4QN9
Structure of human NAPE-PLD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0001523 | biological_process | retinoid metabolic process |
| A | 0001659 | biological_process | temperature homeostasis |
| A | 0005634 | cellular_component | nucleus |
| A | 0005635 | cellular_component | nuclear envelope |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0005769 | cellular_component | early endosome |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009395 | biological_process | phospholipid catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0042622 | cellular_component | photoreceptor outer segment membrane |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043227 | cellular_component | membrane-bounded organelle |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048874 | biological_process | host-mediated regulation of intestinal microbiota composition |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070290 | molecular_function | N-acylphosphatidylethanolamine-specific phospholipase D activity |
| A | 0070291 | biological_process | N-acylethanolamine metabolic process |
| A | 0070292 | biological_process | N-acylphosphatidylethanolamine metabolic process |
| A | 0090336 | biological_process | positive regulation of brown fat cell differentiation |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0001523 | biological_process | retinoid metabolic process |
| B | 0001659 | biological_process | temperature homeostasis |
| B | 0005634 | cellular_component | nucleus |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005768 | cellular_component | endosome |
| B | 0005769 | cellular_component | early endosome |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009395 | biological_process | phospholipid catabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0032052 | molecular_function | bile acid binding |
| B | 0042622 | cellular_component | photoreceptor outer segment membrane |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043227 | cellular_component | membrane-bounded organelle |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048874 | biological_process | host-mediated regulation of intestinal microbiota composition |
| B | 0050729 | biological_process | positive regulation of inflammatory response |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070290 | molecular_function | N-acylphosphatidylethanolamine-specific phospholipase D activity |
| B | 0070291 | biological_process | N-acylethanolamine metabolic process |
| B | 0070292 | biological_process | N-acylphosphatidylethanolamine metabolic process |
| B | 0090336 | biological_process | positive regulation of brown fat cell differentiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | HIS185 |
| A | HIS187 |
| A | HIS253 |
| A | ASP284 |
| A | ZN502 |
| A | 3PE503 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 502 |
| Chain | Residue |
| A | HIS343 |
| A | ZN501 |
| A | 3PE503 |
| A | ASP189 |
| A | HIS190 |
| A | ASP284 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 3PE A 503 |
| Chain | Residue |
| A | ALA154 |
| A | PRO156 |
| A | HIS187 |
| A | TYR188 |
| A | ASP189 |
| A | HIS253 |
| A | TRP254 |
| A | LYS256 |
| A | ARG257 |
| A | ASP284 |
| A | MET317 |
| A | GLN320 |
| A | HIS321 |
| A | HIS343 |
| A | ZN501 |
| A | ZN502 |
| A | DXC507 |
| B | 3PE606 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DXC A 504 |
| Chain | Residue |
| A | TYR193 |
| A | TRP218 |
| A | LYS221 |
| A | CYS222 |
| B | TYR159 |
| B | MET160 |
| B | DXC602 |
| B | DXC607 |
| B | DXC610 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DXC A 505 |
| Chain | Residue |
| A | TYR159 |
| A | MET160 |
| A | DXC506 |
| A | HOH623 |
| B | TYR193 |
| B | TRP218 |
| B | LYS221 |
| B | CYS222 |
| B | HOH701 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DXC A 506 |
| Chain | Residue |
| A | DXC505 |
| B | MET260 |
| B | DXC603 |
| B | DXC603 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DXC A 507 |
| Chain | Residue |
| A | THR258 |
| A | THR258 |
| A | LEU259 |
| A | 3PE503 |
| B | DXC602 |
| B | DXC602 |
| B | DXC607 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 508 |
| Chain | Residue |
| A | ARG166 |
| A | ARG167 |
| B | SER173 |
| B | HOH736 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 509 |
| Chain | Residue |
| A | SER152 |
| A | HOH617 |
| B | SER151 |
| B | SER152 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DXC B 601 |
| Chain | Residue |
| A | TYR159 |
| A | HOH614 |
| B | TYR188 |
| B | TRP218 |
| B | ARG257 |
| B | DXC603 |
| B | DXC603 |
| B | HOH740 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DXC B 602 |
| Chain | Residue |
| A | MET260 |
| A | DXC504 |
| A | DXC507 |
| A | DXC507 |
| B | HOH743 |
| B | HOH748 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE DXC B 603 |
| Chain | Residue |
| A | DXC506 |
| A | DXC506 |
| B | THR258 |
| B | THR258 |
| B | LEU259 |
| B | LEU259 |
| B | DXC601 |
| B | DXC601 |
| B | 3PE606 |
| B | 3PE606 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 604 |
| Chain | Residue |
| B | HIS185 |
| B | HIS187 |
| B | HIS253 |
| B | ASP284 |
| B | ZN605 |
| B | 3PE606 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 605 |
| Chain | Residue |
| B | ASP284 |
| B | HIS343 |
| B | ZN604 |
| B | 3PE606 |
| B | ASP189 |
| B | HIS190 |
| site_id | BC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 3PE B 606 |
| Chain | Residue |
| A | 3PE503 |
| B | ALA154 |
| B | PRO156 |
| B | HIS187 |
| B | TYR188 |
| B | ASP189 |
| B | HIS253 |
| B | TRP254 |
| B | LYS256 |
| B | ARG257 |
| B | ASP284 |
| B | MET317 |
| B | GLN320 |
| B | HIS321 |
| B | HIS343 |
| B | DXC603 |
| B | DXC603 |
| B | ZN604 |
| B | ZN605 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DXC B 607 |
| Chain | Residue |
| A | TYR188 |
| A | TRP218 |
| A | ARG257 |
| A | DXC504 |
| A | DXC507 |
| B | TYR159 |
| B | HOH721 |
| B | HOH740 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DXC B 608 |
| Chain | Residue |
| A | LEU259 |
| B | LYS256 |
| B | LEU259 |
| B | MET260 |
| B | DXC609 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DXC B 609 |
| Chain | Residue |
| A | LYS256 |
| A | LEU259 |
| A | MET260 |
| B | LEU259 |
| B | DXC608 |
| B | DXC610 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DXC B 610 |
| Chain | Residue |
| A | DXC504 |
| B | GLY161 |
| B | PRO162 |
| B | ALA348 |
| B | DXC609 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 611 |
| Chain | Residue |
| A | THR171 |
| A | SER173 |
| A | HOH611 |
| B | ARG166 |
| B | ARG167 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25684574 |
| Chain | Residue | Details |
| A | HIS185 | |
| B | ASP189 | |
| B | HIS190 | |
| B | HIS253 | |
| B | ASP284 | |
| B | HIS343 | |
| A | HIS187 | |
| A | ASP189 | |
| A | HIS190 | |
| A | HIS253 | |
| A | ASP284 | |
| A | HIS343 | |
| B | HIS185 | |
| B | HIS187 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:25684574 |
| Chain | Residue | Details |
| A | TYR188 | |
| A | HIS321 | |
| B | TYR188 | |
| B | HIS321 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25684574, ECO:0007744|PDB:4QN9 |
| Chain | Residue | Details |
| A | LYS256 | |
| A | MET260 | |
| A | ALA348 | |
| B | LYS256 | |
| B | MET260 | |
| B | ALA348 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 |
