4TKP

Complex of Ubc13 with the RING domain of the TRIM5alpha retroviral restriction factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000151	cellular_component	ubiquitin ligase complex
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000729	biological_process	DNA double-strand break processing
A	0003723	molecular_function	RNA binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006282	biological_process	regulation of DNA repair
A	0006301	biological_process	postreplication repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0006974	biological_process	DNA damage response
A	0016567	biological_process	protein ubiquitination
A	0016740	molecular_function	transferase activity
A	0031371	cellular_component	ubiquitin conjugating enzyme complex
A	0031372	cellular_component	UBC13-MMS2 complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031669	biological_process	cellular response to nutrient levels
A	0032991	cellular_component	protein-containing complex
A	0038202	biological_process	TORC1 signaling
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043130	molecular_function	ubiquitin binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0045739	biological_process	positive regulation of DNA repair
A	0050852	biological_process	T cell receptor signaling pathway
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070062	cellular_component	extracellular exosome
A	0070534	biological_process	protein K63-linked ubiquitination
A	0097027	molecular_function	ubiquitin-protein transferase activator activity
A	0140374	biological_process	antiviral innate immune response
A	1902523	biological_process	positive regulation of protein K63-linked ubiquitination
A	1902533	biological_process	positive regulation of intracellular signal transduction
A	1904262	biological_process	negative regulation of TORC1 signaling
A	2000781	biological_process	positive regulation of double-strand break repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 201

Chain	Residue
A	PHE57
A	PRO59
A	GLU60
A	ARG70
A	ARG85

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 101

Chain	Residue
B	CYS30
B	HIS32
B	CYS56
B	CYS59

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site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 102

Chain	Residue
B	CYS15
B	CYS18
B	CYS35
B	CYS38

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Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNVdkl.GrICLdiL

Chain	Residue	Details
A	TYR76-LEU91

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site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHsFCqaCI

Chain	Residue	Details
B	CYS30-ILE39

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
B	CYS15-ARG60

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q9C035

Chain	Residue	Details
B	ALA2

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9C035

Chain	Residue	Details
B	SER87

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