4R2G

Crystal Structure of PGT124 Fab bound to HIV-1 JRCSF gp120 core and to CD4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0019031	cellular_component	viral envelope
B	0007155	biological_process	cell adhesion
B	0016020	cellular_component	membrane
C	0002250	biological_process	adaptive immune response
C	0003823	molecular_function	antigen binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0016064	biological_process	immunoglobulin mediated immune response
C	0019814	cellular_component	immunoglobulin complex
C	0050853	biological_process	B cell receptor signaling pathway
C	0070062	cellular_component	extracellular exosome
C	0071735	cellular_component	IgG immunoglobulin complex
C	0071738	cellular_component	IgD immunoglobulin complex
C	0071742	cellular_component	IgE immunoglobulin complex
C	0071745	cellular_component	IgA immunoglobulin complex
C	0071753	cellular_component	IgM immunoglobulin complex
C	0072562	cellular_component	blood microparticle
E	0019031	cellular_component	viral envelope
F	0007155	biological_process	cell adhesion
F	0016020	cellular_component	membrane
H	0007155	biological_process	cell adhesion
H	0016020	cellular_component	membrane
I	0002250	biological_process	adaptive immune response
I	0003823	molecular_function	antigen binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005886	cellular_component	plasma membrane
I	0016064	biological_process	immunoglobulin mediated immune response
I	0019814	cellular_component	immunoglobulin complex
I	0050853	biological_process	B cell receptor signaling pathway
I	0070062	cellular_component	extracellular exosome
I	0071735	cellular_component	IgG immunoglobulin complex
I	0071738	cellular_component	IgD immunoglobulin complex
I	0071742	cellular_component	IgE immunoglobulin complex
I	0071745	cellular_component	IgA immunoglobulin complex
I	0071753	cellular_component	IgM immunoglobulin complex
I	0072562	cellular_component	blood microparticle
K	0019031	cellular_component	viral envelope
L	0007155	biological_process	cell adhesion
L	0016020	cellular_component	membrane
M	0002250	biological_process	adaptive immune response
M	0003823	molecular_function	antigen binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005886	cellular_component	plasma membrane
M	0016064	biological_process	immunoglobulin mediated immune response
M	0019814	cellular_component	immunoglobulin complex
M	0050853	biological_process	B cell receptor signaling pathway
M	0070062	cellular_component	extracellular exosome
M	0071735	cellular_component	IgG immunoglobulin complex
M	0071738	cellular_component	IgD immunoglobulin complex
M	0071742	cellular_component	IgE immunoglobulin complex
M	0071745	cellular_component	IgA immunoglobulin complex
M	0071753	cellular_component	IgM immunoglobulin complex
M	0072562	cellular_component	blood microparticle
O	0019031	cellular_component	viral envelope
P	0002250	biological_process	adaptive immune response
P	0003823	molecular_function	antigen binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005886	cellular_component	plasma membrane
P	0016064	biological_process	immunoglobulin mediated immune response
P	0019814	cellular_component	immunoglobulin complex
P	0050853	biological_process	B cell receptor signaling pathway
P	0070062	cellular_component	extracellular exosome
P	0071735	cellular_component	IgG immunoglobulin complex
P	0071738	cellular_component	IgD immunoglobulin complex
P	0071742	cellular_component	IgE immunoglobulin complex
P	0071745	cellular_component	IgA immunoglobulin complex
P	0071753	cellular_component	IgM immunoglobulin complex
P	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
Q	TYR212-HIS218
P	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:826475

Chain	Residue	Details
Q	GLN1
E	ASN356
E	ASN386
E	ASN392
E	ASN396
E	ASN411
E	ASN448
E	ASN461
O	ASN230
O	ASN241
O	ASN262
D	GLN1
O	ASN276
O	ASN289
O	ASN295
O	ASN301
O	ASN332
O	ASN339
O	ASN356
O	ASN386
O	ASN392
O	ASN396
J	GLN1
O	ASN411
O	ASN448
O	ASN461
A	ASN230
A	ASN241
A	ASN262
A	ASN276
A	ASN289
A	ASN295
A	ASN301
N	GLN1
A	ASN332
A	ASN339
A	ASN356
A	ASN386
A	ASN392
A	ASN396
A	ASN411
A	ASN448
A	ASN461
K	ASN230
E	ASN289
K	ASN241
K	ASN262
K	ASN276
K	ASN289
K	ASN295
K	ASN301
K	ASN332
K	ASN339
K	ASN356
K	ASN386
E	ASN295
K	ASN392
K	ASN396
K	ASN411
K	ASN448
K	ASN461
E	ASN301
E	ASN332
E	ASN339

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
Q	THR73
D	THR73
J	THR73
N	THR73

---