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4RNM

Crystal structure of human polymerase eta inserting dAMPnPP opposite DNA template containing an abasic site

Functional Information from GO Data
ChainGOidnamespacecontents
A0003684molecular_functiondamaged DNA binding
A0006281biological_processDNA repair
Functional Information from PDB Data
site_idAC1
Number of Residues26
DetailsBINDING SITE FOR RESIDUE DZ4 A 501
ChainResidue
AASP13
AARG55
AARG61
AASP115
ALYS231
AMG502
AMG503
AHOH656
AHOH657
AHOH667
AHOH689
AMET14
AHOH691
AHOH733
AHOH777
AHOH779
PDT8
PHOH105
TDA5
AASP15
ACYS16
APHE17
APHE18
AILE48
AALA49
ATYR52

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 502
ChainResidue
AASP13
AMET14
AASP115
ADZ4501
AMG503

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 503
ChainResidue
AASP13
AASP115
AGLU116
ADZ4501
AMG502
AHOH667
PDT8

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 504
ChainResidue
APRO244
ASER248
AGLY276
AGLU277
AHOH670
AHOH675
AHOH703

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 505
ChainResidue
ASER257
ALYS293
AASN294
ATRP297

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:27284197, ECO:0007744|PDB:5KFO
ChainResidueDetails
AASP13
AMET14
AASP115
AGLU116

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:27284197
ChainResidueDetails
AARG61

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PDB entries from 2024-11-06

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