4QYI
1.95 Angstrom resolution crystal structure of a hypoxanthine-guanine phosphoribosyltransferase (hpt-2) from Bacillus anthracis str. 'Ames Ancestor' with HEPES molecule in the active site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006178 | biological_process | guanine salvage |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006178 | biological_process | guanine salvage |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0006178 | biological_process | guanine salvage |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0046100 | biological_process | hypoxanthine metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0006178 | biological_process | guanine salvage |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0046100 | biological_process | hypoxanthine metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006166 | biological_process | purine ribonucleoside salvage |
| E | 0006178 | biological_process | guanine salvage |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016757 | molecular_function | glycosyltransferase activity |
| E | 0032263 | biological_process | GMP salvage |
| E | 0032264 | biological_process | IMP salvage |
| E | 0046100 | biological_process | hypoxanthine metabolic process |
| E | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 201 |
| Chain | Residue |
| A | GLU98 |
| A | ASP99 |
| A | PO4202 |
| A | HOH308 |
| A | HOH314 |
| A | HOH321 |
| A | HOH326 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 202 |
| Chain | Residue |
| A | GLY43 |
| A | ASP158 |
| A | ARG164 |
| A | MG201 |
| A | HOH314 |
| A | HOH317 |
| A | HOH321 |
| A | LEU41 |
| A | LYS42 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 203 |
| Chain | Residue |
| A | ILE101 |
| A | ASP102 |
| A | SER103 |
| A | GLY104 |
| A | LEU105 |
| A | THR106 |
| A | LEU107 |
| A | HOH331 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 201 |
| Chain | Residue |
| B | GLU98 |
| B | ASP99 |
| B | HOH335 |
| B | HOH355 |
| B | HOH365 |
| B | HOH383 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 202 |
| Chain | Residue |
| B | ASP158 |
| B | PO4203 |
| B | EPE204 |
| B | HOH337 |
| B | HOH401 |
| B | HOH402 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PO4 B 203 |
| Chain | Residue |
| B | LEU41 |
| B | LYS42 |
| B | GLY43 |
| B | ASP158 |
| B | ARG164 |
| B | MG202 |
| B | EPE204 |
| B | HOH333 |
| B | HOH335 |
| B | HOH336 |
| B | HOH355 |
| B | HOH385 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EPE B 204 |
| Chain | Residue |
| B | ILE101 |
| B | ASP102 |
| B | SER103 |
| B | GLY104 |
| B | LEU105 |
| B | THR106 |
| B | LEU107 |
| B | MG202 |
| B | PO4203 |
| B | HOH383 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 201 |
| Chain | Residue |
| C | GLU98 |
| C | ASP99 |
| C | HOH352 |
| C | HOH360 |
| C | HOH361 |
| C | HOH377 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 202 |
| Chain | Residue |
| C | ASP158 |
| C | PO4203 |
| C | HOH348 |
| C | HOH359 |
| site_id | BC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PO4 C 203 |
| Chain | Residue |
| C | LEU41 |
| C | LYS42 |
| C | GLY43 |
| C | ASP158 |
| C | ARG164 |
| C | MG202 |
| C | EPE204 |
| C | HOH347 |
| C | HOH360 |
| C | HOH376 |
| C | HOH377 |
| C | HOH386 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EPE C 204 |
| Chain | Residue |
| C | ILE101 |
| C | ASP102 |
| C | SER103 |
| C | GLY104 |
| C | THR106 |
| C | LEU107 |
| C | PO4203 |
| C | HOH352 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 201 |
| Chain | Residue |
| D | GLU98 |
| D | ASP99 |
| D | PO4202 |
| D | HOH302 |
| D | HOH316 |
| D | HOH319 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 202 |
| Chain | Residue |
| D | HOH316 |
| D | HOH318 |
| D | LYS42 |
| D | GLY43 |
| D | ASP158 |
| D | ARG164 |
| D | MG201 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 203 |
| Chain | Residue |
| D | ASP102 |
| D | SER103 |
| D | GLY104 |
| D | LEU105 |
| D | THR106 |
| D | LEU107 |
| D | HOH306 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG E 201 |
| Chain | Residue |
| E | GLU98 |
| E | ASP99 |
| E | HOH349 |
| E | HOH350 |
| E | HOH367 |
| E | HOH372 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG E 202 |
| Chain | Residue |
| E | HOH340 |
| E | HOH341 |
| E | HOH369 |
| E | HOH370 |
| E | HOH371 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG E 203 |
| Chain | Residue |
| E | ASP158 |
| E | PO4205 |
| E | EPE207 |
| E | HOH373 |
| E | HOH374 |
| E | HOH381 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL E 204 |
| Chain | Residue |
| E | GLU12 |
| E | ARG53 |
| E | HIS54 |
| E | HOH351 |
| E | HOH384 |
| site_id | CC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 E 205 |
| Chain | Residue |
| E | LYS42 |
| E | GLY43 |
| E | ASP158 |
| E | ARG164 |
| E | MG203 |
| E | EPE207 |
| E | HOH346 |
| E | HOH349 |
| E | HOH366 |
| E | HOH372 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 E 206 |
| Chain | Residue |
| E | ILE100 |
| E | ILE101 |
| E | ASP102 |
| E | SER103 |
| E | GLY104 |
| E | LEU105 |
| E | LEU107 |
| site_id | CC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EPE E 207 |
| Chain | Residue |
| E | ASP102 |
| E | GLY104 |
| E | THR106 |
| E | LEU107 |
| E | MG203 |
| E | PO4205 |
| E | HOH350 |
| E | HOH374 |
| E | HOH381 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VIVVEDIIDSGlT |
| Chain | Residue | Details |
| A | VAL94-THR106 | |
| B | VAL94-THR106 |
