Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE LSD A 301 |
| Chain | Residue |
| A | ASP170 |
| A | TRP270 |
| A | HOH437 |
| B | HIS232 |
| B | HOH452 |
| A | SER174 |
| A | TRP175 |
| A | TRP175 |
| A | ARG177 |
| A | HIS186 |
| A | SER224 |
| A | HIS231 |
| A | TYR251 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 302 |
| Chain | Residue |
| A | HIS146 |
| A | ASP170 |
| A | GLU197 |
| A | TYR251 |
| A | MET253 |
| A | MET266 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT A 303 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT A 304 |
| Chain | Residue |
| A | TYR14 |
| A | ASP38 |
| A | GLU65 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT A 305 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 306 |
| Chain | Residue |
| A | VAL123 |
| A | SER126 |
| A | THR129 |
| A | HOH449 |
| A | HOH451 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE LSD B 301 |
| Chain | Residue |
| A | HIS232 |
| B | ASP170 |
| B | SER174 |
| B | TRP175 |
| B | TRP175 |
| B | ARG177 |
| B | HIS186 |
| B | SER224 |
| B | LEU228 |
| B | HIS231 |
| B | LEU233 |
| B | TYR251 |
| B | HOH422 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 302 |
| Chain | Residue |
| B | HIS146 |
| B | ASP170 |
| B | GLU197 |
| B | TYR251 |
| B | MET253 |
| B | MET266 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 303 |
| Chain | Residue |
| B | THR198 |
| B | GLY200 |
| B | THR214 |
| B | SER216 |
| B | HOH423 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT B 304 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT B 305 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT B 306 |
| Chain | Residue |
| A | HIS74 |
| B | HIS232 |
| B | ALA272 |
| B | NA308 |
| B | HOH420 |
| B | HOH429 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 307 |
| Chain | Residue |
| A | HIS232 |
| B | HIS74 |
| B | NA308 |
| B | HOH419 |
| B | HOH439 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA B 308 |
| Chain | Residue |
| A | HIS232 |
| B | HIS232 |
| B | FMT306 |
| B | FMT307 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 309 |
| Chain | Residue |
| B | VAL123 |
| B | SER126 |
| B | THR129 |
| B | HOH465 |
| B | HOH466 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; for 5-exo epoxide-opening cyclization activity => ECO:0000269|PubMed:22388816 |
| Chain | Residue | Details |
| A | ASP38 | |
| B | ASP38 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; for 6-endo epoxide-opening cyclization activity => ECO:0000269|PubMed:22388816 |
| Chain | Residue | Details |
| A | ASP170 | |
| B | ASP170 | |
| Chain | Residue | Details |
| A | TYR14 | |
| B | ARG177 | |
| B | GLU197 | |
| B | TYR251 | |
| A | GLU65 | |
| A | HIS146 | |
| A | ARG177 | |
| A | GLU197 | |
| A | TYR251 | |
| B | TYR14 | |
| B | GLU65 | |
| B | HIS146 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Raises pKa of active site Asp-38 |
| Chain | Residue | Details |
| A | ARG54 | |
| B | ARG54 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Raises pKa of active site Asp-170 |
| Chain | Residue | Details |
| A | HIS186 | |
| B | HIS186 | |
