4QRH
Molecular mechanism and evolution of guanylate kinase regulation by (p)ppGpp
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004385 | molecular_function | GMP kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006163 | biological_process | purine nucleotide metabolic process |
| A | 0009179 | biological_process | purine ribonucleoside diphosphate metabolic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046037 | biological_process | GMP metabolic process |
| A | 0046710 | biological_process | GDP metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004385 | molecular_function | GMP kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006163 | biological_process | purine nucleotide metabolic process |
| B | 0009179 | biological_process | purine ribonucleoside diphosphate metabolic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046037 | biological_process | GMP metabolic process |
| B | 0046710 | biological_process | GDP metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004385 | molecular_function | GMP kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006163 | biological_process | purine nucleotide metabolic process |
| C | 0009179 | biological_process | purine ribonucleoside diphosphate metabolic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0046037 | biological_process | GMP metabolic process |
| C | 0046710 | biological_process | GDP metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004385 | molecular_function | GMP kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006163 | biological_process | purine nucleotide metabolic process |
| D | 0009179 | biological_process | purine ribonucleoside diphosphate metabolic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0046037 | biological_process | GMP metabolic process |
| D | 0046710 | biological_process | GDP metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | GLY16 |
| A | VAL17 |
| A | GLY18 |
| A | LYS19 |
| A | GLY20 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 301 |
| Chain | Residue |
| B | TYR78 |
| B | 0O2303 |
| B | HOH558 |
| B | HOH559 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K B 302 |
| Chain | Residue |
| B | TYR36 |
| B | SER39 |
| B | GLU103 |
| B | 0O2303 |
| B | HOH410 |
| B | HOH411 |
| B | HOH412 |
| site_id | AC4 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE 0O2 B 303 |
| Chain | Residue |
| B | SER15 |
| B | GLY16 |
| B | VAL17 |
| B | GLY18 |
| B | LYS19 |
| B | GLY20 |
| B | SER39 |
| B | ARG43 |
| B | ARG46 |
| B | TYR55 |
| B | GLU74 |
| B | ALA76 |
| B | TYR78 |
| B | TYR83 |
| B | GLY84 |
| B | THR85 |
| B | GLU103 |
| B | ILE104 |
| B | GLU105 |
| B | GLY108 |
| B | MG301 |
| B | K302 |
| B | HOH406 |
| B | HOH445 |
| B | HOH506 |
| B | HOH525 |
| B | HOH526 |
| B | HOH558 |
| B | HOH559 |
| B | HOH560 |
| B | HOH561 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG C 301 |
| Chain | Residue |
| C | 0O2304 |
| C | HOH542 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 302 |
| Chain | Residue |
| C | TYR36 |
| C | SER39 |
| C | GLU103 |
| C | 0O2304 |
| C | HOH422 |
| C | HOH423 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 303 |
| Chain | Residue |
| C | ARG43 |
| C | GLN44 |
| C | ASN81 |
| C | HOH432 |
| C | HOH509 |
| site_id | AC8 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE 0O2 C 304 |
| Chain | Residue |
| C | SER15 |
| C | GLY16 |
| C | VAL17 |
| C | GLY18 |
| C | LYS19 |
| C | GLY20 |
| C | SER39 |
| C | ARG43 |
| C | ARG46 |
| C | TYR55 |
| C | GLU74 |
| C | TYR78 |
| C | TYR83 |
| C | GLY84 |
| C | THR85 |
| C | GLU103 |
| C | ILE104 |
| C | GLU105 |
| C | GLY108 |
| C | MG301 |
| C | K302 |
| C | HOH443 |
| C | HOH481 |
| C | HOH503 |
| C | HOH541 |
| C | HOH542 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG D 301 |
| Chain | Residue |
| D | 0O2306 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K D 302 |
| Chain | Residue |
| D | TYR36 |
| D | SER39 |
| D | GLU103 |
| D | 0O2306 |
| D | HOH419 |
| D | HOH424 |
| D | HOH429 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO D 303 |
| Chain | Residue |
| D | HOH440 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 304 |
| Chain | Residue |
| D | HOH423 |
| D | ALA109 |
| D | LYS110 |
| D | ARG113 |
| D | LEU163 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 305 |
| Chain | Residue |
| D | GLN44 |
| D | ASN81 |
| D | HOH407 |
| D | HOH412 |
| site_id | BC5 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE 0O2 D 306 |
| Chain | Residue |
| D | SER15 |
| D | GLY16 |
| D | VAL17 |
| D | GLY18 |
| D | LYS19 |
| D | GLY20 |
| D | SER39 |
| D | ARG43 |
| D | ARG46 |
| D | TYR55 |
| D | GLU74 |
| D | TYR78 |
| D | TYR83 |
| D | GLY84 |
| D | THR85 |
| D | GLU103 |
| D | ILE104 |
| D | GLU105 |
| D | GLY108 |
| D | MG301 |
| D | K302 |
| D | HOH434 |
| D | HOH497 |
| D | HOH502 |
| D | HOH506 |
| D | HOH519 |
Functional Information from PROSITE/UniProt
| site_id | PS00856 |
| Number of Residues | 18 |
| Details | GUANYLATE_KINASE_1 Guanylate kinase-like signature. TTRqmRegEvdGvdYfFK |
| Chain | Residue | Details |
| A | THR41-LYS58 |
