4R2G

Crystal Structure of PGT124 Fab bound to HIV-1 JRCSF gp120 core and to CD4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0019031	cellular_component	viral envelope
B	0007155	biological_process	cell adhesion
B	0016020	cellular_component	membrane
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0003823	molecular_function	antigen binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0016020	cellular_component	membrane
C	0016064	biological_process	immunoglobulin mediated immune response
C	0019814	cellular_component	immunoglobulin complex
C	0050853	biological_process	B cell receptor signaling pathway
C	0070062	cellular_component	extracellular exosome
C	0071735	cellular_component	IgG immunoglobulin complex
C	0071738	cellular_component	IgD immunoglobulin complex
C	0071742	cellular_component	IgE immunoglobulin complex
C	0071745	cellular_component	IgA immunoglobulin complex
C	0071753	cellular_component	IgM immunoglobulin complex
C	0072562	cellular_component	blood microparticle
E	0019031	cellular_component	viral envelope
F	0007155	biological_process	cell adhesion
F	0016020	cellular_component	membrane
H	0007155	biological_process	cell adhesion
H	0016020	cellular_component	membrane
I	0002250	biological_process	adaptive immune response
I	0002376	biological_process	immune system process
I	0003823	molecular_function	antigen binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005886	cellular_component	plasma membrane
I	0016020	cellular_component	membrane
I	0016064	biological_process	immunoglobulin mediated immune response
I	0019814	cellular_component	immunoglobulin complex
I	0050853	biological_process	B cell receptor signaling pathway
I	0070062	cellular_component	extracellular exosome
I	0071735	cellular_component	IgG immunoglobulin complex
I	0071738	cellular_component	IgD immunoglobulin complex
I	0071742	cellular_component	IgE immunoglobulin complex
I	0071745	cellular_component	IgA immunoglobulin complex
I	0071753	cellular_component	IgM immunoglobulin complex
I	0072562	cellular_component	blood microparticle
K	0019031	cellular_component	viral envelope
L	0007155	biological_process	cell adhesion
L	0016020	cellular_component	membrane
M	0002250	biological_process	adaptive immune response
M	0002376	biological_process	immune system process
M	0003823	molecular_function	antigen binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005886	cellular_component	plasma membrane
M	0016020	cellular_component	membrane
M	0016064	biological_process	immunoglobulin mediated immune response
M	0019814	cellular_component	immunoglobulin complex
M	0050853	biological_process	B cell receptor signaling pathway
M	0070062	cellular_component	extracellular exosome
M	0071735	cellular_component	IgG immunoglobulin complex
M	0071738	cellular_component	IgD immunoglobulin complex
M	0071742	cellular_component	IgE immunoglobulin complex
M	0071745	cellular_component	IgA immunoglobulin complex
M	0071753	cellular_component	IgM immunoglobulin complex
M	0072562	cellular_component	blood microparticle
O	0019031	cellular_component	viral envelope
P	0002250	biological_process	adaptive immune response
P	0002376	biological_process	immune system process
P	0003823	molecular_function	antigen binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005886	cellular_component	plasma membrane
P	0016020	cellular_component	membrane
P	0016064	biological_process	immunoglobulin mediated immune response
P	0019814	cellular_component	immunoglobulin complex
P	0050853	biological_process	B cell receptor signaling pathway
P	0070062	cellular_component	extracellular exosome
P	0071735	cellular_component	IgG immunoglobulin complex
P	0071738	cellular_component	IgD immunoglobulin complex
P	0071742	cellular_component	IgE immunoglobulin complex
P	0071745	cellular_component	IgA immunoglobulin complex
P	0071753	cellular_component	IgM immunoglobulin complex
P	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
Q	TYR212-HIS218
P	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Region: {"description":"CD4-binding loop","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	116
Details	Region: {"description":"V4","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	Region: {"description":"V5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	36
Details	Region: {"description":"V5","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	68
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	297
Details	Domain: {"description":"Ig-like V-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	376
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"826475","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---