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4QGE

phosphodiesterase-9A in complex with inhibitor WYQ-C36D

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
A0004117molecular_functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
A0010613biological_processpositive regulation of cardiac muscle hypertrophy
A0016787molecular_functionhydrolase activity
A0019933biological_processcAMP-mediated signaling
A0032587cellular_componentruffle membrane
A0042383cellular_componentsarcolemma
A0042995cellular_componentcell projection
A0046068biological_processcGMP metabolic process
A0046069biological_processcGMP catabolic process
A0046872molecular_functionmetal ion binding
A0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
A0048101molecular_functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
A0048471cellular_componentperinuclear region of cytoplasm
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
B0004117molecular_functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
B0010613biological_processpositive regulation of cardiac muscle hypertrophy
B0016787molecular_functionhydrolase activity
B0019933biological_processcAMP-mediated signaling
B0032587cellular_componentruffle membrane
B0042383cellular_componentsarcolemma
B0042995cellular_componentcell projection
B0046068biological_processcGMP metabolic process
B0046069biological_processcGMP catabolic process
B0046872molecular_functionmetal ion binding
B0047555molecular_function3',5'-cyclic-GMP phosphodiesterase activity
B0048101molecular_functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
B0048471cellular_componentperinuclear region of cytoplasm
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 35O A 601
ChainResidue
AMET365
ALEU420
ATYR424
AALA452
AGLN453
APHE456
AHOH709
AHOH721
AHOH745

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN A 602
ChainResidue
AHIS256
AHIS292
AASP293
AASP402
AHOH701
AHOH702

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 603
ChainResidue
AASP293
AHOH702
AHOH703
AHOH704
AHOH705
AHOH706

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 35O B 601
ChainResidue
AMET500
ALEU503
BMET365
BLEU420
BTYR424
BPHE441
BALA452
BGLN453
BPHE456
BHOH716
BHOH729
BHOH739
BHOH765

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN B 602
ChainResidue
BHIS256
BHIS292
BASP293
BASP402
BHOH701
BHOH702

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 603
ChainResidue
BASP293
BHOH701
BHOH703
BHOH704
BHOH705
BHOH706

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGynNtY
ChainResidueDetails
AHIS292-TYR303

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
AALA312
BALA312

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
AALA312
ATRP484
ASER512
BALA312
BTRP484
BSER512

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:25432025, ECO:0007744|PDB:4QGE
ChainResidueDetails
AASN316
AILE352
AARG353
AILE462
BASN316
BILE352
BARG353
BILE462

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8QZV1
ChainResidueDetails
AMET379
BMET379

227344

PDB entries from 2024-11-13

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