Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4TLV

CARDS TOXIN, NICKED

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0008289	molecular_function	lipid binding
A	0009986	cellular_component	cell surface
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0033099	cellular_component	attachment organelle
A	0044075	biological_process	symbiont-mediated perturbation of host vacuole organization
A	0044164	cellular_component	host cell cytosol
A	0044165	cellular_component	host cell endoplasmic reticulum
A	0090729	molecular_function	toxin activity
A	0141079	biological_process	symbiont-mediated activation of host inflammasome-mediated signal transduction
B	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0008289	molecular_function	lipid binding
B	0009986	cellular_component	cell surface
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0033099	cellular_component	attachment organelle
B	0044075	biological_process	symbiont-mediated perturbation of host vacuole organization
B	0044164	cellular_component	host cell cytosol
B	0044165	cellular_component	host cell endoplasmic reticulum
B	0090729	molecular_function	toxin activity
B	0141079	biological_process	symbiont-mediated activation of host inflammasome-mediated signal transduction
C	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0008289	molecular_function	lipid binding
C	0009986	cellular_component	cell surface
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0033099	cellular_component	attachment organelle
C	0044075	biological_process	symbiont-mediated perturbation of host vacuole organization
C	0044164	cellular_component	host cell cytosol
C	0044165	cellular_component	host cell endoplasmic reticulum
C	0090729	molecular_function	toxin activity
C	0141079	biological_process	symbiont-mediated activation of host inflammasome-mediated signal transduction
D	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0008289	molecular_function	lipid binding
D	0009986	cellular_component	cell surface
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0033099	cellular_component	attachment organelle
D	0044075	biological_process	symbiont-mediated perturbation of host vacuole organization
D	0044164	cellular_component	host cell cytosol
D	0044165	cellular_component	host cell endoplasmic reticulum
D	0090729	molecular_function	toxin activity
D	0141079	biological_process	symbiont-mediated activation of host inflammasome-mediated signal transduction
E	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0008289	molecular_function	lipid binding
E	0009986	cellular_component	cell surface
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0033099	cellular_component	attachment organelle
E	0044075	biological_process	symbiont-mediated perturbation of host vacuole organization
E	0044164	cellular_component	host cell cytosol
E	0044165	cellular_component	host cell endoplasmic reticulum
E	0090729	molecular_function	toxin activity
E	0141079	biological_process	symbiont-mediated activation of host inflammasome-mediated signal transduction
F	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0008289	molecular_function	lipid binding
F	0009986	cellular_component	cell surface
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0033099	cellular_component	attachment organelle
F	0044075	biological_process	symbiont-mediated perturbation of host vacuole organization
F	0044164	cellular_component	host cell cytosol
F	0044165	cellular_component	host cell endoplasmic reticulum
F	0090729	molecular_function	toxin activity
F	0141079	biological_process	symbiont-mediated activation of host inflammasome-mediated signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 601

Chain	Residue
A	ARG6
A	PHE7
A	ARG145
C	MET466
C	LYS467
C	HOH703
C	HOH710

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 602

Chain	Residue
A	HOH1054
B	LYS251
B	SER265
A	LYS251
A	SER265

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 603

Chain	Residue
A	TYR263
A	VAL267
A	ALA436
A	SER438
A	HOH940
A	HOH1065

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL A 604

Chain	Residue
A	ARG102
A	ARG113
A	GLN117
A	GLU522
A	HOH982

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 605

Chain	Residue
A	LYS467
A	LEU541
A	ASN542
A	VAL584
A	HOH832
A	HOH836

site_id	AC6
Number of Residues	9
Details	binding site for residue GOL A 606

Chain	Residue
A	ILE58
A	ARG59
A	THR170
A	THR171
A	VAL432
A	THR433
A	MET434
A	HOH800
A	HOH823

site_id	AC7
Number of Residues	8
Details	binding site for residue ACT A 607

Chain	Residue
A	GLU156
A	ALA160
A	HIS161
A	ASP423
A	GLU424
A	HIS428
A	ALA429
A	HOH828

site_id	AC8
Number of Residues	6
Details	binding site for residue ACT A 608

Chain	Residue
A	ARG91
A	GLU95
A	TYR475
A	LEU477
A	PHE528
A	PHE588

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 B 601

Chain	Residue
B	THR342
B	GLN343
E	HIS179

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL B 602

Chain	Residue
B	TYR263
B	LEU270
B	ARG435
B	ALA436
B	SER438
B	GOL603
B	HOH808

site_id	AD2
Number of Residues	8
Details	binding site for residue GOL B 603

Chain	Residue
A	HOH940
B	LEU270
B	GLU271
B	ASP272
B	LYS326
B	ARG435
B	GOL602
B	HOH788

site_id	AD3
Number of Residues	5
Details	binding site for residue GOL B 604

Chain	Residue
B	ASN294
B	ASN295
B	ASP487
B	ASN488
B	HOH940

site_id	AD4
Number of Residues	6
Details	binding site for residue GOL C 601

Chain	Residue
C	TYR263
C	ALA436
C	SER438
C	GOL602
C	HOH915
C	HOH1032

site_id	AD5
Number of Residues	7
Details	binding site for residue GOL C 602

Chain	Residue
C	GLU271
C	ASP272
C	LYS326
C	ARG435
C	GOL601
C	HOH807
D	HOH845

site_id	AD6
Number of Residues	5
Details	binding site for residue GOL C 603

Chain	Residue
C	LYS467
C	LEU541
C	ASN542
C	VAL584
C	HOH812

site_id	AD7
Number of Residues	4
Details	binding site for residue GOL C 604

Chain	Residue
C	THR502
C	TYR504
C	TRP506
C	ASP507

site_id	AD8
Number of Residues	5
Details	binding site for residue GOL C 605

Chain	Residue
C	ASN295
C	ASP487
C	ASN488
C	GLN293
C	ASN294

site_id	AD9
Number of Residues	7
Details	binding site for residue GOL C 606

Chain	Residue
C	ARG547
C	ASN552
C	GLN554
C	TYR571
C	LYS573
C	HOH955
C	HOH1028

site_id	AE1
Number of Residues	6
Details	binding site for residue GOL C 607

Chain	Residue
A	HIS159
C	PHE108
C	ASP112
C	ARG113
C	GLU114
C	HOH957

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 D 601

Chain	Residue
C	LYS251
C	SER265
D	LYS251
D	SER265

site_id	AE3
Number of Residues	6
Details	binding site for residue GOL D 602

Chain	Residue
D	TYR263
D	LEU270
D	ALA436
D	SER438
D	HOH845
D	HOH981

site_id	AE4
Number of Residues	6
Details	binding site for residue GOL D 603

Chain	Residue
D	ASN32
D	PHE33
D	PHE34
D	TRP195
D	LEU207
D	SER208

site_id	AE5
Number of Residues	4
Details	binding site for residue GOL D 604

Chain	Residue
D	ARG102
D	ARG113
D	GLN117
D	GLU522

site_id	AE6
Number of Residues	8
Details	binding site for residue GOL D 605

Chain	Residue
D	LYS467
D	LEU541
D	ASN542
D	LEU583
D	VAL584
D	ASP586
D	HOH819
D	HOH864

site_id	AE7
Number of Residues	5
Details	binding site for residue GOL D 606

Chain	Residue
D	PRO54
D	THR55
D	LYS365
D	GLU381
D	GLY384

site_id	AE8
Number of Residues	6
Details	binding site for residue GOL D 607

Chain	Residue
D	ARG547
D	ASN552
D	GLN554
D	TYR571
D	LYS573
D	HOH833

site_id	AE9
Number of Residues	8
Details	binding site for residue ACT D 608

Chain	Residue
D	GLU156
D	ALA160
D	HIS161
D	ASP423
D	GLU424
D	HIS428
D	ALA429
D	HOH790

site_id	AF1
Number of Residues	6
Details	binding site for residue SO4 E 601

Chain	Residue
B	MET466
B	LYS467
B	HOH729
E	ARG6
E	PHE7
E	ARG145

site_id	AF2
Number of Residues	5
Details	binding site for residue GOL E 602

Chain	Residue
E	TYR263
E	ALA436
E	SER438
E	HOH885
E	HOH893

site_id	AF3
Number of Residues	3
Details	binding site for residue GOL E 603

Chain	Residue
E	ARG102
E	ARG113
E	GLU522

site_id	AF4
Number of Residues	6
Details	binding site for residue GOL E 604

Chain	Residue
E	ASN32
E	PHE33
E	PHE34
E	TRP195
E	LEU207
E	SER208

site_id	AF5
Number of Residues	8
Details	binding site for residue GOL E 605

Chain	Residue
E	PHE340
E	SER353
E	ASN361
E	GLN362
E	ASP470
E	GLY471
E	HOH982
E	HOH984

site_id	AF6
Number of Residues	8
Details	binding site for residue ACT E 606

Chain	Residue
E	GLU156
E	ALA160
E	HIS161
E	ASP423
E	GLU424
E	HIS428
E	ALA429
E	HOH783

site_id	AF7
Number of Residues	6
Details	binding site for residue GOL F 601

Chain	Residue
E	HOH885
F	GLU271
F	ASP272
F	LYS326
F	ARG435
F	GOL602

site_id	AF8
Number of Residues	6
Details	binding site for residue GOL F 602

Chain	Residue
F	TYR263
F	ALA436
F	SER438
F	GOL601
F	HOH791
F	HOH848

site_id	AF9
Number of Residues	4
Details	binding site for residue GOL F 603

Chain	Residue
E	HIS159
F	ASP112
F	ARG113
F	GLU114

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	408
Details	Region: {"description":"Mono-ADP ribosyltransferase (mART) domain","evidences":[{"source":"PubMed","id":"25848012","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	906
Details	Region: {"description":"D3 domain","evidences":[{"source":"PubMed","id":"25848012","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Motif: {"description":"KELED motif, involved in host ER trafficking, solvent exposed in the crystal structure","evidences":[{"source":"PubMed","id":"29362229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TLV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4TLW","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)