4R2W
X-ray structure of uridine phosphorylase from Shewanella oneidensis MR-1 in complex with uridine at 1.6 A resolution
Replaces: 4HERFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0044206 | biological_process | UMP salvage |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0044206 | biological_process | UMP salvage |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0009166 | biological_process | nucleotide catabolic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0044206 | biological_process | UMP salvage |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0009166 | biological_process | nucleotide catabolic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0044206 | biological_process | UMP salvage |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009164 | biological_process | nucleoside catabolic process |
| E | 0009166 | biological_process | nucleotide catabolic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0044206 | biological_process | UMP salvage |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009164 | biological_process | nucleoside catabolic process |
| F | 0009166 | biological_process | nucleotide catabolic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0044206 | biological_process | UMP salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | ARG175 |
| C | ARG175 |
| E | ARG175 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | GOL303 |
| B | ARG45 |
| A | GLY23 |
| A | ARG27 |
| A | ARG88 |
| A | VAL89 |
| A | GLY90 |
| A | THR91 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 303 |
| Chain | Residue |
| A | ARG88 |
| A | THR91 |
| A | GLU193 |
| A | MET194 |
| A | GLU195 |
| A | SO4302 |
| A | HOH423 |
| A | HOH460 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| A | ARG45 |
| B | GLY23 |
| B | ARG27 |
| B | ARG88 |
| B | VAL89 |
| B | GLY90 |
| B | THR91 |
| B | HOH501 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 302 |
| Chain | Residue |
| B | ASN130 |
| B | ALA204 |
| B | HOH513 |
| B | HOH555 |
| B | HOH573 |
| B | HOH577 |
| E | HOH435 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 301 |
| Chain | Residue |
| C | GLY23 |
| C | ARG27 |
| C | ARG88 |
| C | VAL89 |
| C | GLY90 |
| C | THR91 |
| C | GOL302 |
| D | ARG45 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL C 302 |
| Chain | Residue |
| C | ILE66 |
| C | ARG88 |
| C | THR91 |
| C | GLU193 |
| C | MET194 |
| C | GLU195 |
| C | SO4301 |
| C | HOH459 |
| C | HOH513 |
| C | HOH514 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 301 |
| Chain | Residue |
| C | ARG45 |
| D | GLY23 |
| D | ARG27 |
| D | ARG88 |
| D | VAL89 |
| D | GLY90 |
| D | THR91 |
| D | GOL302 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL D 302 |
| Chain | Residue |
| C | ARG45 |
| D | ILE66 |
| D | ARG88 |
| D | THR91 |
| D | GLU193 |
| D | MET194 |
| D | GLU195 |
| D | SO4301 |
| D | HOH402 |
| D | HOH494 |
| D | HOH506 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 303 |
| Chain | Residue |
| A | HOH496 |
| D | ASN130 |
| D | ALA204 |
| D | HOH401 |
| D | HOH416 |
| D | HOH430 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 301 |
| Chain | Residue |
| E | GLY23 |
| E | ARG88 |
| E | THR91 |
| E | HOH476 |
| F | ARG45 |
| site_id | BC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE URI F 301 |
| Chain | Residue |
| E | HIS5 |
| F | ILE66 |
| F | ARG88 |
| F | THR91 |
| F | THR92 |
| F | GLY93 |
| F | PHE159 |
| F | GLN163 |
| F | ARG165 |
| F | TYR192 |
| F | GLU193 |
| F | MET194 |
| F | GLU195 |
| F | SO4303 |
| F | HOH452 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 F 302 |
| Chain | Residue |
| F | ARG175 |
| B | ARG175 |
| D | ARG175 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 F 303 |
| Chain | Residue |
| E | ARG45 |
| F | GLY23 |
| F | ARG27 |
| F | ARG88 |
| F | VAL89 |
| F | GLY90 |
| F | THR91 |
| F | URI301 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL F 304 |
| Chain | Residue |
| C | HOH462 |
| C | HOH516 |
| F | ASN130 |
| F | ALA204 |
| F | HOH420 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER63-LEU78 |
