4RKK

Structure of a product bound phosphatase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004373	molecular_function	alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005844	cellular_component	obsolete polysome
A	0005886	cellular_component	plasma membrane
A	0005977	biological_process	glycogen metabolic process
A	0005978	biological_process	glycogen biosynthetic process
A	0006470	biological_process	protein dephosphorylation
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0006914	biological_process	autophagy
A	0009892	biological_process	negative regulation of metabolic process
A	0016311	biological_process	dephosphorylation
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0019203	molecular_function	carbohydrate phosphatase activity
A	0030246	molecular_function	carbohydrate binding
A	0030247	molecular_function	polysaccharide binding
A	0030425	cellular_component	dendrite
A	0035335	biological_process	peptidyl-tyrosine dephosphorylation
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043204	cellular_component	perikaryon
A	0046835	biological_process	carbohydrate phosphorylation
A	0046838	biological_process	obsolete phosphorylated carbohydrate dephosphorylation
A	0098554	cellular_component	cytoplasmic side of endoplasmic reticulum membrane
A	0098556	cellular_component	cytoplasmic side of rough endoplasmic reticulum membrane
A	2001069	molecular_function	glycogen binding
A	2001070	molecular_function	starch binding
C	0004373	molecular_function	alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
C	0004721	molecular_function	phosphoprotein phosphatase activity
C	0004722	molecular_function	protein serine/threonine phosphatase activity
C	0004725	molecular_function	protein tyrosine phosphatase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005844	cellular_component	obsolete polysome
C	0005886	cellular_component	plasma membrane
C	0005977	biological_process	glycogen metabolic process
C	0005978	biological_process	glycogen biosynthetic process
C	0006470	biological_process	protein dephosphorylation
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0006914	biological_process	autophagy
C	0009892	biological_process	negative regulation of metabolic process
C	0016311	biological_process	dephosphorylation
C	0016787	molecular_function	hydrolase activity
C	0016791	molecular_function	phosphatase activity
C	0019203	molecular_function	carbohydrate phosphatase activity
C	0030246	molecular_function	carbohydrate binding
C	0030247	molecular_function	polysaccharide binding
C	0030425	cellular_component	dendrite
C	0035335	biological_process	peptidyl-tyrosine dephosphorylation
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043204	cellular_component	perikaryon
C	0046835	biological_process	carbohydrate phosphorylation
C	0046838	biological_process	obsolete phosphorylated carbohydrate dephosphorylation
C	0098554	cellular_component	cytoplasmic side of endoplasmic reticulum membrane
C	0098556	cellular_component	cytoplasmic side of rough endoplasmic reticulum membrane
C	2001069	molecular_function	glycogen binding
C	2001070	molecular_function	starch binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	334
Details	Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Motif: {"description":"Glucan phosphatase signature motif CXAGXGR","evidences":[{"source":"PubMed","id":"25544560","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26231210","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11220751","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11739371","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"14532330","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22036712","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25538239","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25544560","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25544560","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RKK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"21728993","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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