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4R2U

Crystal Structure of PPARgamma in complex with SR1664

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
D0003677molecular_functionDNA binding
D0004879molecular_functionnuclear receptor activity
D0005634cellular_componentnucleus
D0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE 3JX A 501
ChainResidue
APHE282
AILE341
ASER342
APHE363
AMET364
ALYS367
AHIS449
ALEU453
ALEU465
ATYR473
AHOH671
AGLY284
ACYS285
AGLN286
AARG288
ASER289
AHIS323
ATYR327
ALEU330

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 3JX D 501
ChainResidue
DHIS266
DILE281
DPHE282
DGLN286
DARG288
DSER289
DILE326
DTYR327
DLEU330
DILE341
DSER342
DMET364
DLYS367
DHIS449
DLEU453

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
AGLN286
AHIS323
AHIS449
ATYR473
DGLN286
DHIS323
DHIS449
DTYR473

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224
DLYS224

219140

PDB entries from 2024-05-01

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