Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4QH5

The GLIC pentameric Ligand-Gated Ion Channel (wild-type) crystallized in phosphate buffer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006813	biological_process	potassium ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT A 401

Chain	Residue
C	LMT402
D	HOH515

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT A 402

Chain	Residue
A	ILE240

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 403

Chain	Residue
A	PRO74
A	ARG77

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT B 401

Chain	Residue
A	ALA237
B	ALA237

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 402

Chain	Residue
B	ARG85

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA B 403

Chain	Residue
B	ILE71
B	PRO68

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE LMT C 402

Chain	Residue
A	LMT401
C	ILE240

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 403

Chain	Residue
C	PRO74
C	ILE76
C	ARG85

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA C 404

Chain	Residue
C	PRO68
C	ILE71

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PLC C 405

Chain	Residue
C	ARG118
C	PHE121
C	TYR194
C	TYR254
C	ASN307
C	PHE315

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE LMT D 401

Chain	Residue
D	ALA237
D	ILE240
E	THR244

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA D 402

Chain	Residue
D	PRO68
D	ILE71
D	TRP72
D	ILE73

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 403

Chain	Residue
D	ARG77

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 402

Chain	Residue
E	PRO74
E	ARG77

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PLC E 403

Chain	Residue
E	ARG118
E	PHE121
E	TYR194
E	TYR254
E	ASN307
E	PHE315

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)