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4R9U

Structure of vitamin B12 transporter BtuCD in a nucleotide-bound outward facing state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0015420molecular_functionABC-type vitamin B12 transporter activity
A0015889biological_processcobalamin transport
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0035461biological_processvitamin transmembrane transport
A0042802molecular_functionidentical protein binding
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0055085biological_processtransmembrane transport
A0090482molecular_functionvitamin transmembrane transporter activity
A1990191cellular_componentcobalamin transport complex
A1990193cellular_componentBtuCD complex
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0015420molecular_functionABC-type vitamin B12 transporter activity
B0015889biological_processcobalamin transport
B0016020cellular_componentmembrane
B0022857molecular_functiontransmembrane transporter activity
B0035461biological_processvitamin transmembrane transport
B0042802molecular_functionidentical protein binding
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0055085biological_processtransmembrane transport
B0090482molecular_functionvitamin transmembrane transporter activity
B1990191cellular_componentcobalamin transport complex
B1990193cellular_componentBtuCD complex
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0015420molecular_functionABC-type vitamin B12 transporter activity
C0015889biological_processcobalamin transport
C0016020cellular_componentmembrane
C0016887molecular_functionATP hydrolysis activity
C0019898cellular_componentextrinsic component of membrane
C0042626molecular_functionATPase-coupled transmembrane transporter activity
C0043190cellular_componentATP-binding cassette (ABC) transporter complex
C0055085biological_processtransmembrane transport
C1990191cellular_componentcobalamin transport complex
C1990193cellular_componentBtuCD complex
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005886cellular_componentplasma membrane
D0015420molecular_functionABC-type vitamin B12 transporter activity
D0015889biological_processcobalamin transport
D0016020cellular_componentmembrane
D0016887molecular_functionATP hydrolysis activity
D0019898cellular_componentextrinsic component of membrane
D0042626molecular_functionATPase-coupled transmembrane transporter activity
D0043190cellular_componentATP-binding cassette (ABC) transporter complex
D0055085biological_processtransmembrane transport
D1990191cellular_componentcobalamin transport complex
D1990193cellular_componentBtuCD complex
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE LDA A 501
ChainResidue
ATRP115
AARG189
ATRP192

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE LDA A 502
ChainResidue
ATRP188

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE LDA B 501
ChainResidue
BTRP192

site_idAC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE LDA B 502
ChainResidue
BTRP188

site_idAC5
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ANP C 301
ChainResidue
CGLY38
CLYS39
CSER40
CTHR41
CGLN80
CGLN159
CHIS191
CMG302
DARG122
DGLN126
DSER128
DGLY129
DGLY130
DGLU131
DSER163
CARG15
CASN35
CGLY36

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG C 302
ChainResidue
CSER40
CGLN80
CANP301

site_idAC7
Number of Residues16
DetailsBINDING SITE FOR RESIDUE ANP D 301
ChainResidue
CARG122
CSER128
CGLY129
CGLY130
CGLU131
CSER163
DARG15
DASN35
DGLY36
DGLY38
DLYS39
DSER40
DTHR41
DGLN80
DHIS191
DMG302

site_idAC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG D 302
ChainResidue
DSER40
DGLN80
DANP301

Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGEWQRVRLAAVV
ChainResidueDetails
CLEU127-VAL141

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01005
ChainResidueDetails
CGLY33
BGLN207-LEU228
BGLY268-VAL274
BGLY325-ARG326
DGLY33
AHIS139-SER141
AGLN207-LEU228
AGLY268-VAL274
AGLY325-ARG326
BMET1-ARG10
BGLU82-GLY92
BHIS139-SER141

site_idSWS_FT_FI2
Number of Residues48
DetailsTRANSMEM: Helical; Name=1
ChainResidueDetails
AGLN11-GLU35
BGLN11-GLU35

site_idSWS_FT_FI3
Number of Residues124
DetailsTOPO_DOM: Periplasmic => ECO:0000269|PubMed:15919996
ChainResidueDetails
AGLN36-ARG56
BALA297-PRO304
AGLY108-PRO113
ASER167-GLN190
AALA250-GLY257
AALA297-PRO304
BGLN36-ARG56
BGLY108-PRO113
BSER167-GLN190
BALA250-GLY257

site_idSWS_FT_FI4
Number of Residues48
DetailsTRANSMEM: Helical; Name=2
ChainResidueDetails
ALEU57-PHE81
BLEU57-PHE81

site_idSWS_FT_FI5
Number of Residues28
DetailsTRANSMEM: Helical; Name=3
ChainResidueDetails
AVAL93-LEU107
BVAL93-LEU107

site_idSWS_FT_FI6
Number of Residues48
DetailsTRANSMEM: Helical; Name=4
ChainResidueDetails
AASN114-ARG138
BASN114-ARG138

site_idSWS_FT_FI7
Number of Residues48
DetailsTRANSMEM: Helical; Name=5
ChainResidueDetails
ATHR142-PHE166
BTHR142-PHE166

site_idSWS_FT_FI8
Number of Residues30
DetailsTRANSMEM: Helical; Name=6
ChainResidueDetails
ASER191-SER206
BSER191-SER206

site_idSWS_FT_FI9
Number of Residues40
DetailsTRANSMEM: Helical; Name=7
ChainResidueDetails
ATRP229-LEU249
BTRP229-LEU249

site_idSWS_FT_FI10
Number of Residues18
DetailsTRANSMEM: Helical; Name=8
ChainResidueDetails
ALEU258-SER267
BLEU258-SER267

site_idSWS_FT_FI11
Number of Residues42
DetailsTRANSMEM: Helical; Name=9
ChainResidueDetails
ALEU275-LEU296
BLEU275-LEU296

site_idSWS_FT_FI12
Number of Residues38
DetailsTRANSMEM: Helical; Name=10
ChainResidueDetails
AILE305-ALA324
BILE305-ALA324

222415

PDB entries from 2024-07-10

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