4RSQ

2.9A resolution structure of SRPN2 (K198C/E359C) from Anopheles gambiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0010951	biological_process	negative regulation of endopeptidase activity
A	0010955	biological_process	negative regulation of protein processing
A	0030414	molecular_function	peptidase inhibitor activity
A	0035009	biological_process	negative regulation of melanization defense response
A	0042832	biological_process	defense response to protozoan
A	0045087	biological_process	innate immune response
A	0045861	biological_process	negative regulation of proteolysis
A	0050776	biological_process	regulation of immune response
B	0002376	biological_process	immune system process
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0010951	biological_process	negative regulation of endopeptidase activity
B	0010955	biological_process	negative regulation of protein processing
B	0030414	molecular_function	peptidase inhibitor activity
B	0035009	biological_process	negative regulation of melanization defense response
B	0042832	biological_process	defense response to protozoan
B	0045087	biological_process	innate immune response
B	0045861	biological_process	negative regulation of proteolysis
B	0050776	biological_process	regulation of immune response
C	0002376	biological_process	immune system process
C	0004867	molecular_function	serine-type endopeptidase inhibitor activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0010951	biological_process	negative regulation of endopeptidase activity
C	0010955	biological_process	negative regulation of protein processing
C	0030414	molecular_function	peptidase inhibitor activity
C	0035009	biological_process	negative regulation of melanization defense response
C	0042832	biological_process	defense response to protozoan
C	0045087	biological_process	innate immune response
C	0045861	biological_process	negative regulation of proteolysis
C	0050776	biological_process	regulation of immune response
D	0002376	biological_process	immune system process
D	0004867	molecular_function	serine-type endopeptidase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0010951	biological_process	negative regulation of endopeptidase activity
D	0010955	biological_process	negative regulation of protein processing
D	0030414	molecular_function	peptidase inhibitor activity
D	0035009	biological_process	negative regulation of melanization defense response
D	0042832	biological_process	defense response to protozoan
D	0045087	biological_process	innate immune response
D	0045861	biological_process	negative regulation of proteolysis
D	0050776	biological_process	regulation of immune response
E	0002376	biological_process	immune system process
E	0004867	molecular_function	serine-type endopeptidase inhibitor activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0010951	biological_process	negative regulation of endopeptidase activity
E	0010955	biological_process	negative regulation of protein processing
E	0030414	molecular_function	peptidase inhibitor activity
E	0035009	biological_process	negative regulation of melanization defense response
E	0042832	biological_process	defense response to protozoan
E	0045087	biological_process	innate immune response
E	0045861	biological_process	negative regulation of proteolysis
E	0050776	biological_process	regulation of immune response
F	0002376	biological_process	immune system process
F	0004867	molecular_function	serine-type endopeptidase inhibitor activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0010951	biological_process	negative regulation of endopeptidase activity
F	0010955	biological_process	negative regulation of protein processing
F	0030414	molecular_function	peptidase inhibitor activity
F	0035009	biological_process	negative regulation of melanization defense response
F	0042832	biological_process	defense response to protozoan
F	0045087	biological_process	innate immune response
F	0045861	biological_process	negative regulation of proteolysis
F	0050776	biological_process	regulation of immune response
G	0002376	biological_process	immune system process
G	0004867	molecular_function	serine-type endopeptidase inhibitor activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0010951	biological_process	negative regulation of endopeptidase activity
G	0010955	biological_process	negative regulation of protein processing
G	0030414	molecular_function	peptidase inhibitor activity
G	0035009	biological_process	negative regulation of melanization defense response
G	0042832	biological_process	defense response to protozoan
G	0045087	biological_process	innate immune response
G	0045861	biological_process	negative regulation of proteolysis
G	0050776	biological_process	regulation of immune response
H	0002376	biological_process	immune system process
H	0004867	molecular_function	serine-type endopeptidase inhibitor activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0010951	biological_process	negative regulation of endopeptidase activity
H	0010955	biological_process	negative regulation of protein processing
H	0030414	molecular_function	peptidase inhibitor activity
H	0035009	biological_process	negative regulation of melanization defense response
H	0042832	biological_process	defense response to protozoan
H	0045087	biological_process	innate immune response
H	0045861	biological_process	negative regulation of proteolysis
H	0050776	biological_process	regulation of immune response
I	0002376	biological_process	immune system process
I	0004867	molecular_function	serine-type endopeptidase inhibitor activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0010951	biological_process	negative regulation of endopeptidase activity
I	0010955	biological_process	negative regulation of protein processing
I	0030414	molecular_function	peptidase inhibitor activity
I	0035009	biological_process	negative regulation of melanization defense response
I	0042832	biological_process	defense response to protozoan
I	0045087	biological_process	innate immune response
I	0045861	biological_process	negative regulation of proteolysis
I	0050776	biological_process	regulation of immune response
J	0002376	biological_process	immune system process
J	0004867	molecular_function	serine-type endopeptidase inhibitor activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0010951	biological_process	negative regulation of endopeptidase activity
J	0010955	biological_process	negative regulation of protein processing
J	0030414	molecular_function	peptidase inhibitor activity
J	0035009	biological_process	negative regulation of melanization defense response
J	0042832	biological_process	defense response to protozoan
J	0045087	biological_process	innate immune response
J	0045861	biological_process	negative regulation of proteolysis
J	0050776	biological_process	regulation of immune response
K	0002376	biological_process	immune system process
K	0004867	molecular_function	serine-type endopeptidase inhibitor activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0010951	biological_process	negative regulation of endopeptidase activity
K	0010955	biological_process	negative regulation of protein processing
K	0030414	molecular_function	peptidase inhibitor activity
K	0035009	biological_process	negative regulation of melanization defense response
K	0042832	biological_process	defense response to protozoan
K	0045087	biological_process	innate immune response
K	0045861	biological_process	negative regulation of proteolysis
K	0050776	biological_process	regulation of immune response
L	0002376	biological_process	immune system process
L	0004867	molecular_function	serine-type endopeptidase inhibitor activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0010951	biological_process	negative regulation of endopeptidase activity
L	0010955	biological_process	negative regulation of protein processing
L	0030414	molecular_function	peptidase inhibitor activity
L	0035009	biological_process	negative regulation of melanization defense response
L	0042832	biological_process	defense response to protozoan
L	0045087	biological_process	innate immune response
L	0045861	biological_process	negative regulation of proteolysis
L	0050776	biological_process	regulation of immune response

Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. FNANRPFIFfI

Chain	Residue	Details
A	PHE380-ILE390

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Motif: {"description":"Hinge region; required for binding to peptidase","evidences":[{"source":"PubMed","id":"25525260","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---