4TQ0

Crystal structure of human ATG5-ATG16N69

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000423	biological_process	mitophagy
A	0001974	biological_process	blood vessel remodeling
A	0002376	biological_process	immune system process
A	0002718	biological_process	regulation of cytokine production involved in immune response
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0005930	cellular_component	axoneme
A	0006325	biological_process	chromatin organization
A	0006914	biological_process	autophagy
A	0006915	biological_process	apoptotic process
A	0006995	biological_process	cellular response to nitrogen starvation
A	0009267	biological_process	cellular response to starvation
A	0009410	biological_process	response to xenobiotic stimulus
A	0009620	biological_process	response to fungus
A	0010040	biological_process	response to iron(II) ion
A	0010659	biological_process	cardiac muscle cell apoptotic process
A	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
A	0016020	cellular_component	membrane
A	0016236	biological_process	macroautophagy
A	0016567	biological_process	protein ubiquitination
A	0019776	molecular_function	Atg8-family ligase activity
A	0019883	biological_process	antigen processing and presentation of endogenous antigen
A	0030424	cellular_component	axon
A	0030670	cellular_component	phagocytic vesicle membrane
A	0031397	biological_process	negative regulation of protein ubiquitination
A	0032480	biological_process	negative regulation of type I interferon production
A	0032991	cellular_component	protein-containing complex
A	0034045	cellular_component	phagophore assembly site membrane
A	0034274	cellular_component	Atg12-Atg5-Atg16 complex
A	0034727	biological_process	piecemeal microautophagy of the nucleus
A	0035973	biological_process	aggrephagy
A	0039689	biological_process	negative stranded viral RNA replication
A	0042311	biological_process	vasodilation
A	0043066	biological_process	negative regulation of apoptotic process
A	0043687	biological_process	post-translational protein modification
A	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
A	0045060	biological_process	negative thymic T cell selection
A	0045824	biological_process	negative regulation of innate immune response
A	0048840	biological_process	otolith development
A	0050687	biological_process	negative regulation of defense response to virus
A	0050765	biological_process	negative regulation of phagocytosis
A	0051279	biological_process	regulation of release of sequestered calcium ion into cytosol
A	0051649	biological_process	establishment of localization in cell
A	0055015	biological_process	ventricular cardiac muscle cell development
A	0060047	biological_process	heart contraction
A	0061684	biological_process	chaperone-mediated autophagy
A	0061908	cellular_component	phagophore
A	0062029	biological_process	positive regulation of stress granule assembly
A	0070254	biological_process	mucus secretion
A	0070257	biological_process	positive regulation of mucus secretion
A	0071500	biological_process	cellular response to nitrosative stress
A	1901096	biological_process	regulation of autophagosome maturation
A	1902017	biological_process	regulation of cilium assembly
A	1902617	biological_process	response to fluoride
A	1904093	biological_process	negative regulation of autophagic cell death
A	1904973	biological_process	positive regulation of viral translation
A	1990234	cellular_component	transferase complex
A	2000377	biological_process	regulation of reactive oxygen species metabolic process
A	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
B	0000045	biological_process	autophagosome assembly
C	0000045	biological_process	autophagosome assembly
C	0000423	biological_process	mitophagy
C	0001974	biological_process	blood vessel remodeling
C	0002376	biological_process	immune system process
C	0002718	biological_process	regulation of cytokine production involved in immune response
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005776	cellular_component	autophagosome
C	0005829	cellular_component	cytosol
C	0005930	cellular_component	axoneme
C	0006325	biological_process	chromatin organization
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006995	biological_process	cellular response to nitrogen starvation
C	0009267	biological_process	cellular response to starvation
C	0009410	biological_process	response to xenobiotic stimulus
C	0009620	biological_process	response to fungus
C	0010040	biological_process	response to iron(II) ion
C	0010659	biological_process	cardiac muscle cell apoptotic process
C	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
C	0016020	cellular_component	membrane
C	0016236	biological_process	macroautophagy
C	0016567	biological_process	protein ubiquitination
C	0019776	molecular_function	Atg8-family ligase activity
C	0019883	biological_process	antigen processing and presentation of endogenous antigen
C	0030424	cellular_component	axon
C	0030670	cellular_component	phagocytic vesicle membrane
C	0031397	biological_process	negative regulation of protein ubiquitination
C	0032480	biological_process	negative regulation of type I interferon production
C	0032991	cellular_component	protein-containing complex
C	0034045	cellular_component	phagophore assembly site membrane
C	0034274	cellular_component	Atg12-Atg5-Atg16 complex
C	0034727	biological_process	piecemeal microautophagy of the nucleus
C	0035973	biological_process	aggrephagy
C	0039689	biological_process	negative stranded viral RNA replication
C	0042311	biological_process	vasodilation
C	0043066	biological_process	negative regulation of apoptotic process
C	0043687	biological_process	post-translational protein modification
C	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
C	0045060	biological_process	negative thymic T cell selection
C	0045824	biological_process	negative regulation of innate immune response
C	0048840	biological_process	otolith development
C	0050687	biological_process	negative regulation of defense response to virus
C	0050765	biological_process	negative regulation of phagocytosis
C	0051279	biological_process	regulation of release of sequestered calcium ion into cytosol
C	0051649	biological_process	establishment of localization in cell
C	0055015	biological_process	ventricular cardiac muscle cell development
C	0060047	biological_process	heart contraction
C	0061684	biological_process	chaperone-mediated autophagy
C	0061908	cellular_component	phagophore
C	0062029	biological_process	positive regulation of stress granule assembly
C	0070254	biological_process	mucus secretion
C	0070257	biological_process	positive regulation of mucus secretion
C	0071500	biological_process	cellular response to nitrosative stress
C	1901096	biological_process	regulation of autophagosome maturation
C	1902017	biological_process	regulation of cilium assembly
C	1902617	biological_process	response to fluoride
C	1904093	biological_process	negative regulation of autophagic cell death
C	1904973	biological_process	positive regulation of viral translation
C	1990234	cellular_component	transferase complex
C	2000377	biological_process	regulation of reactive oxygen species metabolic process
C	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
D	0000045	biological_process	autophagosome assembly
E	0000045	biological_process	autophagosome assembly
E	0000423	biological_process	mitophagy
E	0001974	biological_process	blood vessel remodeling
E	0002376	biological_process	immune system process
E	0002718	biological_process	regulation of cytokine production involved in immune response
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005776	cellular_component	autophagosome
E	0005829	cellular_component	cytosol
E	0005930	cellular_component	axoneme
E	0006325	biological_process	chromatin organization
E	0006914	biological_process	autophagy
E	0006915	biological_process	apoptotic process
E	0006995	biological_process	cellular response to nitrogen starvation
E	0009267	biological_process	cellular response to starvation
E	0009410	biological_process	response to xenobiotic stimulus
E	0009620	biological_process	response to fungus
E	0010040	biological_process	response to iron(II) ion
E	0010659	biological_process	cardiac muscle cell apoptotic process
E	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
E	0016020	cellular_component	membrane
E	0016236	biological_process	macroautophagy
E	0016567	biological_process	protein ubiquitination
E	0019776	molecular_function	Atg8-family ligase activity
E	0019883	biological_process	antigen processing and presentation of endogenous antigen
E	0030424	cellular_component	axon
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031397	biological_process	negative regulation of protein ubiquitination
E	0032480	biological_process	negative regulation of type I interferon production
E	0032991	cellular_component	protein-containing complex
E	0034045	cellular_component	phagophore assembly site membrane
E	0034274	cellular_component	Atg12-Atg5-Atg16 complex
E	0034727	biological_process	piecemeal microautophagy of the nucleus
E	0035973	biological_process	aggrephagy
E	0039689	biological_process	negative stranded viral RNA replication
E	0042311	biological_process	vasodilation
E	0043066	biological_process	negative regulation of apoptotic process
E	0043687	biological_process	post-translational protein modification
E	0044233	cellular_component	mitochondria-associated endoplasmic reticulum membrane contact site
E	0045060	biological_process	negative thymic T cell selection
E	0045824	biological_process	negative regulation of innate immune response
E	0048840	biological_process	otolith development
E	0050687	biological_process	negative regulation of defense response to virus
E	0050765	biological_process	negative regulation of phagocytosis
E	0051279	biological_process	regulation of release of sequestered calcium ion into cytosol
E	0051649	biological_process	establishment of localization in cell
E	0055015	biological_process	ventricular cardiac muscle cell development
E	0060047	biological_process	heart contraction
E	0061684	biological_process	chaperone-mediated autophagy
E	0061908	cellular_component	phagophore
E	0062029	biological_process	positive regulation of stress granule assembly
E	0070254	biological_process	mucus secretion
E	0070257	biological_process	positive regulation of mucus secretion
E	0071500	biological_process	cellular response to nitrosative stress
E	1901096	biological_process	regulation of autophagosome maturation
E	1902017	biological_process	regulation of cilium assembly
E	1902617	biological_process	response to fluoride
E	1904093	biological_process	negative regulation of autophagic cell death
E	1904973	biological_process	positive regulation of viral translation
E	1990234	cellular_component	transferase complex
E	2000377	biological_process	regulation of reactive oxygen species metabolic process
E	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
F	0000045	biological_process	autophagosome assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET1
C	MET1
E	MET1

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12) => ECO:0000305

Chain	Residue	Details
E	LYS130
C	LYS130
A	LYS130

---