4TQC
The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003723 | molecular_function | RNA binding |
A | 0003743 | molecular_function | translation initiation factor activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006413 | biological_process | translational initiation |
B | 0003723 | molecular_function | RNA binding |
B | 0003743 | molecular_function | translation initiation factor activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006413 | biological_process | translational initiation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | binding site for residue M7G A 301 |
Chain | Residue |
A | TRP56 |
A | HOH573 |
B | THR55 |
A | MET101 |
A | TRP102 |
A | GLU103 |
A | ARG157 |
A | LYS162 |
A | HOH425 |
A | HOH470 |
A | HOH508 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue 34J A 302 |
Chain | Residue |
A | PHE47 |
A | LYS49 |
A | ASN59 |
A | ARG61 |
A | HIS78 |
A | SER82 |
A | HOH427 |
site_id | AC3 |
Number of Residues | 12 |
Details | binding site for residue M7G B 1000 |
Chain | Residue |
A | THR55 |
B | TRP56 |
B | MET101 |
B | TRP102 |
B | GLU103 |
B | ARG157 |
B | LYS162 |
B | HOH1126 |
B | HOH1169 |
B | HOH1185 |
B | HOH1259 |
B | HOH1300 |
Functional Information from PROSITE/UniProt
site_id | PS00813 |
Number of Residues | 24 |
Details | IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW |
Chain | Residue | Details |
A | ASP90-TRP113 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 28 |
Details | Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"11879179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12975586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Site: {"description":"(Microbial infection) Interaction with potato virus Y VPg","evidences":[{"source":"PubMed","id":"31712417","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |