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4TQC

The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003743molecular_functiontranslation initiation factor activity
A0005737cellular_componentcytoplasm
A0006413biological_processtranslational initiation
B0003723molecular_functionRNA binding
B0003743molecular_functiontranslation initiation factor activity
B0005737cellular_componentcytoplasm
B0006413biological_processtranslational initiation
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue M7G A 301
ChainResidue
ATRP56
AHOH573
BTHR55
AMET101
ATRP102
AGLU103
AARG157
ALYS162
AHOH425
AHOH470
AHOH508

site_idAC2
Number of Residues7
Detailsbinding site for residue 34J A 302
ChainResidue
APHE47
ALYS49
AASN59
AARG61
AHIS78
ASER82
AHOH427

site_idAC3
Number of Residues12
Detailsbinding site for residue M7G B 1000
ChainResidue
ATHR55
BTRP56
BMET101
BTRP102
BGLU103
BARG157
BLYS162
BHOH1126
BHOH1169
BHOH1185
BHOH1259
BHOH1300

Functional Information from PROSITE/UniProt
site_idPS00813
Number of Residues24
DetailsIF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW
ChainResidueDetails
AASP90-TRP113

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsRegion: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11879179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12975586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsSite: {"description":"(Microbial infection) Interaction with potato virus Y VPg","evidences":[{"source":"PubMed","id":"31712417","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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