Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4TL7

Crystal structure of N-terminal C1 domain of KaiC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
B	0005524	molecular_function	ATP binding
C	0005524	molecular_function	ATP binding
D	0005524	molecular_function	ATP binding
E	0005524	molecular_function	ATP binding
F	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue ATP A 301

Chain	Residue
A	SER48
A	ARG218
A	ILE239
A	THR240
A	ASP241
A	MG302
A	HOH424
A	HOH432
A	HOH458
A	HOH497
A	HOH498
A	GLY49
A	HOH499
B	PHE199
B	LYS224
B	LEU225
B	ARG226
B	THR228
B	HIS230
B	HOH426
B	HOH446
A	THR50
A	GLY51
A	LYS52
A	THR53
A	LEU54
A	SER89
A	PHE90

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 302

Chain	Residue
A	THR53
A	ATP301
A	HOH497
A	HOH498
A	HOH499

site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 303

Chain	Residue
A	ARG218
A	THR238
A	ILE239

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 304

Chain	Residue
A	GLU186
A	GLU187
A	TYR188
A	HOH471

site_id	AC5
Number of Residues	27
Details	binding site for residue ATP B 301

Chain	Residue
B	SER48
B	GLY49
B	THR50
B	GLY51
B	LYS52
B	THR53
B	LEU54
B	SER89
B	PHE90
B	ARG218
B	ILE239
B	THR240
B	ASP241
B	MG302
B	HOH423
B	HOH447
B	HOH467
B	HOH493
B	HOH494
B	HOH495
C	PHE199
C	LYS224
C	LEU225
C	ARG226
C	THR228
C	HIS230
C	HOH421

site_id	AC6
Number of Residues	5
Details	binding site for residue MG B 302

Chain	Residue
B	THR53
B	ATP301
B	HOH493
B	HOH494
B	HOH495

site_id	AC7
Number of Residues	3
Details	binding site for residue CL B 303

Chain	Residue
B	ARG218
B	THR238
B	ILE239

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 B 304

Chain	Residue
B	GLU186
B	GLU187
B	TYR188
B	HOH485
B	HOH504

site_id	AC9
Number of Residues	27
Details	binding site for residue ATP C 301

Chain	Residue
C	HOH523
D	PHE199
D	LYS224
D	LEU225
D	ARG226
D	THR228
D	HIS230
D	HOH434
C	SER48
C	GLY49
C	THR50
C	GLY51
C	LYS52
C	THR53
C	LEU54
C	SER89
C	PHE90
C	ARG218
C	ILE239
C	ASP241
C	MG302
C	HOH418
C	HOH438
C	HOH500
C	HOH501
C	HOH519
C	HOH521

site_id	AD1
Number of Residues	5
Details	binding site for residue MG C 302

Chain	Residue
C	THR53
C	ATP301
C	HOH500
C	HOH501
C	HOH502

site_id	AD2
Number of Residues	3
Details	binding site for residue CL C 303

Chain	Residue
C	ARG218
C	THR238
C	ILE239

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 C 304

Chain	Residue
C	GLU186
C	GLU187
C	TYR188
C	HOH490

site_id	AD4
Number of Residues	27
Details	binding site for residue ATP D 301

Chain	Residue
D	SER48
D	GLY49
D	THR50
D	GLY51
D	LYS52
D	THR53
D	LEU54
D	SER89
D	PHE90
D	ARG218
D	ILE239
D	THR240
D	ASP241
D	MG302
D	HOH433
D	HOH452
D	HOH514
D	HOH515
D	HOH516
D	HOH543
E	PHE199
E	LYS224
E	LEU225
E	ARG226
E	THR228
E	HIS230
E	HOH424

site_id	AD5
Number of Residues	5
Details	binding site for residue MG D 302

Chain	Residue
D	THR53
D	ATP301
D	HOH514
D	HOH515
D	HOH516

site_id	AD6
Number of Residues	3
Details	binding site for residue CL D 303

Chain	Residue
D	ARG218
D	THR238
D	ILE239

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 D 304

Chain	Residue
D	GLU186
D	GLU187
D	TYR188
D	HOH483

site_id	AD8
Number of Residues	27
Details	binding site for residue ATP E 301

Chain	Residue
E	SER48
E	GLY49
E	THR50
E	GLY51
E	LYS52
E	THR53
E	LEU54
E	SER89
E	PHE90
E	ARG218
E	ILE239
E	THR240
E	ASP241
E	MG302
E	HOH425
E	HOH443
E	HOH501
E	HOH502
E	HOH503
F	PHE199
F	LYS224
F	LEU225
F	ARG226
F	THR228
F	HIS230
F	HOH405
F	HOH406

site_id	AD9
Number of Residues	5
Details	binding site for residue MG E 302

Chain	Residue
E	THR53
E	ATP301
E	HOH501
E	HOH502
E	HOH503

site_id	AE1
Number of Residues	2
Details	binding site for residue CL E 303

Chain	Residue
E	ARG218
E	ILE239

site_id	AE2
Number of Residues	5
Details	binding site for residue SO4 E 304

Chain	Residue
E	GLU186
E	GLU187
E	TYR188
E	HOH449
E	HOH484

site_id	AE3
Number of Residues	25
Details	binding site for residue ATP F 301

Chain	Residue
A	PHE199
A	LYS224
A	LEU225
A	ARG226
A	THR228
A	HIS230
A	HOH428
F	SER48
F	GLY49
F	THR50
F	GLY51
F	LYS52
F	THR53
F	LEU54
F	SER89
F	PHE90
F	ARG218
F	ILE239
F	ASP241
F	MG302
F	HOH408
F	HOH424
F	HOH486
F	HOH487
F	HOH488

site_id	AE4
Number of Residues	5
Details	binding site for residue MG F 302

Chain	Residue
F	THR53
F	ATP301
F	HOH486
F	HOH487
F	HOH488

site_id	AE5
Number of Residues	2
Details	binding site for residue CL F 303

Chain	Residue
F	ARG218
F	ILE239

site_id	AE6
Number of Residues	3
Details	binding site for residue SO4 F 304

Chain	Residue
F	GLU186
F	GLU187
F	TYR188

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton acceptor in CI (KaiC 1) => ECO:0000305\|PubMed:22304631

Chain	Residue	Details
A	GLU77
B	GLU77
C	GLU77
D	GLU77
E	GLU77
F	GLU77

site_id	SWS_FT_FI2
Number of Residues	72
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01836, ECO:0000269\|PubMed:15304218, ECO:0000269\|PubMed:16628225, ECO:0000269\|PubMed:22304631, ECO:0007744\|PDB:1TF7, ECO:0007744\|PDB:2GBL, ECO:0007744\|PDB:4DUG

Chain	Residue	Details
A	GLY49
A	HIS230
A	THR240
A	ASP241
B	GLY49
B	THR50
B	GLY51
B	LYS52
B	LEU54
B	SER89
B	LYS224
A	THR50
B	ARG226
B	THR228
B	HIS230
B	THR240
B	ASP241
C	GLY49
C	THR50
C	GLY51
C	LYS52
C	LEU54
A	GLY51
C	SER89
C	LYS224
C	ARG226
C	THR228
C	HIS230
C	THR240
C	ASP241
D	GLY49
D	THR50
D	GLY51
A	LYS52
D	LYS52
D	LEU54
D	SER89
D	LYS224
D	ARG226
D	THR228
D	HIS230
D	THR240
D	ASP241
E	GLY49
A	LEU54
E	THR50
E	GLY51
E	LYS52
E	LEU54
E	SER89
E	LYS224
E	ARG226
E	THR228
E	HIS230
E	THR240
A	SER89
E	ASP241
F	GLY49
F	THR50
F	GLY51
F	LYS52
F	LEU54
F	SER89
F	LYS224
F	ARG226
F	THR228
A	LYS224
F	HIS230
F	THR240
F	ASP241
A	ARG226
A	THR228

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01836, ECO:0007744\|PDB:4DUG, ECO:0007744\|PDB:4TL6, ECO:0007744\|PDB:7DXQ

Chain	Residue	Details
A	THR53
B	THR53
C	THR53
D	THR53
E	THR53
F	THR53

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01836, ECO:0000269\|PubMed:15304218, ECO:0000269\|PubMed:16628225, ECO:0007744\|PDB:1TF7, ECO:0007744\|PDB:2GBL

Chain	Residue	Details
A	LEU225
B	LEU225
C	LEU225
D	LEU225
E	LEU225
F	LEU225

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)