4RTA

Cystal structure of the Dpy30 for MLL/SET1 COMPASS H3K4 trimethylation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0006325	biological_process	chromatin organization
A	0016197	biological_process	endosomal transport
A	0035097	cellular_component	histone methyltransferase complex
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044665	cellular_component	MLL1/2 complex
A	0044666	cellular_component	MLL3/4 complex
A	0045815	biological_process	transcription initiation-coupled chromatin remodeling
A	0048188	cellular_component	Set1C/COMPASS complex
A	0071339	cellular_component	MLL1 complex
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005802	cellular_component	trans-Golgi network
B	0006325	biological_process	chromatin organization
B	0016197	biological_process	endosomal transport
B	0035097	cellular_component	histone methyltransferase complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044665	cellular_component	MLL1/2 complex
B	0044666	cellular_component	MLL3/4 complex
B	0045815	biological_process	transcription initiation-coupled chromatin remodeling
B	0048188	cellular_component	Set1C/COMPASS complex
B	0071339	cellular_component	MLL1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 201

Chain	Residue
A	ASN79
A	PRO80
A	ILE81
A	GLU82
A	HOH303
A	HOH328
B	LYS92

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 202

Chain	Residue
A	ASN99
A	HOH301
A	HOH318
B	PRO80
B	FMT201
A	GLU96
A	ASP97

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT B 201

Chain	Residue
A	LYS92
A	FMT202
B	ASN79
B	PRO80
B	ILE81
B	GLU82

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	MET1
B	MET1

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER19
B	SER19

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS35
B	LYS35

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS35
B	LYS35

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