4RZM

Crystal structure of the Lsd19-lasalocid A complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016853	molecular_function	isomerase activity
A	0017000	biological_process	antibiotic biosynthetic process
B	0016853	molecular_function	isomerase activity
B	0017000	biological_process	antibiotic biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LSD A 301

Chain	Residue
A	ASP170
A	TRP270
A	HOH437
B	HIS232
B	HOH452
A	SER174
A	TRP175
A	TRP175
A	ARG177
A	HIS186
A	SER224
A	HIS231
A	TYR251

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 302

Chain	Residue
A	HIS146
A	ASP170
A	GLU197
A	TYR251
A	MET253
A	MET266

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 303

Chain	Residue
A	GLU65
A	LEU81

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 304

Chain	Residue
A	TYR14
A	ASP38
A	GLU65

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 305

Chain	Residue
A	ASP38

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 306

Chain	Residue
A	VAL123
A	SER126
A	THR129
A	HOH449
A	HOH451

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LSD B 301

Chain	Residue
A	HIS232
B	ASP170
B	SER174
B	TRP175
B	TRP175
B	ARG177
B	HIS186
B	SER224
B	LEU228
B	HIS231
B	LEU233
B	TYR251
B	HOH422

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 302

Chain	Residue
B	HIS146
B	ASP170
B	GLU197
B	TYR251
B	MET253
B	MET266

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT B 303

Chain	Residue
B	THR198
B	GLY200
B	THR214
B	SER216
B	HOH423

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT B 304

Chain	Residue
B	HIS0
B	GLU110

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT B 305

Chain	Residue
B	GLU65
B	LEU81

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT B 306

Chain	Residue
A	HIS74
B	HIS232
B	ALA272
B	NA308
B	HOH420
B	HOH429

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT B 307

Chain	Residue
A	HIS232
B	HIS74
B	NA308
B	HOH419
B	HOH439

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 308

Chain	Residue
A	HIS232
B	HIS232
B	FMT306
B	FMT307

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 309

Chain	Residue
B	VAL123
B	SER126
B	THR129
B	HOH465
B	HOH466

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor; for 5-exo epoxide-opening cyclization activity","evidences":[{"source":"PubMed","id":"22388816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor; for 6-endo epoxide-opening cyclization activity","evidences":[{"source":"PubMed","id":"22388816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22388816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Raises pKa of active site Asp-38"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Raises pKa of active site Asp-170"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	132
Details	Region: {"description":"Lsd19A"}

Chain

Residue

Details

---