4RJD

TFP bound in alternate orientations to calcium-saturated Calmodulin C-Domains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 201

Chain	Residue
A	ASP129
A	ASP131
A	ASP133
A	GLN135
A	GLU140
A	HOH316

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 202

Chain	Residue
A	TYR99
A	GLU104
A	HOH310
A	ASP93
A	ASP95
A	ASN97

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP A 203

Chain	Residue
A	PHE92
A	LEU105
A	MET109
A	MET124
A	ALA128
A	VAL136
A	MET144
A	TFP204
A	1PE205

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TFP A 204

Chain	Residue
A	LEU112
A	GLU114
A	TFP203
A	1PE205
B	VAL91
B	LEU112
B	TFP204

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 1PE A 205

Chain	Residue
A	GLU114
A	TFP203
A	TFP204
A	OXL207
B	GLU84
B	ALA88

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 206

Chain	Residue
A	ARG106
A	ASP118
A	HOH337

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OXL A 207

Chain	Residue
A	LYS115
A	GLU120
A	1PE205
B	GLU84

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 201

Chain	Residue
B	ASP93
B	ASP95
B	ASN97
B	TYR99
B	GLU104
B	HOH308

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 202

Chain	Residue
B	ASP129
B	ASP131
B	ASP133
B	GLN135
B	GLU140
B	HOH302

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TFP B 203

Chain	Residue
A	LEU112
B	PHE92
B	MET109
B	MET124
B	MET144
B	MET145
B	TFP204

---

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TFP B 204

Chain	Residue
A	LEU112
A	GLY113
A	GLU114
A	TFP204
B	GLU87
B	MET124
B	GLU127
B	MET144
B	TFP203
B	HOH311

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SCN B 205

Chain	Residue
B	HIS107
B	GLU119
B	ARG126

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGNGYISaaEL

Chain	Residue	Details
A	ASP93-LEU105
A	ASP129-PHE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23109337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3145979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HQW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CLN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RJD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23109337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3145979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HQW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CLN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RJD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---