4QKF

Crystal structure of human ALKBH7 in complex with N-oxalylglycine and Mn(II)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006631	biological_process	fatty acid metabolic process
A	0006974	biological_process	DNA damage response
A	0010883	biological_process	regulation of lipid storage
A	0012501	biological_process	programmed cell death
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0035513	biological_process	oxidative RNA demethylation
A	0035515	molecular_function	oxidative RNA demethylase activity
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	1902445	biological_process	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
A	1990984	molecular_function	tRNA demethylase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006631	biological_process	fatty acid metabolic process
B	0006974	biological_process	DNA damage response
B	0010883	biological_process	regulation of lipid storage
B	0012501	biological_process	programmed cell death
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0035513	biological_process	oxidative RNA demethylation
B	0035515	molecular_function	oxidative RNA demethylase activity
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	1902445	biological_process	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
B	1990984	molecular_function	tRNA demethylase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006631	biological_process	fatty acid metabolic process
C	0006974	biological_process	DNA damage response
C	0010883	biological_process	regulation of lipid storage
C	0012501	biological_process	programmed cell death
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0035513	biological_process	oxidative RNA demethylation
C	0035515	molecular_function	oxidative RNA demethylase activity
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	1902445	biological_process	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
C	1990984	molecular_function	tRNA demethylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 300

Chain	Residue
A	HIS121
A	ASP123
A	HIS177
A	OGA301

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE OGA A 301

Chain	Residue
A	ARG197
A	SER199
A	ARG203
A	MN300
A	HOH430
A	HIS108
A	HIS121
A	TYR165
A	HIS177
A	ILE179

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN B 300

Chain	Residue
A	HOH449
B	HIS121
B	ASP123
B	HIS177
B	HOH426

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN C 301

Chain	Residue
C	HIS121
C	ASP123
C	HIS177
C	OGA302

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE OGA C 302

Chain	Residue
C	ILE70
C	LEU110
C	ILE118
C	HIS121
C	ASP123
C	TYR165
C	HIS177
C	ARG197
C	SER199
C	ILE201
C	ARG203
C	MN301
C	HOH457

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN C 303

Chain	Residue
A	GLU189
B	GLU189
C	GLU189

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25122757","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25122757","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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