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4R7A

Crystal Structure of RBBP4 bound to PHF6 peptide

Functional Information from GO Data
ChainGOidnamespacecontents
B0000118cellular_componenthistone deacetylase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005829cellular_componentcytosol
B0006260biological_processDNA replication
B0006325biological_processchromatin organization
B0006334biological_processnucleosome assembly
B0006335biological_processDNA replication-dependent chromatin assembly
B0006338biological_processchromatin remodeling
B0006355biological_processregulation of DNA-templated transcription
B0007420biological_processbrain development
B0008094molecular_functionATP-dependent activity, acting on DNA
B0008285biological_processnegative regulation of cell population proliferation
B0016581cellular_componentNuRD complex
B0016589cellular_componentNURF complex
B0030336biological_processnegative regulation of cell migration
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0031492molecular_functionnucleosomal DNA binding
B0032991cellular_componentprotein-containing complex
B0033186cellular_componentCAF-1 complex
B0035098cellular_componentESC/E(Z) complex
B0042393molecular_functionhistone binding
B0042659biological_processregulation of cell fate specification
B0042826molecular_functionhistone deacetylase binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0070822cellular_componentSin3-type complex
B1902455biological_processnegative regulation of stem cell population maintenance
B1902459biological_processpositive regulation of stem cell population maintenance
B1904949cellular_componentATPase complex
B2000736biological_processregulation of stem cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 501
ChainResidue
BSER259
BASN261
BLYS264
BSER266
BASN407
BHOH649
BHOH724
BHOH768

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI
ChainResidueDetails
BLEU193-ILE207
BLEU289-LEU303
BLEU333-LEU347

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
BALA2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS4

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER110

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q60972
ChainResidueDetails
BLYS160

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER355

site_idSWS_FT_FI6
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
BLYS4

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS160

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PDB entries from 2024-07-24

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