Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4REQ

Methylmalonyl-COA Mutase substrate complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004494molecular_functionmethylmalonyl-CoA mutase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0016853molecular_functionisomerase activity
A0016866molecular_functionintramolecular transferase activity
A0019678biological_processpropionate metabolic process, methylmalonyl pathway
A0031419molecular_functioncobalamin binding
A0046872molecular_functionmetal ion binding
B0003824molecular_functioncatalytic activity
B0004494molecular_functionmethylmalonyl-CoA mutase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0016853molecular_functionisomerase activity
B0016866molecular_functionintramolecular transferase activity
B0019652biological_processlactate fermentation to propionate and acetate
B0019678biological_processpropionate metabolic process, methylmalonyl pathway
B0031419molecular_functioncobalamin binding
B0046872molecular_functionmetal ion binding
C0003824molecular_functioncatalytic activity
C0004494molecular_functionmethylmalonyl-CoA mutase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0016853molecular_functionisomerase activity
C0016866molecular_functionintramolecular transferase activity
C0019678biological_processpropionate metabolic process, methylmalonyl pathway
C0031419molecular_functioncobalamin binding
C0046872molecular_functionmetal ion binding
D0003824molecular_functioncatalytic activity
D0004494molecular_functionmethylmalonyl-CoA mutase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0016853molecular_functionisomerase activity
D0016866molecular_functionintramolecular transferase activity
D0019652biological_processlactate fermentation to propionate and acetate
D0019678biological_processpropionate metabolic process, methylmalonyl pathway
D0031419molecular_functioncobalamin binding
D0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues48
DetailsBINDING SITE FOR RESIDUE B12 A 800
ChainResidue
ATYR89
AGLU247
AGLY333
ATRP334
ALEU336
AGLU370
AALA371
AALA373
ALEU374
AGLN454
ALEU602
APHE117
AGLY609
AHIS610
AASP611
AARG612
AGLY613
AILE617
ATYR621
ASER655
ALEU657
AGLY659
ALEU119
AGLY685
AGLY686
AVAL687
ATYR705
ATHR706
ATHR709
ASCA801
AMCA802
A5AD803
AHOH883
AHIS122
AHOH889
AHOH892
AHOH914
AHOH951
AHOH987
AHOH1021
AHOH1025
AHOH1072
AHOH1078
AALA139
AVAL206
AARG207
ATHR209
ATYR243

site_idAC2
Number of Residues41
DetailsBINDING SITE FOR RESIDUE SCA A 801
ChainResidue
ATYR75
ATHR77
AMET78
AARG82
ATHR85
AARG87
ATYR89
ASER114
ASER164
ATHR166
ATHR195
AGLN197
AARG207
AASN236
ATYR243
AHIS244
AARG283
ASER285
APHE287
AARG326
ATHR327
AHIS328
AGLN330
AGLN361
ASER362
AB12800
AHOH807
AHOH808
AHOH826
AHOH835
AHOH836
AHOH837
AHOH865
AHOH886
AHOH891
AHOH900
AHOH960
AHOH1028
AHOH1127
AHOH1129
BARG45

site_idAC3
Number of Residues42
DetailsBINDING SITE FOR RESIDUE MCA A 802
ChainResidue
ATHR195
AGLN197
AARG207
AASN236
ATYR243
AHIS244
AARG283
ASER285
APHE287
AARG326
AHIS328
AGLN330
AGLN361
ASER362
AB12800
A5AD803
AHOH807
AHOH808
AHOH826
AHOH835
AHOH836
AHOH837
AHOH865
AHOH886
AHOH891
AHOH900
AHOH944
AHOH960
AHOH1028
AHOH1127
AHOH1129
BARG45
ATYR75
ATHR77
AMET78
AARG82
ATHR85
AARG87
ATYR89
ASER114
ASER164
ATHR166

site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 5AD A 803
ChainResidue
ATYR89
AALA90
AGLY91
AALA116
AALA139
AGLY140
ATYR243
AGLN330
AASN366
AGLU370
ALEU374
AB12800
AMCA802
AHOH868
AHOH1074

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 1
ChainResidue
AALA41
AGLU42
ATHR251
AHOH804
AHOH912
AHOH915
AHOH1134

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL B 639
ChainResidue
BPHE93
BTHR97
BASP316
BLYS317
BARG318
BGLY319
BARG321

site_idAC7
Number of Residues49
DetailsBINDING SITE FOR RESIDUE B12 C 800
ChainResidue
CTYR89
CPHE117
CLEU119
CHIS122
CALA139
CVAL206
CARG207
CTHR209
CHIS244
CGLU247
CGLY333
CTRP334
CLEU336
CGLU370
CALA371
CALA373
CLEU374
CGLN454
CLEU602
CASP608
CGLY609
CHIS610
CASP611
CARG612
CGLY613
CILE617
CTYR621
CSER655
CLEU657
CALA658
CGLY659
CGLY685
CGLY686
CVAL687
CTYR705
CTHR706
CTHR709
CSCA801
CMCA802
C5AD803
CHOH881
CHOH887
CHOH890
CHOH949
CHOH984
CHOH1018
CHOH1022
CHOH1069
CHOH1075

site_idAC8
Number of Residues42
DetailsBINDING SITE FOR RESIDUE SCA C 801
ChainResidue
CTYR75
CTHR77
CMET78
CPHE81
CARG82
CTHR85
CARG87
CTYR89
CSER114
CSER164
CTHR166
CTHR195
CGLN197
CARG207
CASN236
CTYR243
CHIS244
CARG283
CSER285
CPHE287
CARG326
CTHR327
CHIS328
CGLN330
CGLN361
CSER362
CB12800
C5AD803
CHOH807
CHOH808
CHOH826
CHOH835
CHOH836
CHOH837
CHOH863
CHOH884
CHOH889
CHOH943
CHOH958
CHOH1025
CHOH1123
DARG45

site_idAC9
Number of Residues43
DetailsBINDING SITE FOR RESIDUE MCA C 802
ChainResidue
CTYR75
CTHR77
CMET78
CPHE81
CARG82
CTHR85
CARG87
CTYR89
CSER114
CSER164
CTHR166
CTHR195
CGLN197
CARG207
CASN236
CTYR243
CHIS244
CARG283
CSER285
CPHE287
CARG326
CTHR327
CHIS328
CGLN330
CGLN361
CSER362
CB12800
C5AD803
CHOH807
CHOH808
CHOH826
CHOH835
CHOH836
CHOH837
CHOH863
CHOH884
CHOH889
CHOH898
CHOH943
CHOH958
CHOH1025
CHOH1123
DARG45

site_idBC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 5AD C 803
ChainResidue
CTYR89
CALA90
CGLY91
CALA116
CALA139
CGLY140
CTYR243
CGLN330
CASN366
CGLU370
CLEU374
CB12800
CSCA801
CMCA802
CHOH866
CHOH1071
CHOH1162

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL C 1
ChainResidue
CALA41
CGLU42
CHOH804
CHOH910
CHOH913

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL D 639
ChainResidue
DTHR97
DASP316
DLYS317
DGLY319
DARG321

Functional Information from PROSITE/UniProt
site_idPS00544
Number of Residues26
DetailsMETMALONYL_COA_MUTASE Methylmalonyl-CoA mutase signature. RIARNTqlFLqQEsgttRviDPwSGS
ChainResidueDetails
AARG381-SER406
BARG377-SER402

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:10387043, ECO:0007744|PDB:4REQ
ChainResidueDetails
AALA76
AMET245
ALEU284
APHE286
CALA76
CTYR79
CPRO83
CILE86
CGLN88
CALA90
CVAL115
ATYR79
CILE196
CASN198
CMET245
CLEU284
CPHE286
APRO83
AILE86
AGLN88
AALA90
AVAL115
AILE196
AASN198

site_idSWS_FT_FI2
Number of Residues28
DetailsBINDING: BINDING => ECO:0000269|PubMed:10387043, ECO:0000269|PubMed:8805541, ECO:0007744|PDB:1REQ, ECO:0007744|PDB:4REQ
ChainResidueDetails
AASP118
AGLY613
ASER656
AALA658
AVAL687
AVAL710
CASP118
CGLY140
CARG207
CASN208
CTRP334
AGLY140
CALA371
CLEU374
CHIS610
CARG612
CGLY613
CSER656
CALA658
CVAL687
CVAL710
AARG207
AASN208
ATRP334
AALA371
ALEU374
AHIS610
AARG612

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:10387043, ECO:0000269|PubMed:8805541, ECO:0007744|PDB:1REQ, ECO:0007744|PDB:4REQ
ChainResidueDetails
AASP611
CASP611

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Transition state stabilizer => ECO:0000305|PubMed:9772164
ChainResidueDetails
AALA90
CALA90

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1bmt
ChainResidueDetails
AASP608
AHIS661
AHIS610

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1bmt
ChainResidueDetails
CASP608
CHIS661
CHIS610

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1bmt
ChainResidueDetails
BGLN208

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1bmt
ChainResidueDetails
DGLN208

site_idCSA5
Number of Residues5
DetailsAnnotated By Reference To The Literature 1bmt
ChainResidueDetails
AASP608
ALYS604
ATYR89
AHIS244
AHIS610

site_idCSA6
Number of Residues5
DetailsAnnotated By Reference To The Literature 1bmt
ChainResidueDetails
CASP608
CLYS604
CTYR89
CHIS244
CHIS610

site_idCSA7
Number of Residues1
DetailsAnnotated By Reference To The Literature 1bmt
ChainResidueDetails
ATYR621

site_idCSA8
Number of Residues1
DetailsAnnotated By Reference To The Literature 1bmt
ChainResidueDetails
CTYR621

site_idMCSA1
Number of Residues6
DetailsM-CSA 62
ChainResidueDetails
AALA90electrostatic stabiliser, radical stabiliser
AHIS244electrostatic stabiliser, radical stabiliser
AMET245electrostatic stabiliser, proton acceptor, proton donor
AMET605electrostatic stabiliser
AGLY609electrostatic stabiliser
AASP611metal ligand

site_idMCSA2
Number of Residues6
DetailsM-CSA 62
ChainResidueDetails
CALA90electrostatic stabiliser, radical stabiliser
CHIS244electrostatic stabiliser, radical stabiliser
CMET245electrostatic stabiliser, proton acceptor, proton donor
CMET605electrostatic stabiliser
CGLY609electrostatic stabiliser
CASP611metal ligand

227561

PDB entries from 2024-11-20

PDB statisticsPDBj update infoContact PDBjnumon