4R5Z
Crystal structure of Rv3772 encoded aminotransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000105 | biological_process | L-histidine biosynthetic process |
| A | 0004400 | molecular_function | histidinol-phosphate transaminase activity |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0008793 | molecular_function | aromatic-amino-acid transaminase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0080130 | molecular_function | L-phenylalanine-2-oxoglutarate transaminase activity |
| B | 0000105 | biological_process | L-histidine biosynthetic process |
| B | 0004400 | molecular_function | histidinol-phosphate transaminase activity |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0008793 | molecular_function | aromatic-amino-acid transaminase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0080130 | molecular_function | L-phenylalanine-2-oxoglutarate transaminase activity |
| C | 0000105 | biological_process | L-histidine biosynthetic process |
| C | 0004400 | molecular_function | histidinol-phosphate transaminase activity |
| C | 0008483 | molecular_function | transaminase activity |
| C | 0008793 | molecular_function | aromatic-amino-acid transaminase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0080130 | molecular_function | L-phenylalanine-2-oxoglutarate transaminase activity |
| D | 0000105 | biological_process | L-histidine biosynthetic process |
| D | 0004400 | molecular_function | histidinol-phosphate transaminase activity |
| D | 0008483 | molecular_function | transaminase activity |
| D | 0008793 | molecular_function | aromatic-amino-acid transaminase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0080130 | molecular_function | L-phenylalanine-2-oxoglutarate transaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SIN A 401 |
| Chain | Residue |
| A | TYR15 |
| B | TYR54 |
| B | PHE246 |
| A | PRO17 |
| A | GLY18 |
| A | SER29 |
| A | ASN157 |
| A | ARG322 |
| A | ARG330 |
| A | PMP402 |
| A | HOH573 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PMP A 402 |
| Chain | Residue |
| A | GLY84 |
| A | SER85 |
| A | VAL86 |
| A | PHE110 |
| A | CYS153 |
| A | ASN157 |
| A | ASP184 |
| A | ALA186 |
| A | TYR187 |
| A | THR214 |
| A | SER216 |
| A | LYS217 |
| A | ARG225 |
| A | SIN401 |
| B | TYR54 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 403 |
| Chain | Residue |
| A | VAL14 |
| A | TYR15 |
| A | LEU112 |
| A | PRO115 |
| A | GLN116 |
| A | HOH514 |
| A | HOH851 |
| B | LYS241 |
| B | TYR243 |
| B | PRO245 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 404 |
| Chain | Residue |
| A | ARG108 |
| A | LEU129 |
| A | HIS132 |
| A | TRP300 |
| A | HOH584 |
| A | HOH664 |
| A | HOH734 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 405 |
| Chain | Residue |
| A | ASP73 |
| A | PHE74 |
| A | HIS78 |
| A | ARG204 |
| A | HIS232 |
| A | HOH784 |
| A | HOH797 |
| A | HOH809 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 406 |
| Chain | Residue |
| A | ASP49 |
| A | ASN52 |
| A | HOH610 |
| A | HOH677 |
| B | VAL33 |
| B | HOH743 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 407 |
| Chain | Residue |
| A | ASP198 |
| A | HOH593 |
| A | HOH769 |
| A | HOH804 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 408 |
| Chain | Residue |
| A | PHE289 |
| A | THR290 |
| A | PRO302 |
| A | LEU303 |
| A | ARG306 |
| A | HOH815 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EPE A 409 |
| Chain | Residue |
| A | ILE191 |
| A | ARG192 |
| A | ASP193 |
| A | GLY194 |
| A | MET195 |
| A | ARG196 |
| A | ASP271 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SIN B 401 |
| Chain | Residue |
| A | TYR54 |
| A | PHE246 |
| B | TYR15 |
| B | PRO17 |
| B | GLY18 |
| B | SER29 |
| B | ASN157 |
| B | ARG322 |
| B | ARG330 |
| B | PMP402 |
| B | HOH554 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PMP B 402 |
| Chain | Residue |
| A | TYR54 |
| B | GLY84 |
| B | SER85 |
| B | VAL86 |
| B | PHE110 |
| B | CYS153 |
| B | ASN157 |
| B | ASP184 |
| B | TYR187 |
| B | THR214 |
| B | SER216 |
| B | LYS217 |
| B | ARG225 |
| B | SIN401 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 403 |
| Chain | Residue |
| A | LYS241 |
| A | PRO245 |
| A | HOH545 |
| A | HOH562 |
| B | VAL14 |
| B | TYR15 |
| B | LEU112 |
| B | PRO115 |
| B | GLN116 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 404 |
| Chain | Residue |
| B | ARG108 |
| B | LEU129 |
| B | HIS132 |
| B | TRP300 |
| B | HOH596 |
| B | HOH798 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 405 |
| Chain | Residue |
| B | ASP73 |
| B | PHE74 |
| B | HIS78 |
| B | ARG204 |
| B | HIS232 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 406 |
| Chain | Residue |
| B | ASP73 |
| B | ASP198 |
| B | ARG204 |
| B | HOH631 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 407 |
| Chain | Residue |
| B | ALA286 |
| B | ALA287 |
| C | TYR137 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 408 |
| Chain | Residue |
| B | PHE289 |
| B | THR290 |
| B | PRO302 |
| B | LEU303 |
| B | ARG306 |
| B | ARG350 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EPE B 409 |
| Chain | Residue |
| B | ILE191 |
| B | ARG192 |
| B | ASP193 |
| B | GLY194 |
| B | MET195 |
| B | ARG196 |
| B | LEU267 |
| site_id | CC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SIN C 401 |
| Chain | Residue |
| C | TYR15 |
| C | PRO17 |
| C | GLY18 |
| C | ALA28 |
| C | SER29 |
| C | ASN157 |
| C | ARG322 |
| C | ARG330 |
| C | PMP402 |
| C | HOH655 |
| D | TYR54 |
| D | PHE246 |
| site_id | CC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PMP C 402 |
| Chain | Residue |
| C | GLY84 |
| C | SER85 |
| C | VAL86 |
| C | PHE110 |
| C | CYS153 |
| C | ASN157 |
| C | ASP184 |
| C | ALA186 |
| C | TYR187 |
| C | THR214 |
| C | SER216 |
| C | LYS217 |
| C | ARG225 |
| C | SIN401 |
| D | TYR54 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 403 |
| Chain | Residue |
| C | ASP73 |
| C | HIS78 |
| C | VAL203 |
| C | ARG204 |
| C | HIS232 |
| C | HOH688 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 404 |
| Chain | Residue |
| C | TYR15 |
| C | PRO115 |
| C | GLN116 |
| C | HOH563 |
| C | HOH564 |
| D | LYS241 |
| D | TYR243 |
| D | PRO245 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 405 |
| Chain | Residue |
| C | ARG108 |
| C | HIS132 |
| C | TRP300 |
| C | HOH533 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 406 |
| Chain | Residue |
| B | ASP340 |
| B | ARG344 |
| B | ARG347 |
| B | HOH502 |
| B | HOH738 |
| C | ASP166 |
| C | ARG170 |
| site_id | CC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EPE C 407 |
| Chain | Residue |
| C | ILE191 |
| C | ARG192 |
| C | ASP193 |
| C | GLY194 |
| C | MET195 |
| C | ARG196 |
| C | ASP271 |
| C | HOH674 |
| site_id | CC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SIN D 401 |
| Chain | Residue |
| C | TYR54 |
| C | PHE246 |
| D | TYR15 |
| D | PRO17 |
| D | GLY18 |
| D | SER29 |
| D | ASN157 |
| D | ARG322 |
| D | ARG330 |
| D | PMP402 |
| D | HOH552 |
| site_id | CC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PMP D 402 |
| Chain | Residue |
| C | TYR54 |
| D | GLY84 |
| D | SER85 |
| D | VAL86 |
| D | PHE110 |
| D | CYS153 |
| D | ASN157 |
| D | ASP184 |
| D | ALA186 |
| D | TYR187 |
| D | THR214 |
| D | SER216 |
| D | LYS217 |
| D | ARG225 |
| D | SIN401 |
| site_id | DC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 403 |
| Chain | Residue |
| C | LYS241 |
| C | PRO245 |
| C | HOH538 |
| D | TYR15 |
| D | LEU112 |
| D | PRO115 |
| D | GLN116 |
| D | HOH556 |
| site_id | DC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 404 |
| Chain | Residue |
| D | TRP107 |
| D | ARG108 |
| D | HIS132 |
| D | TRP300 |
| D | HOH681 |
| D | HOH717 |
| D | HOH726 |
| D | HOH740 |
| site_id | DC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 405 |
| Chain | Residue |
| D | ASP73 |
| D | PHE74 |
| D | HIS78 |
| D | VAL203 |
| D | ARG204 |
| D | HIS232 |
| D | HOH782 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 406 |
| Chain | Residue |
| A | GLU337 |
| A | HOH775 |
| D | PHE34 |
| D | ARG269 |
| D | HOH586 |
| D | HOH615 |
| site_id | DC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EPE D 407 |
| Chain | Residue |
| D | ILE191 |
| D | ARG192 |
| D | ASP193 |
| D | GLY194 |
| D | MET195 |
| D | ARG196 |
| D | LEU267 |
| D | ASP271 |
| D | HOH746 |
Functional Information from PROSITE/UniProt
| site_id | PS00599 |
| Number of Residues | 10 |
| Details | AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TFSKAYGLAG |
| Chain | Residue | Details |
| A | THR214-GLY223 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01513","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26738801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R2N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
