4R7A
Crystal Structure of RBBP4 bound to PHF6 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000118 | cellular_component | histone deacetylase complex |
| B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| B | 0000781 | cellular_component | chromosome, telomeric region |
| B | 0000785 | cellular_component | chromatin |
| B | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0006260 | biological_process | DNA replication |
| B | 0006281 | biological_process | DNA repair |
| B | 0006325 | biological_process | chromatin organization |
| B | 0006334 | biological_process | nucleosome assembly |
| B | 0006335 | biological_process | DNA replication-dependent chromatin assembly |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006974 | biological_process | DNA damage response |
| B | 0007420 | biological_process | brain development |
| B | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0016581 | cellular_component | NuRD complex |
| B | 0016589 | cellular_component | NURF complex |
| B | 0030336 | biological_process | negative regulation of cell migration |
| B | 0030512 | biological_process | negative regulation of transforming growth factor beta receptor signaling pathway |
| B | 0031492 | molecular_function | nucleosomal DNA binding |
| B | 0031507 | biological_process | heterochromatin formation |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0033186 | cellular_component | CAF-1 complex |
| B | 0035098 | cellular_component | ESC/E(Z) complex |
| B | 0042393 | molecular_function | histone binding |
| B | 0042659 | biological_process | regulation of cell fate specification |
| B | 0042826 | molecular_function | histone deacetylase binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0070822 | cellular_component | Sin3-type complex |
| B | 1902455 | biological_process | negative regulation of stem cell population maintenance |
| B | 1902459 | biological_process | positive regulation of stem cell population maintenance |
| B | 2000736 | biological_process | regulation of stem cell differentiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 501 |
| Chain | Residue |
| B | SER259 |
| B | ASN261 |
| B | LYS264 |
| B | SER266 |
| B | ASN407 |
| B | HOH649 |
| B | HOH724 |
| B | HOH768 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI |
| Chain | Residue | Details |
| B | LEU193-ILE207 | |
| B | LEU289-LEU303 | |
| B | LEU333-LEU347 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 49 |
| Details | Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 47 |
| Details | Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q60972","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
