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4RKK

Structure of a product bound phosphatase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0001558biological_processregulation of cell growth
A0001932biological_processregulation of protein phosphorylation
A0004373molecular_functionglycogen (starch) synthase activity
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005844cellular_componentobsolete polysome
A0005886cellular_componentplasma membrane
A0005977biological_processglycogen metabolic process
A0005978biological_processglycogen biosynthetic process
A0006470biological_processprotein dephosphorylation
A0006816biological_processcalcium ion transport
A0006914biological_processautophagy
A0007005biological_processmitochondrion organization
A0007399biological_processnervous system development
A0010468biological_processregulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0014009biological_processglial cell proliferation
A0015813biological_processL-glutamate transmembrane transport
A0016055biological_processWnt signaling pathway
A0016239biological_processpositive regulation of macroautophagy
A0016311biological_processdephosphorylation
A0016791molecular_functionphosphatase activity
A0017018molecular_functionmyosin phosphatase activity
A0019203molecular_functioncarbohydrate phosphatase activity
A0030246molecular_functioncarbohydrate binding
A0030247molecular_functionpolysaccharide binding
A0030425cellular_componentdendrite
A0031396biological_processregulation of protein ubiquitination
A0033137biological_processnegative regulation of peptidyl-serine phosphorylation
A0035335biological_processpeptidyl-tyrosine dephosphorylation
A0042306biological_processregulation of protein import into nucleus
A0042325biological_processregulation of phosphorylation
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043204cellular_componentperikaryon
A0043231cellular_componentintracellular membrane-bounded organelle
A0044042biological_processglucan metabolic process
A0045786biological_processnegative regulation of cell cycle
A0046835biological_processcarbohydrate phosphorylation
A0046838biological_processobsolete phosphorylated carbohydrate dephosphorylation
A0046959biological_processhabituation
A0061136biological_processregulation of proteasomal protein catabolic process
A0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
A0098556cellular_componentcytoplasmic side of rough endoplasmic reticulum membrane
A1903076biological_processregulation of protein localization to plasma membrane
A2001069molecular_functionglycogen binding
A2001070molecular_functionstarch binding
C0000045biological_processautophagosome assembly
C0001558biological_processregulation of cell growth
C0001932biological_processregulation of protein phosphorylation
C0004373molecular_functionglycogen (starch) synthase activity
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0004725molecular_functionprotein tyrosine phosphatase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005844cellular_componentobsolete polysome
C0005886cellular_componentplasma membrane
C0005977biological_processglycogen metabolic process
C0005978biological_processglycogen biosynthetic process
C0006470biological_processprotein dephosphorylation
C0006816biological_processcalcium ion transport
C0006914biological_processautophagy
C0007005biological_processmitochondrion organization
C0007399biological_processnervous system development
C0010468biological_processregulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0014009biological_processglial cell proliferation
C0015813biological_processL-glutamate transmembrane transport
C0016055biological_processWnt signaling pathway
C0016239biological_processpositive regulation of macroautophagy
C0016311biological_processdephosphorylation
C0016791molecular_functionphosphatase activity
C0017018molecular_functionmyosin phosphatase activity
C0019203molecular_functioncarbohydrate phosphatase activity
C0030246molecular_functioncarbohydrate binding
C0030247molecular_functionpolysaccharide binding
C0030425cellular_componentdendrite
C0031396biological_processregulation of protein ubiquitination
C0033137biological_processnegative regulation of peptidyl-serine phosphorylation
C0035335biological_processpeptidyl-tyrosine dephosphorylation
C0042306biological_processregulation of protein import into nucleus
C0042325biological_processregulation of phosphorylation
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043204cellular_componentperikaryon
C0043231cellular_componentintracellular membrane-bounded organelle
C0044042biological_processglucan metabolic process
C0045786biological_processnegative regulation of cell cycle
C0046835biological_processcarbohydrate phosphorylation
C0046838biological_processobsolete phosphorylated carbohydrate dephosphorylation
C0046959biological_processhabituation
C0061136biological_processregulation of proteasomal protein catabolic process
C0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
C0098556cellular_componentcytoplasmic side of rough endoplasmic reticulum membrane
C1903076biological_processregulation of protein localization to plasma membrane
C2001069molecular_functionglycogen binding
C2001070molecular_functionstarch binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000305|PubMed:11220751, ECO:0000305|PubMed:11739371, ECO:0000305|PubMed:14532330, ECO:0000305|PubMed:22036712, ECO:0000305|PubMed:25538239, ECO:0000305|PubMed:25544560
ChainResidueDetails
ASER266
CSER266

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:25544560, ECO:0007744|PDB:4RKK
ChainResidueDetails
ATRP32
CLYS87
CGLY103
CASP197
CASP235
CARG241
CASN267
CTYR304
ALYS87
AGLY103
AASP197
AASP235
AARG241
AASN267
ATYR304
CTRP32

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Required for homodimerization => ECO:0000269|PubMed:23922729
ChainResidueDetails
ACYS329
CCYS329

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:21728993
ChainResidueDetails
ASER25
CSER25

222036

PDB entries from 2024-07-03

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