
A	THR187
A	ALA202
A	GLY203
A	ALA204
A	GLU205
A	THR269
A	TRP271
A	ASN289
A	ASP331
A	ARG358
A	ASN421
A	TRP497
A	GLY560
A	TRP561
A	CA701
A	HOH832

site_id	AC5
Number of Residues	4
Details	binding site for residue CA C 701

Chain	Residue
C	GLU205
C	ASN289
C	ASP331
C	PQQ702

site_id	AC6
Number of Residues	19
Details	binding site for residue PQQ C 702

Chain	Residue
C	GLU83
C	VAL135
C	ARG137
C	THR187
C	ALA202
C	GLY203
C	ALA204
C	GLU205
C	THR269
C	TRP271
C	ASN289
C	ASP331
C	ARG358
C	ASN421
C	TRP497
C	GLY560
C	TRP561
C	CA701
C	HOH879

site_id	AC7
Number of Residues	4
Details	binding site for residue CA D 701

Chain	Residue
D	GLU205
D	ASN289
D	ASP331
D	PQQ702

site_id	AC8
Number of Residues	18
Details	binding site for residue PQQ D 702

Chain	Residue
D	GLU83
D	VAL135
D	ARG137
D	THR187
D	ALA202
D	GLY203
D	ALA204
D	GLU205
D	THR269
D	TRP271
D	ASP331
D	ARG358
D	ASN421
D	TRP497
D	GLY560
D	TRP561
D	CA701
D	HOH849

site_id	AC9
Number of Residues	4
Details	binding site for residue CA E 701

Chain	Residue
E	GLU205
E	ASN289
E	ASP331
E	PQQ702

site_id	AD1
Number of Residues	18
Details	binding site for residue PQQ E 702

Chain	Residue
E	THR187
E	ALA202
E	GLY203
E	ALA204
E	GLU205
E	THR269
E	TRP271
E	ASN289
E	ASP331
E	ARG358
E	TRP497
E	GLY560
E	TRP561
E	CA701
E	HOH929
E	GLU83
E	VAL135
E	ARG137

site_id	AD2
Number of Residues	4
Details	binding site for residue CA F 701

Chain	Residue
F	GLU205
F	ASN289
F	ASP331
F	PQQ702

site_id	AD3
Number of Residues	20
Details	binding site for residue PQQ F 702

Chain	Residue
F	GLU83
F	VAL135
F	ARG137
F	THR187
F	ALA202
F	GLY203
F	ALA204
F	GLU205
F	THR269
F	TRP271
F	ASN289
F	ASP331
F	ARG358
F	ASN421
F	TRP497
F	GLY560
F	TRP561
F	CA701
F	HOH868
F	HOH919

site_id	AD4
Number of Residues	4
Details	binding site for residue CA G 701

Chain	Residue
G	GLU205
G	ASN289
G	ASP331
G	PQQ702

site_id	AD5
Number of Residues	19
Details	binding site for residue PQQ G 702

Chain	Residue
G	GLU83
G	CYS132
G	VAL135
G	ARG137
G	THR187
G	ALA202
G	GLY203
G	ALA204
G	GLU205
G	THR269
G	TRP271
G	ASN289
G	ASP331
G	ARG358
G	ASN421
G	TRP497
G	GLY560
G	TRP561
G	CA701

site_id	AD6
Number of Residues	4
Details	binding site for residue CA H 701

Chain	Residue
H	GLU205
H	ASN289
H	ASP331
H	PQQ702

site_id	AD7
Number of Residues	19
Details	binding site for residue PQQ H 702

Chain	Residue
H	GLU83
H	VAL135
H	ARG137
H	THR187
H	ALA202
H	GLY203
H	ALA204
H	GLU205
H	THR269
H	TRP271
H	ASN289
H	ASP331
H	ARG358
H	ASN421
H	TRP497
H	GLY560
H	TRP561
H	CA701
H	HOH878

Functional Information from PROSITE/UniProt

site_id	PS00364
Number of Residues	22
Details	BACTERIAL_PQQ_2 Bacterial quinoprotein dehydrogenases signature 2. WgwyaYDpklDMIYYgsGnpAP

Chain	Residue	Details
B	TRP271-PRO292

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)