4QGE
phosphodiesterase-9A in complex with inhibitor WYQ-C36D
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0004115 | molecular_function | 3',5'-cyclic-AMP phosphodiesterase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0010613 | biological_process | positive regulation of cardiac muscle hypertrophy |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019933 | biological_process | cAMP-mediated signaling |
| A | 0032587 | cellular_component | ruffle membrane |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042995 | cellular_component | cell projection |
| A | 0046068 | biological_process | cGMP metabolic process |
| A | 0046069 | biological_process | cGMP catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047555 | molecular_function | 3',5'-cyclic-GMP phosphodiesterase activity |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0004115 | molecular_function | 3',5'-cyclic-AMP phosphodiesterase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0010613 | biological_process | positive regulation of cardiac muscle hypertrophy |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019933 | biological_process | cAMP-mediated signaling |
| B | 0032587 | cellular_component | ruffle membrane |
| B | 0042383 | cellular_component | sarcolemma |
| B | 0042995 | cellular_component | cell projection |
| B | 0046068 | biological_process | cGMP metabolic process |
| B | 0046069 | biological_process | cGMP catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047555 | molecular_function | 3',5'-cyclic-GMP phosphodiesterase activity |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 35O A 601 |
| Chain | Residue |
| A | MET365 |
| A | LEU420 |
| A | TYR424 |
| A | ALA452 |
| A | GLN453 |
| A | PHE456 |
| A | HOH709 |
| A | HOH721 |
| A | HOH745 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 602 |
| Chain | Residue |
| A | HIS256 |
| A | HIS292 |
| A | ASP293 |
| A | ASP402 |
| A | HOH701 |
| A | HOH702 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 603 |
| Chain | Residue |
| A | ASP293 |
| A | HOH702 |
| A | HOH703 |
| A | HOH704 |
| A | HOH705 |
| A | HOH706 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 35O B 601 |
| Chain | Residue |
| A | MET500 |
| A | LEU503 |
| B | MET365 |
| B | LEU420 |
| B | TYR424 |
| B | PHE441 |
| B | ALA452 |
| B | GLN453 |
| B | PHE456 |
| B | HOH716 |
| B | HOH729 |
| B | HOH739 |
| B | HOH765 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 602 |
| Chain | Residue |
| B | HIS256 |
| B | HIS292 |
| B | ASP293 |
| B | ASP402 |
| B | HOH701 |
| B | HOH702 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 603 |
| Chain | Residue |
| B | ASP293 |
| B | HOH701 |
| B | HOH703 |
| B | HOH704 |
| B | HOH705 |
| B | HOH706 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGynNtY |
| Chain | Residue | Details |
| A | HIS292-TYR303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083 |
| Chain | Residue | Details |
| A | ALA312 | |
| B | ALA312 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O76083 |
| Chain | Residue | Details |
| A | ALA312 | |
| A | TRP484 | |
| A | SER512 | |
| B | ALA312 | |
| B | TRP484 | |
| B | SER512 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25432025, ECO:0007744|PDB:4QGE |
| Chain | Residue | Details |
| A | ASN316 | |
| A | ILE352 | |
| A | ARG353 | |
| A | ILE462 | |
| B | ASN316 | |
| B | ILE352 | |
| B | ARG353 | |
| B | ILE462 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8QZV1 |
| Chain | Residue | Details |
| A | MET379 | |
| B | MET379 |
