4QBQ

Crystal structure of DNMT3a ADD domain bound to H3 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006306	biological_process	DNA methylation
A	0010468	biological_process	regulation of gene expression
C	0006306	biological_process	DNA methylation
C	0010468	biological_process	regulation of gene expression

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 701

Chain	Residue
A	CYS549
A	CYS554
A	CYS583
A	CYS586

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 702

Chain	Residue
A	CYS537
A	CYS540
A	CYS559
A	CYS562

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 703

Chain	Residue
A	CYS497
A	CYS514
A	CYS517
A	CYS494

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 701

Chain	Residue
C	CYS549
C	CYS554
C	CYS583
C	CYS586

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 702

Chain	Residue
C	CYS537
C	CYS540
C	CYS559
C	CYS562

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 703

Chain	Residue
C	CYS494
C	CYS497
C	CYS514
C	CYS517

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635

Chain	Residue	Details
P	ARG2
C	ILE493-GLU523

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088

Chain	Residue	Details
P	THR3
C	GLN534-GLY590

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
P	LYS4

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594

Chain	Residue	Details
P	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790

Chain	Residue	Details
P	THR6

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433

Chain	Residue	Details
P	ARG8

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