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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4R57

Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with acetyl-CoA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004145molecular_functiondiamine N-acetyltransferase activity
A0005737cellular_componentcytoplasm
A0006598biological_processpolyamine catabolic process
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
A0046203biological_processspermidine catabolic process
A0046208biological_processspermine catabolic process
A0046872molecular_functionmetal ion binding
B0000287molecular_functionmagnesium ion binding
B0004145molecular_functiondiamine N-acetyltransferase activity
B0005737cellular_componentcytoplasm
B0006598biological_processpolyamine catabolic process
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
B0046203biological_processspermidine catabolic process
B0046208biological_processspermine catabolic process
B0046872molecular_functionmetal ion binding
C0000287molecular_functionmagnesium ion binding
C0004145molecular_functiondiamine N-acetyltransferase activity
C0005737cellular_componentcytoplasm
C0006598biological_processpolyamine catabolic process
C0016740molecular_functiontransferase activity
C0016746molecular_functionacyltransferase activity
C0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
C0046203biological_processspermidine catabolic process
C0046208biological_processspermine catabolic process
C0046872molecular_functionmetal ion binding
D0000287molecular_functionmagnesium ion binding
D0004145molecular_functiondiamine N-acetyltransferase activity
D0005737cellular_componentcytoplasm
D0006598biological_processpolyamine catabolic process
D0016740molecular_functiontransferase activity
D0016746molecular_functionacyltransferase activity
D0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
D0046203biological_processspermidine catabolic process
D0046208biological_processspermine catabolic process
D0046872molecular_functionmetal ion binding
E0000287molecular_functionmagnesium ion binding
E0004145molecular_functiondiamine N-acetyltransferase activity
E0005737cellular_componentcytoplasm
E0006598biological_processpolyamine catabolic process
E0016740molecular_functiontransferase activity
E0016746molecular_functionacyltransferase activity
E0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
E0046203biological_processspermidine catabolic process
E0046208biological_processspermine catabolic process
E0046872molecular_functionmetal ion binding
F0000287molecular_functionmagnesium ion binding
F0004145molecular_functiondiamine N-acetyltransferase activity
F0005737cellular_componentcytoplasm
F0006598biological_processpolyamine catabolic process
F0016740molecular_functiontransferase activity
F0016746molecular_functionacyltransferase activity
F0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
F0046203biological_processspermidine catabolic process
F0046208biological_processspermine catabolic process
F0046872molecular_functionmetal ion binding
G0000287molecular_functionmagnesium ion binding
G0004145molecular_functiondiamine N-acetyltransferase activity
G0005737cellular_componentcytoplasm
G0006598biological_processpolyamine catabolic process
G0016740molecular_functiontransferase activity
G0016746molecular_functionacyltransferase activity
G0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
G0046203biological_processspermidine catabolic process
G0046208biological_processspermine catabolic process
G0046872molecular_functionmetal ion binding
H0000287molecular_functionmagnesium ion binding
H0004145molecular_functiondiamine N-acetyltransferase activity
H0005737cellular_componentcytoplasm
H0006598biological_processpolyamine catabolic process
H0016740molecular_functiontransferase activity
H0016746molecular_functionacyltransferase activity
H0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
H0046203biological_processspermidine catabolic process
H0046208biological_processspermine catabolic process
H0046872molecular_functionmetal ion binding
I0000287molecular_functionmagnesium ion binding
I0004145molecular_functiondiamine N-acetyltransferase activity
I0005737cellular_componentcytoplasm
I0006598biological_processpolyamine catabolic process
I0016740molecular_functiontransferase activity
I0016746molecular_functionacyltransferase activity
I0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
I0046203biological_processspermidine catabolic process
I0046208biological_processspermine catabolic process
I0046872molecular_functionmetal ion binding
J0000287molecular_functionmagnesium ion binding
J0004145molecular_functiondiamine N-acetyltransferase activity
J0005737cellular_componentcytoplasm
J0006598biological_processpolyamine catabolic process
J0016740molecular_functiontransferase activity
J0016746molecular_functionacyltransferase activity
J0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
J0046203biological_processspermidine catabolic process
J0046208biological_processspermine catabolic process
J0046872molecular_functionmetal ion binding
K0000287molecular_functionmagnesium ion binding
K0004145molecular_functiondiamine N-acetyltransferase activity
K0005737cellular_componentcytoplasm
K0006598biological_processpolyamine catabolic process
K0016740molecular_functiontransferase activity
K0016746molecular_functionacyltransferase activity
K0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
K0046203biological_processspermidine catabolic process
K0046208biological_processspermine catabolic process
K0046872molecular_functionmetal ion binding
L0000287molecular_functionmagnesium ion binding
L0004145molecular_functiondiamine N-acetyltransferase activity
L0005737cellular_componentcytoplasm
L0006598biological_processpolyamine catabolic process
L0016740molecular_functiontransferase activity
L0016746molecular_functionacyltransferase activity
L0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
L0046203biological_processspermidine catabolic process
L0046208biological_processspermine catabolic process
L0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ACO A 201
ChainResidue
ATYR30
AGLY97
APHE98
AALA99
AARG100
AHIS122
AASN127
ALYS129
ALEU133
ATYR134
ATRP31
AGLN86
AILE87
AILE88
AILE89
AGLN94
AGLY95
ALYS96
site_idAC2
Number of Residues19
DetailsBINDING SITE FOR RESIDUE ACO B 201
ChainResidue
BTYR30
BPHE85
BGLN86
BILE87
BILE89
BGLN94
BGLY95
BLYS96
BGLY97
BPHE98
BALA99
BARG100
BLEU121
BHIS122
BHIS132
BLEU133
BTYR134
BGLU136
BHOH305
site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PG4 B 202
ChainResidue
BILE50
BHIS51
BASN53
BARG56
DGLU34
DTYR36
DGLU41
site_idAC4
Number of Residues19
DetailsBINDING SITE FOR RESIDUE ACO C 201
ChainResidue
CTYR30
CTRP31
CPHE85
CGLN86
CILE87
CILE88
CILE89
CGLN94
CGLY95
CLYS96
CGLY97
CPHE98
CALA99
CLEU121
CHIS122
CVAL123
CLYS129
CTYR134
CGLU136
site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PEG C 202
ChainResidue
CGLU34
CTYR36
CGLU37
CGLU41
CLEU45
site_idAC6
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ACO D 201
ChainResidue
DTYR30
DTRP31
DPHE85
DGLN86
DILE87
DILE89
DGLN94
DGLY95
DLYS96
DGLY97
DPHE98
DALA99
DARG100
DHIS122
DHIS132
DTYR134
DGLU136
DHOH315
site_idAC7
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ACO E 201
ChainResidue
EHIS122
ELYS129
ELEU133
ETYR134
EGLU136
ETYR30
ETRP31
EPHE85
EGLN86
EILE87
EILE88
EILE89
EGLN94
EGLY95
EGLY97
EPHE98
EALA99
EARG100
site_idAC8
Number of Residues19
DetailsBINDING SITE FOR RESIDUE ACO F 201
ChainResidue
FTYR30
FTRP31
FPHE85
FGLN86
FILE87
FILE88
FILE89
FGLN94
FGLY95
FLYS96
FGLY97
FPHE98
FALA99
FARG100
FHIS122
FLYS129
FHIS132
FLEU133
FTYR134
site_idAC9
Number of Residues22
DetailsBINDING SITE FOR RESIDUE ACO G 201
ChainResidue
GTYR30
GTRP31
GPHE85
GGLN86
GILE87
GILE88
GILE89
GGLN94
GGLY95
GLYS96
GGLY97
GPHE98
GALA99
GARG100
GLEU121
GHIS122
GLYS129
GHIS132
GLEU133
GTYR134
GHOH320
IASN170
site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PEG G 202
ChainResidue
EASN53
GGLU33
GGLU34
GTYR36
GGLU41
site_idBC2
Number of Residues24
DetailsBINDING SITE FOR RESIDUE ACO H 201
ChainResidue
HTYR30
HTRP31
HPHE85
HGLN86
HILE87
HILE88
HILE89
HGLN94
HGLY95
HLYS96
HGLY97
HPHE98
HALA99
HARG100
HLEU121
HHIS122
HVAL123
HASN127
HPRO128
HLYS129
HHIS132
HTYR134
HGLU136
HHOH302
site_idBC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PEG H 202
ChainResidue
FARG56
HTYR36
HGLU41
site_idBC4
Number of Residues21
DetailsBINDING SITE FOR RESIDUE ACO I 201
ChainResidue
ITYR30
ITRP31
IPHE85
IGLN86
IILE87
IILE88
IILE89
IGLN94
IGLY95
ILYS96
IGLY97
IPHE98
IALA99
IARG100
ILEU121
IHIS122
IASN127
ILYS129
ILEU133
ITYR134
IHOH308
site_idBC5
Number of Residues20
DetailsBINDING SITE FOR RESIDUE ACO J 201
ChainResidue
JTYR30
JTRP31
JGLN86
JILE87
JILE89
JGLN94
JGLY95
JLYS96
JGLY97
JPHE98
JALA99
JARG100
JHIS122
JVAL123
JLYS129
JHIS132
JTYR134
JGLU136
JHOH310
JHOH325
site_idBC6
Number of Residues20
DetailsBINDING SITE FOR RESIDUE ACO K 201
ChainResidue
KILE27
KTYR30
KGLN86
KILE87
KILE88
KILE89
KGLN94
KGLY95
KLYS96
KGLY97
KPHE98
KALA99
KARG100
KHIS122
KASN127
KLYS129
KHIS132
KLEU133
KTYR134
KGLU136
site_idBC7
Number of Residues20
DetailsBINDING SITE FOR RESIDUE ACO L 201
ChainResidue
LTYR30
LTRP31
LPHE85
LGLN86
LILE87
LILE88
LILE89
LGLN94
LGLY95
LLYS96
LGLY97
LPHE98
LALA99
LARG100
LLEU121
LHIS122
LASN127
LTYR134
LGLU136
LHOH313
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1884
DetailsDomain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P0A951","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2013","submissionDatabase":"PDB data bank","title":"Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with polyamine.","authors":["Filippova E.V.","Minasov G.","Shuvalova L.","Kiryukhina O.","Kuhn M.L.","Anderson W.F."]}},{"source":"PDB","id":"4MJ8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MI4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R87","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R87","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26410587","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CNP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues96
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4R87","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues108
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R57","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsSite: {"description":"Could be important for selectivity toward long polyamines","evidences":[{"source":"PubMed","id":"25623305","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2025-07-09

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