4RF5

Crystal structure of ketoreductase from Lactobacillus kefir, E145S mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0008206	biological_process	bile acid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0008206	biological_process	bile acid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 301

Chain	Residue
A	GLN252
A	HOH465
A	HOH466
A	HOH467
A	HOH468
B	GLN252

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 302

Chain	Residue
A	HOH471
A	HOH472
A	HOH473
A	HOH474
A	ASP25
A	ASP180
A	HOH470

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 303

Chain	Residue
A	ASP180
A	VAL181
A	ARG182
A	LYS236
A	HOH443
A	HOH519
A	HOH543
B	MET214

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 304

Chain	Residue
A	ASP3
A	VAL28
A	GLU29
A	LYS177

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SisgfvgdptLgaYNASKGAVrIMSkSAA

Chain	Residue	Details
A	SER143-ALA171

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"26644568","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26644568","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RF2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26644568","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RF4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---