4RW3
Structural insights into substrate binding of brown spider venom class II phospholipases D
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 301 |
| Chain | Residue |
| A | GLU32 |
| A | ASP34 |
| A | ASP92 |
| A | IPD304 |
| A | HOH410 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 302 |
| Chain | Residue |
| A | SER203 |
| A | GLY122 |
| A | ASN123 |
| A | GLY201 |
| A | LEU202 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 303 |
| Chain | Residue |
| A | TYR45 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE IPD A 304 |
| Chain | Residue |
| A | HIS12 |
| A | GLU32 |
| A | ASP34 |
| A | HIS48 |
| A | ASP92 |
| A | LYS94 |
| A | SER167 |
| A | TYR223 |
| A | TRP225 |
| A | MG301 |
| A | HOH410 |
| A | HOH441 |
| A | HOH474 |
| A | HOH485 |
| A | HOH506 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 305 |
| Chain | Residue |
| A | GLY168 |
| A | ASN169 |
| A | ASP170 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE OCA A 306 |
| Chain | Residue |
| A | ALA259 |
| A | LYS263 |
| A | PLM310 |
| A | HOH422 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SHV A 307 |
| Chain | Residue |
| A | GLY176 |
| A | ILE184 |
| A | PHE218 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE DKA A 308 |
| Chain | Residue |
| A | PRO51 |
| A | CYS52 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PLM A 309 |
| Chain | Residue |
| A | ASN196 |
| A | ASP228 |
| A | LYS229 |
| A | TYR248 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PLM A 310 |
| Chain | Residue |
| A | ASN257 |
| A | LYS262 |
| A | OCA306 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PLM A 311 |
| Chain | Residue |
| A | ASN40 |
| A | ASP105 |
| A | LYS108 |
| A | LYS109 |
| A | LYS112 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE DKA A 312 |
| Chain | Residue |
| A | LYS147 |
| A | ILE184 |
| A | HOH469 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE TDA A 313 |
| Chain | Residue |
| A | ASN138 |
| A | TYR140 |
| A | LYS181 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"25961401","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25961401","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25961401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RW3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4RW5","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
