Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4RYF

ClpP1/2 heterocomplex from Listeria monocytogenes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0051117	molecular_function	ATPase binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008236	molecular_function	serine-type peptidase activity
H	0009368	cellular_component	endopeptidase Clp complex
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008236	molecular_function	serine-type peptidase activity
J	0009368	cellular_component	endopeptidase Clp complex
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 301

Chain	Residue
A	LYS82
A	ILE84
A	HOH402
B	ASN192

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA B 301

Chain	Residue
B	LYS82
B	ILE84

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA C 301

Chain	Residue
C	ILE81
C	PRO86

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA D 301

Chain	Residue
D	ILE84
D	PRO86
D	ILE81

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA E 301

Chain	Residue
E	ILE81
E	LYS82
E	ILE84
E	PRO86

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA F 301

Chain	Residue
F	LYS82
F	ILE84
F	HOH409

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA G 301

Chain	Residue
G	ILE81
G	LYS82
G	ILE84
G	PRO86

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MLI H 301

Chain	Residue
H	ILE71
H	SER98
H	MET99
H	HIS123
H	MET150

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA H 302

Chain	Residue
H	MET81
H	VAL84
H	ALA86

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MLI I 301

Chain	Residue
I	SER98
I	SER101
I	PHE102
I	HIS123
I	PRO125
I	MET154

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA I 302

Chain	Residue
I	MET81
I	VAL84
I	ALA86

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MLI J 301

Chain	Residue
J	SER98
J	SER101
J	ILE122
J	HIS123
J	PRO125
J	MET154

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA J 302

Chain	Residue
J	MET81
J	VAL84
J	ALA86

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MLI K 301

Chain	Residue
K	SER98
K	SER101
K	PHE102
K	ILE122
K	HIS123
K	MET154

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA K 302

Chain	Residue
K	MET81
K	VAL84
K	ALA86

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MLI L 301

Chain	Residue
L	SER98
L	HIS123
L	PRO125

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA L 302

Chain	Residue
L	MET81
L	VAL84
L	ALA86

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MLI M 301

Chain	Residue
M	SER98
M	SER101
M	HIS123
M	PRO125
M	MET154

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA M 302

Chain	Residue
M	MET81
M	VAL84
M	ALA86

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MLI N 301

Chain	Residue
N	SER98
N	SER101
N	PHE102
N	ILE122
N	HIS123
N	MET154

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA N 302

Chain	Residue
N	MET81
N	VAL84
N	ALA86

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TigMGmAASMGS

Chain	Residue	Details
H	THR90-SER101

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfslPntrYMIHQP

Chain	Residue	Details
A	ARG112-PRO125
H	ARG112-PRO125

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
H	SER98
I	SER98
J	SER98
K	SER98
L	SER98
M	SER98
N	SER98

site_id	SWS_FT_FI2
Number of Residues	7
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00444

Chain	Residue	Details
H	HIS123
I	HIS123
J	HIS123
K	HIS123
L	HIS123
M	HIS123
N	HIS123

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)