4RJD
TFP bound in alternate orientations to calcium-saturated Calmodulin C-Domains
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 201 |
| Chain | Residue |
| A | ASP129 |
| A | ASP131 |
| A | ASP133 |
| A | GLN135 |
| A | GLU140 |
| A | HOH316 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 202 |
| Chain | Residue |
| A | TYR99 |
| A | GLU104 |
| A | HOH310 |
| A | ASP93 |
| A | ASP95 |
| A | ASN97 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TFP A 203 |
| Chain | Residue |
| A | PHE92 |
| A | LEU105 |
| A | MET109 |
| A | MET124 |
| A | ALA128 |
| A | VAL136 |
| A | MET144 |
| A | TFP204 |
| A | 1PE205 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TFP A 204 |
| Chain | Residue |
| A | LEU112 |
| A | GLU114 |
| A | TFP203 |
| A | 1PE205 |
| B | VAL91 |
| B | LEU112 |
| B | TFP204 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 1PE A 205 |
| Chain | Residue |
| A | GLU114 |
| A | TFP203 |
| A | TFP204 |
| A | OXL207 |
| B | GLU84 |
| B | ALA88 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 206 |
| Chain | Residue |
| A | ARG106 |
| A | ASP118 |
| A | HOH337 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE OXL A 207 |
| Chain | Residue |
| A | LYS115 |
| A | GLU120 |
| A | 1PE205 |
| B | GLU84 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 201 |
| Chain | Residue |
| B | ASP93 |
| B | ASP95 |
| B | ASN97 |
| B | TYR99 |
| B | GLU104 |
| B | HOH308 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 202 |
| Chain | Residue |
| B | ASP129 |
| B | ASP131 |
| B | ASP133 |
| B | GLN135 |
| B | GLU140 |
| B | HOH302 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TFP B 203 |
| Chain | Residue |
| A | LEU112 |
| B | PHE92 |
| B | MET109 |
| B | MET124 |
| B | MET144 |
| B | MET145 |
| B | TFP204 |
| site_id | BC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE TFP B 204 |
| Chain | Residue |
| A | LEU112 |
| A | GLY113 |
| A | GLU114 |
| A | TFP204 |
| B | GLU87 |
| B | MET124 |
| B | GLU127 |
| B | MET144 |
| B | TFP203 |
| B | HOH311 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SCN B 205 |
| Chain | Residue |
| B | HIS107 |
| B | GLU119 |
| B | ARG126 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGNGYISaaEL |
| Chain | Residue | Details |
| A | ASP93-LEU105 | |
| A | ASP129-PHE141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3EK4, ECO:0007744|PDB:3EK7, ECO:0007744|PDB:3EK8, ECO:0007744|PDB:3EKH, ECO:0007744|PDB:3EVR, ECO:0007744|PDB:3EVU, ECO:0007744|PDB:3SG2, ECO:0007744|PDB:3SG3, ECO:0007744|PDB:3SG4, ECO:0007744|PDB:3SG5, ECO:0007744|PDB:3SG6, ECO:0007744|PDB:3SG7, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:3WLC, ECO:0007744|PDB:3WLD, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4RJD |
| Chain | Residue | Details |
| A | ASP93 | |
| B | GLU104 | |
| A | ASP95 | |
| A | ASN97 | |
| A | TYR99 | |
| A | GLU104 | |
| B | ASP93 | |
| B | ASP95 | |
| B | ASN97 | |
| B | TYR99 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3EK7, ECO:0007744|PDB:3EK8, ECO:0007744|PDB:3EKH, ECO:0007744|PDB:3EVR, ECO:0007744|PDB:3EVU, ECO:0007744|PDB:3SG2, ECO:0007744|PDB:3SG3, ECO:0007744|PDB:3SG4, ECO:0007744|PDB:3SG5, ECO:0007744|PDB:3SG7, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:3WLC, ECO:0007744|PDB:3WLD, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4RJD |
| Chain | Residue | Details |
| A | ASP129 | |
| B | GLU140 | |
| A | ASP131 | |
| A | ASP133 | |
| A | GLN135 | |
| A | GLU140 | |
| B | ASP129 | |
| B | ASP131 | |
| B | ASP133 | |
| B | GLN135 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| A | LYS94 | |
| B | LYS94 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | TYR99 | |
| B | TYR99 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | SER101 | |
| B | SER101 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| A | THR110 | |
| B | THR110 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| A | LYS115 | |
| B | LYS115 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P0DP23 |
| Chain | Residue | Details |
| A | TYR138 | |
| B | TYR138 |
