4TMX
Translation initiation factor eIF5B (517-858) mutant D533N from C. thermophilum, bound to GTP and sodium
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | binding site for residue GTP A 901 |
| Chain | Residue |
| A | VAL532 |
| A | ILE556 |
| A | THR557 |
| A | GLY597 |
| A | ASN648 |
| A | LYS649 |
| A | ASP651 |
| A | ARG652 |
| A | SER716 |
| A | ALA717 |
| A | HIS718 |
| A | ASN533 |
| A | NA902 |
| A | MG903 |
| A | HOH1085 |
| A | HOH1086 |
| A | HOH1089 |
| A | HOH1110 |
| A | HOH1200 |
| A | HOH1272 |
| A | HOH1307 |
| A | HOH1395 |
| A | THR534 |
| A | GLY535 |
| A | LYS536 |
| A | THR537 |
| A | LYS538 |
| A | GLN549 |
| A | GLY555 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 902 |
| Chain | Residue |
| A | ASN533 |
| A | GLY555 |
| A | ILE556 |
| A | GTP901 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 903 |
| Chain | Residue |
| A | THR537 |
| A | THR557 |
| A | GTP901 |
| A | HOH1085 |
| A | HOH1086 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 904 |
| Chain | Residue |
| A | VAL576 |
| A | VAL577 |
| A | LYS579 |
| A | ASN662 |
| A | GLY663 |
| A | GLU666 |
| A | HOH1094 |
| A | HOH1365 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 905 |
| Chain | Residue |
| A | LYS673 |
| A | GLN676 |
| A | ARG680 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 906 |
| Chain | Residue |
| A | GLU678 |
| A | ASN681 |
| A | HOH1063 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 907 |
| Chain | Residue |
| A | CYS734 |
| A | GLN735 |
| A | MET738 |
| A | SER740 |
| A | MET743 |
| A | HOH1265 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 908 |
| Chain | Residue |
| A | HIS598 |
| A | GLU599 |
| A | HOH1090 |
| A | HOH1204 |
| B | LYS579 |
| B | ASP580 |
| B | GLY581 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 909 |
| Chain | Residue |
| A | GLN572 |
| A | LYS573 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 910 |
| Chain | Residue |
| A | HOH1001 |
| B | LEU521 |
| B | LYS586 |
| B | HOH1012 |
| B | HOH1038 |
| site_id | AD2 |
| Number of Residues | 28 |
| Details | binding site for residue GTP B 901 |
| Chain | Residue |
| B | HOH1380 |
| B | VAL532 |
| B | ASN533 |
| B | THR534 |
| B | GLY535 |
| B | LYS536 |
| B | THR537 |
| B | LYS538 |
| B | GLN549 |
| B | GLY555 |
| B | ILE556 |
| B | THR557 |
| B | GLY597 |
| B | ASN648 |
| B | LYS649 |
| B | ASP651 |
| B | ARG652 |
| B | SER716 |
| B | ALA717 |
| B | HIS718 |
| B | NA902 |
| B | MG903 |
| B | HOH1088 |
| B | HOH1089 |
| B | HOH1091 |
| B | HOH1179 |
| B | HOH1199 |
| B | HOH1279 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 902 |
| Chain | Residue |
| B | ASN533 |
| B | GLY555 |
| B | ILE556 |
| B | GTP901 |
| B | HOH1089 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 903 |
| Chain | Residue |
| B | THR537 |
| B | THR557 |
| B | GTP901 |
| B | HOH1088 |
| B | HOH1089 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue EDO B 904 |
| Chain | Residue |
| B | VAL532 |
| B | ASN533 |
| B | THR534 |
| B | ASP620 |
| B | HIS623 |
| B | GLU626 |
| B | LYS649 |
| B | HOH1162 |
| B | HOH1247 |
| B | HOH1388 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 905 |
| Chain | Residue |
| B | PRO642 |
| B | PHE643 |
| B | ARG708 |
| B | VAL710 |
| B | ARG737 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 906 |
| Chain | Residue |
| A | HIS813 |
| B | TYR701 |
| B | GLU702 |
| B | ASN703 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 907 |
| Chain | Residue |
| B | LEU748 |
| B | GLY772 |
| B | ILE773 |
| B | ARG775 |
| B | HOH1141 |
| B | HOH1180 |
| B | HOH1384 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 908 |
| Chain | Residue |
| B | ARG794 |
| B | SER826 |
| B | ALA827 |
| B | PRO828 |
| B | HOH1147 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 909 |
| Chain | Residue |
| B | PRO799 |
| B | ALA800 |
| B | ARG803 |
| B | GLY809 |
| B | GLN810 |
| B | HOH1184 |
| B | HOH1224 |
| B | HOH1264 |
| B | HOH1419 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 910 |
| Chain | Residue |
| B | ALA562 |
| B | THR563 |
| B | THR798 |
| B | PRO799 |
| B | LEU805 |
| B | GLN821 |
| B | GLY822 |
| B | HOH1113 |
| B | HOH1420 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue ACY B 911 |
| Chain | Residue |
| B | TYR564 |
| B | PRO801 |
| B | GLN821 |
| B | HOH1113 |
| B | HOH1382 |
| B | HOH1405 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 442 |
| Details | Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24686316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TMV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25225612","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
