4TQD

Crystal Structure of the C-terminal domain of IFRS bound with 3-iodo-L-Phe and ATP

?

Functional Information from GO Data

ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0004812molecular_functionaminoacyl-tRNA ligase activity
A0005524molecular_functionATP binding
A0000049molecular_functiontRNA binding
A0006418biological_processtRNA aminoacylation for protein translation
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC15binding site for residue MG A 501
ChainResidue
AATP504
AHOH654
AHOH670
AHOH671
AHOH717

AC26binding site for residue MG A 502
ChainResidue
AGLU396
ASER399
AMG503
AATP504
AHOH663
AHOH714

AC36binding site for residue MG A 503
ChainResidue
AGLU396
AMG502
AATP504
AHOH714
AHOH715
AHOH716

AC423binding site for residue ATP A 504
ChainResidue
AARG330
AGLU332
AHIS338
ALEU339
APHE342
AGLU396
ALEU397
ASER398
ASER399
AGLY421
AGLY423
AARG426
AMG501
AMG502
AMG503
A33S505
AEDO511
AHOH654
AHOH663
AHOH665
AHOH670
AHOH671
AHOH717

AC513binding site for residue 33S A 505
ChainResidue
AMET300
ALEU301
AALA302
AARG330
AMET344
ASER346
AILE348
ASER399
AVAL401
ATRP417
AALA420
AGLY421
AATP504

AC66binding site for residue EDO A 506
ChainResidue
AASN241
AARG439
AALA440
AASN448
AGLY449
AHOH610

AC75binding site for residue EDO A 507
ChainResidue
ATYR242
ALYS245
AGLU249
ALYS431
AHIS432

AC83binding site for residue EDO A 508
ChainResidue
AASP256
AARG257
AHIS369

AC95binding site for residue EDO A 509
ChainResidue
AASP373
APHE374
ALYS375
AHIS392
AGLY393

AD17binding site for residue EDO A 510
ChainResidue
AASP313
AMET350
AGLY412
AILE413
AASP414
ALYS415
AHOH676

AD26binding site for residue EDO A 511
ChainResidue
AHIS338
AASP394
ALEU395
AGLU396
AARG426
AATP504

AD36binding site for residue EDO A 512
ChainResidue
ATYR272
AASN307
AARG310
ALYS311
AGLU357
AGLU444

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
EDO_4tqd_A_506121,2-ETHANEDIOL binding site
ChainResidueligand
AASN241-LEU243EDO: 1,2-ETHANEDIOL
ALEU428EDO: 1,2-ETHANEDIOL
APHE434EDO: 1,2-ETHANEDIOL
AARG439-ALA441EDO: 1,2-ETHANEDIOL
ATYR446-GLY449EDO: 1,2-ETHANEDIOL

EDO_4tqd_A_50771,2-ETHANEDIOL binding site
ChainResidueligand
ATYR242EDO: 1,2-ETHANEDIOL
ALYS245-LEU246EDO: 1,2-ETHANEDIOL
AGLU249EDO: 1,2-ETHANEDIOL
ALEU428EDO: 1,2-ETHANEDIOL
ALYS431-HIS432EDO: 1,2-ETHANEDIOL

EDO_4tqd_A_50861,2-ETHANEDIOL binding site
ChainResidueligand
AGLU249EDO: 1,2-ETHANEDIOL
AARG252-PHE253EDO: 1,2-ETHANEDIOL
AASP256-ARG257EDO: 1,2-ETHANEDIOL
AHIS369EDO: 1,2-ETHANEDIOL

33S_4tqd_A_505173-iodo-L-phenylalanine binding site
ChainResidueligand
AMET300-ALA30233S: 3-iodo-L-phenylalanine
ALEU305-TYR30633S: 3-iodo-L-phenylalanine
AARG33033S: 3-iodo-L-phenylalanine
AMET34433S: 3-iodo-L-phenylalanine
ASER346-ILE34833S: 3-iodo-L-phenylalanine
ASER399-VAL40133S: 3-iodo-L-phenylalanine
ATRP41733S: 3-iodo-L-phenylalanine
AGLY419-GLY42133S: 3-iodo-L-phenylalanine

EDO_4tqd_A_51081,2-ETHANEDIOL binding site
ChainResidueligand
ALEU309-ARG310EDO: 1,2-ETHANEDIOL
AASP313EDO: 1,2-ETHANEDIOL
AMET350EDO: 1,2-ETHANEDIOL
AGLY412-LYS415EDO: 1,2-ETHANEDIOL

ATP_4tqd_A_50418ADENOSINE-5'-TRIPHOSPHATE binding site
ChainResidueligand
AARG330ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLU332ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLU337-GLU340ATP: ADENOSINE-5'-TRIPHOSPHATE
APHE342ATP: ADENOSINE-5'-TRIPHOSPHATE
AMET344ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLU396-SER399ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLY421-GLY423ATP: ADENOSINE-5'-TRIPHOSPHATE
AGLU425-ARG426ATP: ADENOSINE-5'-TRIPHOSPHATE
AILE437ATP: ADENOSINE-5'-TRIPHOSPHATE

EDO_4tqd_A_51171,2-ETHANEDIOL binding site
ChainResidueligand
AGLU337-HIS338EDO: 1,2-ETHANEDIOL
AMET391EDO: 1,2-ETHANEDIOL
AASP394-GLU396EDO: 1,2-ETHANEDIOL
AARG426EDO: 1,2-ETHANEDIOL

EDO_4tqd_A_51211,2-ETHANEDIOL binding site
ChainResidueligand
AGLU357EDO: 1,2-ETHANEDIOL

EDO_4tqd_A_50961,2-ETHANEDIOL binding site
ChainResidueligand
AASP373-LYS375EDO: 1,2-ETHANEDIOL
AMET391-GLY393EDO: 1,2-ETHANEDIOL

?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
?

Catalytic Information from CSA

site_idNumber of ResiduesDetails