4RD2
Structure of aIF2-gamma H97A variant from Sulfolobus solfataricus bound to GDPNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0001731 | biological_process | formation of translation preinitiation complex |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0006412 | biological_process | translation |
| A | 0006413 | biological_process | translational initiation |
| A | 0006414 | biological_process | translational elongation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE GNP A 501 |
| Chain | Residue |
| A | VAL18 |
| A | GLY96 |
| A | ASN149 |
| A | LYS150 |
| A | ASP152 |
| A | VAL153 |
| A | SER184 |
| A | ALA185 |
| A | LEU186 |
| A | MG502 |
| A | HOH601 |
| A | ASP19 |
| A | HOH606 |
| A | HOH612 |
| A | HOH665 |
| A | HOH740 |
| A | HOH779 |
| A | HOH835 |
| A | HOH886 |
| A | HOH891 |
| A | HIS20 |
| A | GLY21 |
| A | LYS22 |
| A | THR23 |
| A | THR24 |
| A | MET45 |
| A | THR46 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | THR23 |
| A | THR46 |
| A | GNP501 |
| A | HOH601 |
| A | HOH612 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GNP A 503 |
| Chain | Residue |
| A | PHE221 |
| A | ASP222 |
| A | VAL223 |
| A | LYS225 |
| A | LYS234 |
| A | GLU262 |
| A | SER278 |
| A | ARG280 |
| A | GLY282 |
| A | ALA296 |
| A | GLY298 |
| A | HOH900 |
| A | HOH908 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD A 504 |
| Chain | Residue |
| A | GLU39 |
| A | LYS42 |
| A | LYS287 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:25690901, ECO:0007744|PDB:4RD1 |
| Chain | Residue | Details |
| A | ASP19 | |
| A | GLY44 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:16407071, ECO:0000269|PubMed:25690901, ECO:0007744|PDB:2AHO |
| Chain | Residue | Details |
| A | THR23 | |
| A | THR46 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8U082, ECO:0000255|HAMAP-Rule:MF_00119 |
| Chain | Residue | Details |
| A | CYS59 | |
| A | CYS62 | |
| A | CYS74 | |
| A | CYS77 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:25690901, ECO:0007744|PDB:4RCY, ECO:0007744|PDB:4RD1 |
| Chain | Residue | Details |
| A | ASN149 | |
| A | SER184 |
