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4R3Z

Crystal structure of human ArgRS-GlnRS-AIMP1 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0001525biological_processangiogenesis
A0001937biological_processnegative regulation of endothelial cell proliferation
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006412biological_processtranslation
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0007267biological_processcell-cell signaling
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0017101cellular_componentaminoacyl-tRNA synthetase multienzyme complex
A0042803molecular_functionprotein homodimerization activity
A0048514biological_processblood vessel morphogenesis
A0050900biological_processleukocyte migration
A0051020molecular_functionGTPase binding
A0051607biological_processdefense response to virus
A0070094biological_processpositive regulation of glucagon secretion
B0000049molecular_functiontRNA binding
B0000166molecular_functionnucleotide binding
B0004812molecular_functionaminoacyl-tRNA ligase activity
B0004814molecular_functionarginine-tRNA ligase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006412biological_processtranslation
B0006418biological_processtRNA aminoacylation for protein translation
B0006420biological_processarginyl-tRNA aminoacylation
B0016020cellular_componentmembrane
B0017101cellular_componentaminoacyl-tRNA synthetase multienzyme complex
B0034618molecular_functionarginine binding
B0045296molecular_functioncadherin binding
B0070062cellular_componentextracellular exosome
C0000166molecular_functionnucleotide binding
C0004812molecular_functionaminoacyl-tRNA ligase activity
C0004819molecular_functionglutamine-tRNA ligase activity
C0004860molecular_functionprotein kinase inhibitor activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0006412biological_processtranslation
C0006418biological_processtRNA aminoacylation for protein translation
C0006425biological_processglutaminyl-tRNA aminoacylation
C0006469biological_processnegative regulation of protein kinase activity
C0007420biological_processbrain development
C0017101cellular_componentaminoacyl-tRNA synthetase multienzyme complex
C0019901molecular_functionprotein kinase binding
C0032873biological_processnegative regulation of stress-activated MAPK cascade
C0032991cellular_componentprotein-containing complex
C0043039biological_processtRNA aminoacylation
C0045892biological_processnegative regulation of DNA-templated transcription
C2001234biological_processnegative regulation of apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00178
Number of Residues12
DetailsAA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PniAKeMHVGHL
ChainResidueDetails
BPRO201-LEU212
CPRO270-ALA281

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00962
ChainResidueDetails
CGLU271
CHIS277
CASP303
CTYR438
CTHR457
CARG486
CVAL494

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.5, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
CALA2

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
CSER70

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS309

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER495

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PDB entries from 2024-07-17

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