4R8D
Crystal structure of Rv1600 encoded aminotransferase in complex with PLP-MES from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000105 | biological_process | L-histidine biosynthetic process |
| A | 0004400 | molecular_function | histidinol-phosphate transaminase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0000105 | biological_process | L-histidine biosynthetic process |
| B | 0004400 | molecular_function | histidinol-phosphate transaminase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP A 401 |
| Chain | Residue |
| A | GLY101 |
| A | SER231 |
| A | LYS232 |
| A | ARG240 |
| A | MES402 |
| A | HOH581 |
| B | TYR67 |
| A | SER102 |
| A | ASN103 |
| A | TYR127 |
| A | ASN176 |
| A | ASP201 |
| A | ALA203 |
| A | TYR204 |
| A | THR229 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MES A 402 |
| Chain | Residue |
| A | TYR25 |
| A | ASN37 |
| A | THR38 |
| A | ASN39 |
| A | ASN103 |
| A | TYR127 |
| A | MET129 |
| A | ASN176 |
| A | ARG337 |
| A | ARG346 |
| A | PLP401 |
| A | SO4403 |
| A | HOH601 |
| B | TYR67 |
| B | PRO260 |
| B | TYR261 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | TYR25 |
| A | GLY26 |
| A | ALA27 |
| A | ARG337 |
| A | MES402 |
| B | ARG70 |
| B | TYR261 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 404 |
| Chain | Residue |
| A | ALA17 |
| A | GLU59 |
| A | HOH551 |
| A | HOH613 |
| B | ARG118 |
| B | HOH555 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 405 |
| Chain | Residue |
| A | ARG118 |
| A | HOH574 |
| B | ALA17 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLP B 401 |
| Chain | Residue |
| A | TYR67 |
| B | GLY101 |
| B | SER102 |
| B | ASN103 |
| B | TYR127 |
| B | ASN176 |
| B | ASP201 |
| B | ALA203 |
| B | TYR204 |
| B | THR229 |
| B | SER231 |
| B | LYS232 |
| B | ARG240 |
| B | HOH592 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MES B 402 |
| Chain | Residue |
| A | TYR67 |
| B | TYR25 |
| B | ASN37 |
| B | THR38 |
| B | ASN39 |
| B | ASN103 |
| B | TYR127 |
| B | MET129 |
| B | ASN176 |
| B | ARG337 |
| B | ARG346 |
| B | SO4403 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 403 |
| Chain | Residue |
| A | ARG70 |
| A | TYR261 |
| B | TYR25 |
| B | GLY26 |
| B | ALA27 |
| B | ARG337 |
| B | MES402 |
Functional Information from PROSITE/UniProt
| site_id | PS00599 |
| Number of Residues | 10 |
| Details | AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TMSKAFAFAG |
| Chain | Residue | Details |
| A | THR229-GLY238 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26738801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R8D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
