4QWW
Crystal structure of the Fab410-BfAChE complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001507 | biological_process | acetylcholine catabolic process in synaptic cleft |
| A | 0003990 | molecular_function | acetylcholinesterase activity |
| A | 0004104 | molecular_function | cholinesterase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006581 | biological_process | acetylcholine catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019695 | biological_process | choline metabolic process |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0043083 | cellular_component | synaptic cleft |
| A | 0045202 | cellular_component | synapse |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| A | 0090729 | molecular_function | toxin activity |
| B | 0001507 | biological_process | acetylcholine catabolic process in synaptic cleft |
| B | 0003990 | molecular_function | acetylcholinesterase activity |
| B | 0004104 | molecular_function | cholinesterase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006581 | biological_process | acetylcholine catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019695 | biological_process | choline metabolic process |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0043083 | cellular_component | synaptic cleft |
| B | 0045202 | cellular_component | synapse |
| B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PROSITE/UniProt
| site_id | PS00122 |
| Number of Residues | 16 |
| Details | CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGnpraVtVfGeSAG |
| Chain | Residue | Details |
| A | PHE187-GLY202 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| C | TYR191-HIS197 |
| site_id | PS00941 |
| Number of Residues | 11 |
| Details | CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIWvP |
| Chain | Residue | Details |
| A | GLU92-PRO102 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10039","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"25411244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4QWW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
