4ROE
Human TFIIB-related factor 2 (Brf2) and TBP bound to RPPH1 promoter
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006352 | biological_process | DNA-templated transcription initiation |
| A | 0017025 | molecular_function | TBP-class protein binding |
| A | 0070897 | biological_process | transcription preinitiation complex assembly |
| B | 0003677 | molecular_function | DNA binding |
| B | 0006352 | biological_process | DNA-templated transcription initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG N 101 |
| Chain | Residue |
| N | DA18 |
| N | HOH205 |
| N | HOH220 |
| N | HOH221 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG T 101 |
| Chain | Residue |
| T | DA17 |
| T | HOH222 |
| T | HOH227 |
| T | HOH228 |
| T | HOH234 |
Functional Information from PROSITE/UniProt
| site_id | PS00351 |
| Number of Residues | 50 |
| Details | TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePRttaLIFsSGKMvctGAKseeqsrlAarkyarvV |
| Chain | Residue | Details |
| B | TYR192-VAL241 | |
| B | TYR283-LEU332 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 161 |
| Details | Repeat: {"description":"1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 153 |
| Details | Repeat: {"description":"2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Region: {"description":"Interaction with target DNA","evidences":[{"source":"PubMed","id":"26638071","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ROC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Region: {"description":"Required for the formation of a ternary complex with DNA and TBP; not required for interaction with TBP in the absence of DNA","evidences":[{"source":"PubMed","id":"26638071","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Cysteine sulfenic acid (-SOH)","evidences":[{"source":"PubMed","id":"26638071","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IYD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
