4TPR

Structure of Tau5 antibody Fab fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0019814	cellular_component	immunoglobulin complex
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue PG4 L 301

Chain	Residue
H	GLN43
L	LEU9
L	TYR92
L	GLY105
L	LYS147
L	PG4302
L	HOH545
L	HOH561

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site_id	AC2
Number of Residues	6
Details	binding site for residue PG4 L 302

Chain	Residue
L	LYS147
L	ILE149
L	TRP168
L	PG4301
L	HOH498
H	GLU42

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site_id	AC3
Number of Residues	4
Details	binding site for residue CL L 303

Chain	Residue
L	LEU15
L	LEU15
L	ARG82
L	ARG82

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site_id	AC4
Number of Residues	2
Details	binding site for residue CL L 304

Chain	Residue
H	33O304
L	ARG113

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site_id	AC5
Number of Residues	2
Details	binding site for residue PGE L 305

Chain	Residue
L	SER70
L	LYS79

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site_id	AC6
Number of Residues	6
Details	binding site for residue NA L 306

Chain	Residue
H	HOH436
L	ALA117
L	PRO118
L	THR119
L	ASN142
L	ASN143

---

site_id	AC7
Number of Residues	6
Details	binding site for residue PEG L 307

Chain	Residue
L	GLY71
L	SER72
L	ASP156
L	ARG193
L	ASN195
L	HOH401

---

site_id	AC8
Number of Residues	3
Details	binding site for residue PEG L 308

Chain	Residue
L	LYS50
L	GLY62
L	GLU86

---

site_id	AC9
Number of Residues	5
Details	binding site for residue PEG L 309

Chain	Residue
H	GLU42
L	ASN166
L	SER167
L	TRP168
L	HOH557

---

site_id	AD1
Number of Residues	11
Details	binding site for residue PEG L 310

Chain	Residue
L	HIS31
L	SER32
L	SER97
L	HIS98
L	VAL99
L	ARG160
L	GLN161
L	ASN162
L	TRS311
L	HOH402
L	HOH467

---

site_id	AD2
Number of Residues	4
Details	binding site for residue TRS L 311

Chain	Residue
L	ASN33
L	GLY96
L	PEG310
L	HOH402

---

site_id	AD3
Number of Residues	2
Details	binding site for residue CL H 301

Chain	Residue
H	TRP47
L	PHE103

---

site_id	AD4
Number of Residues	4
Details	binding site for residue CL H 302

Chain	Residue
H	SER164
H	ASN204
H	LYS213
H	HOH429

---

site_id	AD5
Number of Residues	6
Details	binding site for residue CL H 303

Chain	Residue
H	LYS151
H	GLY152
H	GLN179
H	TYR183
H	THR184
H	HOH542

---

site_id	AD6
Number of Residues	28
Details	binding site for residue 33O H 304

Chain	Residue
H	MET143
H	ASN163
H	SER164
H	SER166
H	LEU167
H	GLY170
H	THR190
H	VAL191
H	THR195
H	THR200
H	THR202
H	LYS213
H	ASP215
H	HOH416
H	HOH419
H	HOH422
H	HOH436
H	HOH470
H	HOH528
H	HOH530
L	ASP115
L	ALA116
L	ALA117
L	ASN143
L	THR205
L	SER206
L	CL304
L	HOH405

---

site_id	AD7
Number of Residues	3
Details	binding site for residue PEG H 305

Chain	Residue
H	HOH556
H	PRO41
H	THR116

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR197-HIS203

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