4QXC
Crystal structure of histone demethylase KDM2A-H3K36ME2 with NOG
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE OGA A 600 |
| Chain | Residue |
| A | ASN142 |
| A | HOH720 |
| E | MLY36 |
| A | THR209 |
| A | HIS212 |
| A | ASP214 |
| A | TYR222 |
| A | LYS229 |
| A | HIS284 |
| A | VAL286 |
| A | NI601 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 601 |
| Chain | Residue |
| A | HIS212 |
| A | ASP214 |
| A | HIS284 |
| A | OGA600 |
| A | HOH854 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE OGA C 600 |
| Chain | Residue |
| C | ASN142 |
| C | LEU201 |
| C | THR209 |
| C | HIS212 |
| C | ASP214 |
| C | TYR222 |
| C | LYS229 |
| C | HIS284 |
| C | VAL286 |
| C | NI601 |
| C | HOH731 |
| C | HOH825 |
| F | MLY36 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI C 601 |
| Chain | Residue |
| C | HIS212 |
| C | ASP214 |
| C | HIS284 |
| C | OGA600 |
| C | HOH825 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 336 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"Q9Y2K7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"13678296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
